Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Joline S.J. Lim"'
Autor:
Robert John Walsh, Rebecca Ong, Seng Wee Cheo, Peter Q.J. Low, Aishwarya Jayagopal, Matilda Lee, Natalie Ngoi, Samuel G. Ow, Andrea L.A. Wong, Siew Eng Lim, Yi Wan Lim, Valerie Heong, Raghav Sundar, Ross A. Soo, Cheng Ean Chee, Wei Peng Yong, Boon Cher Goh, Soo Chin Lee, David S.P. Tan, Joline S.J. Lim
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionMolecular profiling of metastatic breast cancer (MBC) through the widespread use of next-generation sequencing (NGS) has highlighted actionable mutations and driven trials of targeted therapy matched to tumour molecular profiles, with imp
Externí odkaz:
https://doaj.org/article/98dbdbab3f7349b688320adc069900de
Autor:
Johann S. de Bono, Yvette Drew, Juanita S. Lopez, Bristi Basu, Ruth Plummer, Udai Banerji, Christopher J. Lord, Andrew Foxley, Justin P.O. Lindemann, Paul Rugman, Emma Hall, Laura Finneran, Karen E. Swales, Shaun Decordova, Florence I. Raynaud, Ruth Ruddle, Nicholas C. Turner, Heidrun Gevensleben, Neha Chopra, Nina Tunariu, Alison Turner, Mona Parmar, Ruth Matthews, Sarah Ward, Daniel Nava Rodrigues, Ines Figueiredo, Susana Miranda, Ruth Riisnaes, Rowan Miller, Desamparados Roda, Suzanne Carreira, Joline S.J. Lim, Stephen J. Pettitt, Vasiliki Michalarea, Rebecca Kristeleit, Timothy A. Yap
Preclinical studies have demonstrated synergy between PARP and PI3K/AKT pathway inhibitors in BRCA1 and BRCA2 (BRCA1/2)–deficient and BRCA1/2-proficient tumors. We conducted an investigator-initiated phase I trial utilizing a prospective intrapatie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01e33adbfd1faf3496d00cefbd4e1d17
https://doi.org/10.1158/2159-8290.c.6547955.v1
https://doi.org/10.1158/2159-8290.c.6547955.v1
Autor:
Johann S. de Bono, Yvette Drew, Juanita S. Lopez, Bristi Basu, Ruth Plummer, Udai Banerji, Christopher J. Lord, Andrew Foxley, Justin P.O. Lindemann, Paul Rugman, Emma Hall, Laura Finneran, Karen E. Swales, Shaun Decordova, Florence I. Raynaud, Ruth Ruddle, Nicholas C. Turner, Heidrun Gevensleben, Neha Chopra, Nina Tunariu, Alison Turner, Mona Parmar, Ruth Matthews, Sarah Ward, Daniel Nava Rodrigues, Ines Figueiredo, Susana Miranda, Ruth Riisnaes, Rowan Miller, Desamparados Roda, Suzanne Carreira, Joline S.J. Lim, Stephen J. Pettitt, Vasiliki Michalarea, Rebecca Kristeleit, Timothy A. Yap
Supplementary Tables 1-7; Supplementary Figures 1-2; Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b42dc1c2ce5b8015019651ef216b42
https://doi.org/10.1158/2159-8290.22535825
https://doi.org/10.1158/2159-8290.22535825
Autor:
Nicholas C. Turner, Juanita S. Lopez, Timothy A. Yap, Emma Hall, Alison Turner, Florence I. Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Laura Finneran, Toby Prout, Mona Parmar, Jenny King, Margaret Hills, Michael Hubank, Paula Z. Proszek, Heidrun Gevensleben, Sarah Hrebien, Alex Pearson, Isaac Garcia-Murillas, Maria Teresa Herrera-Abreu, Rosalind J. Cutts, Alicia F.C. Okines, Alistair Ring, Anne C. Armstrong, Iain R. Macpherson, Joline S.J. Lim, Javier Pascual
Baseline tissue biomarker analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b64d725e62326fa4fbc9ae6bd1b3db
https://doi.org/10.1158/2159-8290.22535447
https://doi.org/10.1158/2159-8290.22535447
Autor:
Nicholas C. Turner, Juanita S. Lopez, Timothy A. Yap, Emma Hall, Alison Turner, Florence I. Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Laura Finneran, Toby Prout, Mona Parmar, Jenny King, Margaret Hills, Michael Hubank, Paula Z. Proszek, Heidrun Gevensleben, Sarah Hrebien, Alex Pearson, Isaac Garcia-Murillas, Maria Teresa Herrera-Abreu, Rosalind J. Cutts, Alicia F.C. Okines, Alistair Ring, Anne C. Armstrong, Iain R. Macpherson, Joline S.J. Lim, Javier Pascual
RMH200 panel design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463cc86a1d265fa62da6f6887c6a661c
https://doi.org/10.1158/2159-8290.22535438.v1
https://doi.org/10.1158/2159-8290.22535438.v1
Autor:
Nicholas C. Turner, Juanita S. Lopez, Timothy A. Yap, Emma Hall, Alison Turner, Florence I. Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Laura Finneran, Toby Prout, Mona Parmar, Jenny King, Margaret Hills, Michael Hubank, Paula Z. Proszek, Heidrun Gevensleben, Sarah Hrebien, Alex Pearson, Isaac Garcia-Murillas, Maria Teresa Herrera-Abreu, Rosalind J. Cutts, Alicia F.C. Okines, Alistair Ring, Anne C. Armstrong, Iain R. Macpherson, Joline S.J. Lim, Javier Pascual
Cyclin-dependent kinase 4/6 (CDK4/6) and PI3K inhibitors synergize in PIK3CA-mutant ER-positive HER2-negative breast cancer models. We conducted a phase Ib trial investigating the safety and efficacy of doublet CDK4/6 inhibitor palbociclib plus selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2188840c665bdd2ddabfa9e80f44d33
https://doi.org/10.1158/2159-8290.c.6547859.v1
https://doi.org/10.1158/2159-8290.c.6547859.v1
Autor:
Dario Campana, Boon Cher Goh, Priscillia J.X. Koe, Jedidah L.M. Lieow, Nesaretnam Barr Kumarakulasinghe, Wan Qin Chong, Hon Lyn Tan, Raghav Sundar, Elaine Coustan-Smith, Mabel Z.Q. Foo, Yoon Sim Yap, Lavina Bharwani, Samuel G.W. Ow, Sing Huang Tan, Michelle L.M. Poon, Liang Piu Koh, Lip Kun Tan, Wei Peng Yong, Kritika Yadav, Andrea Wong, Joline S.J. Lim, Noriko Shimasaki, Soo-Chin Lee
Purpose:Natural killer (NK) cells exert antibody-dependent cell cytotoxicity (ADCC). We infused expanded, activated autologous NK cells to potentiate trastuzumab-mediated ADCC in patients with HER2-positive malignancies.Patients and Methods:In a phas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaab96d906f2da5fd2a148efdea4c8ed
https://doi.org/10.1158/1078-0432.c.6529842
https://doi.org/10.1158/1078-0432.c.6529842
Autor:
Soo-Chin Lee, Boon Cher Goh, Bee Choo Tai, Lingzhi Wang, Supriya Jain, Kritika Yadav, Raghav Sundar, Cheng Ean Chee, David S.P. Tan, Ross A. Soo, Wei Peng Yong, Hon Lyn Tan, Joan R.E. Choo, Matilda Lee, Yi Wan Lim, Siew Eng Lim, Wan Qin Chong, Yvonne L.E. Ang, Gloria H.J. Chan, Natalie Y.L. Ngoi, Samuel G.W. Ow, Andrea L.A. Wong, Joline S.J. Lim
Purpose:RET is an estrogen response gene with preclinical studies demonstrating cross-talk between the RET and estrogen receptor (ER) pathways. We investigate the role of lenvatinib, a multikinase inhibitor with potent activity against RET, in patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e493f677e970d70092bf8afa81bf17c
https://doi.org/10.1158/1078-0432.c.6532424.v1
https://doi.org/10.1158/1078-0432.c.6532424.v1
Autor:
Soo-Chin Lee, Boon Cher Goh, Bee Choo Tai, Lingzhi Wang, Supriya Jain, Kritika Yadav, Raghav Sundar, Cheng Ean Chee, David S.P. Tan, Ross A. Soo, Wei Peng Yong, Hon Lyn Tan, Joan R.E. Choo, Matilda Lee, Yi Wan Lim, Siew Eng Lim, Wan Qin Chong, Yvonne L.E. Ang, Gloria H.J. Chan, Natalie Y.L. Ngoi, Samuel G.W. Ow, Andrea L.A. Wong, Joline S.J. Lim
Supplementary Table from Phase Ib/II Dose Expansion Study of Lenvatinib Combined with Letrozole in Postmenopausal Women with Hormone Receptor–Positive Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02061fae97a0b8e77fb74d487409f1d
https://doi.org/10.1158/1078-0432.22486937
https://doi.org/10.1158/1078-0432.22486937
Autor:
Soo-Chin Lee, Boon Cher Goh, Bee Choo Tai, Lingzhi Wang, Supriya Jain, Kritika Yadav, Raghav Sundar, Cheng Ean Chee, David S.P. Tan, Ross A. Soo, Wei Peng Yong, Hon Lyn Tan, Joan R.E. Choo, Matilda Lee, Yi Wan Lim, Siew Eng Lim, Wan Qin Chong, Yvonne L.E. Ang, Gloria H.J. Chan, Natalie Y.L. Ngoi, Samuel G.W. Ow, Andrea L.A. Wong, Joline S.J. Lim
Supplementary Data from Phase Ib/II Dose Expansion Study of Lenvatinib Combined with Letrozole in Postmenopausal Women with Hormone Receptor–Positive Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00fc277da44ab4288b38054c7a7e0c6
https://doi.org/10.1158/1078-0432.22486946
https://doi.org/10.1158/1078-0432.22486946