Výsledky vyhledávání - "Jolien Janssens"

Synthesis, modeling and evaluation of 3′-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3′-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors

Autor: Anna Karlsson, Andrea Negri, Nicola Solaroli, Jan Balzarini, Federico Gago, Sara Van Poecke, Serge Van Calenbergh, Jolien Janssens

Publikováno v: Org. Biomol. Chem.. 9:892-901

Based on the presumed binding mode of an earlier identified inhibitor, we herein report new 3'-modified nucleosides as potent and selective inhibitors of mitochondrial thymidine kinase (TK2). A series of thirteen 3'-amino-, 3'-guanidino- and 3'-tetra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d7e532139c51bf86f8ba8c5150f1ff
https://doi.org/10.1039/c0ob00591f

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