Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jolet Y. Mimpen"'
Autor:
Jolet Y. Mimpen, Robert Hedley, Anna Ridley, Mathew J. Baldwin, Dylan Windell, Ananya Bhalla, Lorenzo Ramos-Mucci, Christopher D. Buckley, Mark C. Coles, Abtin Alvand, Andrew J. Price, Andrew J. Carr, Stephanie G. Dakin, Sarah J. B. Snelling
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Objectives Osteoarthritis (OA) is increasingly recognised as a whole joint disease, with an important role for synovium. However, the repertoire of immune cells and fibroblasts that constitute OA synovium remains understudied. This study aim
Externí odkaz:
https://doaj.org/article/ad4812c86da64d16ae2f61590a6143f6
Autor:
Mathew J. Baldwin, Jolet Y. Mimpen, Adam P. Cribbs, Edward Stace, Martin Philpott, Stephanie G. Dakin, Andrew J. Carr, Sarah JB. Snelling
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2022)
Biomaterial augmentation of surgically repaired rotator cuff tendon tears aims to improve the high failure rates (∼40%) of traditional repairs. Biomaterials that can alter cellular phenotypes through the provision of microscale topographical cues a
Externí odkaz:
https://doaj.org/article/92586ca94d5f405885ec2e564c6fe06d
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Interleukin (IL)-17A, a pro-inflammatory cytokine that is linked to the pathology of several inflammatory diseases, has been shown to be upregulated in early human tendinopathy and to mediate inflammatory and tissue remodelling events. However, it re
Externí odkaz:
https://doaj.org/article/5cfee772202441d8bc7b815beaf17b6f
Autor:
Jolet Y. Mimpen, Mathew J. Baldwin, Adam P. Cribbs, Martin Philpott, Andrew J. Carr, Stephanie G. Dakin, Sarah J.B. Snelling
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Increased interleukin (IL)-17A has been identified in joints affected by osteoarthritis (OA), but it is unclear how IL-17A, and its family members IL-17AF and IL-17F, can contribute to human OA pathophysiology. Therefore, we aimed to evaluate the gen
Externí odkaz:
https://doaj.org/article/345ffedc78294f3590eb2940f1245794
Publikováno v:
Rheumatology. 62
Background/Aims Traditionally viewed from the perspective of cartilage degeneration, osteoarthritis is increasingly seen as a disease of global joint dysfunction. Connective tissue extracellular matrix (ECM) is a crucial determinant of joint mechanob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58186ac478d8fca4e63298fa6e9061b0
https://doi.org/10.1093/rheumatology/kead104.117
https://doi.org/10.1093/rheumatology/kead104.117
Autor:
Jolet Y. Mimpen, Lorenzo Ramos-Mucci, Claudia Paul, Alina Kurjan, Phillipa Hulley, Chinemerem Ikwuanusi, Steve Gwilym, Mathew J. Baldwin, Adam P. Cribbs, Sarah J.B. Snelling
The molecular and cellular basis of health in human tendons remains poorly understood. Amongst human tendons, the hamstrings are the least likely to be injured or degenerate, providing a prototypic healthy tendon reference. The aim of this study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f6bd286404d6fd9ce856be42c45258
https://doi.org/10.1101/2022.12.19.521110
https://doi.org/10.1101/2022.12.19.521110
Autor:
Andrey Nezhentsev, Roxanna E Abhari, Mathew J Baldwin, Jolet Y Mimpen, Edyta Augustyniak, Mark Isaacs, Pierre-Alexis Mouthuy, Andrew J Carr, Sarah J. B Snelling
Publikováno v:
Rheumatology. 61
Background/Aims Recurrent tears after surgical tendon repair remain common, with 40% of rotator cuff repairs failing within one year. Repair failures can be partly attributed to the use of sutures not designed for the tendon cellular niche nor design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c2022071c473ffc44b1162cfb77d5b
https://doi.org/10.1093/rheumatology/keac133.280
https://doi.org/10.1093/rheumatology/keac133.280
Previously, we described a robust protocol for the isolation of nuclei from snap frozen fibrous tissues, including tendon and ligament, for use in single nucleus RNA Sequencing. This use of snap-frozen tissue enables tissues that are collected from d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3856427334e8dc7c11f50fd032fc4940
https://doi.org/10.17504/protocols.io.rm7vzyx75lx1/v1
https://doi.org/10.17504/protocols.io.rm7vzyx75lx1/v1
Autor:
Jolet Y Mimpen, Claudia Paul, Lorenzo Ramos-Mucci, Tendon Seed Network, Adam Cribbs, Mathew Baldwin, Sarah Snelling
The collection of (human) tissue is essential for many aspects of biomedical research. In order to maintain tissue quality and achieve reproducible and representative results, it is critical that the tissue is collected in a consistent manner, especi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7feca8cce1ce5c48dc5a7b1b6cd69d1b
https://doi.org/10.17504/protocols.io.b2tqqemw
https://doi.org/10.17504/protocols.io.b2tqqemw
Autor:
Mathew J. Baldwin, Jolet Y. Mimpen, Adam P. Cribbs, Edward Stace, Martin Philpott, Stephanie G. Dakin, Andrew J. Carr, Sarah JB. Snelling
Publikováno v:
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology, Vol 9 (2022)
Frontiers in Bioengineering and Biotechnology, Vol 9 (2022)
Biomaterial augmentation of surgically repaired rotator cuff tendon tears aims to improve the high failure rates (∼40%) of traditional repairs. Biomaterials that can alter cellular phenotypes through the provision of microscale topographical cues a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c74e4a3d52a68afa48fa722fa40ef2
https://pubmed.ncbi.nlm.nih.gov/35096791
https://pubmed.ncbi.nlm.nih.gov/35096791