Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Jolene K. Diedrich"'
Autor:
Swagata Ghatak, Jolene K. Diedrich, Maria Talantova, Nivedita Bhadra, Henry Scott, Meetal Sharma, Matthew Albertolle, Nicholas J. Schork, John R. Yates III, Stuart A. Lipton
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract Standard single‐cell (sc) proteomics of disease states inferred from multicellular organs or organoids cannot currently be related to single‐cell physiology. Here, a scPatch‐Clamp/Proteomics platform is developed on single neurons gene
Externí odkaz:
https://doaj.org/article/7f4dd02cff274168ba32976ec18c4157
Autor:
Javier Guenaga, Mehrdad Alirezaei, Yu Feng, Mohamad-Gabriel Alameh, Wen-Hsin Lee, Sabyasachi Baboo, Jocelyn Cluff, Richard Wilson, Shridhar Bale, Gabriel Ozorowski, Paulo Lin, Ying Tam, Jolene K. Diedrich, John R. Yates, James C. Paulson, Andrew B. Ward, Drew Weissman, Richard T. Wyatt
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The HIV-1 envelope glycoprotein (Env) is the sole neutralizing determinant on the surface of the virus. The Env gp120 and gp41 subunits mediate receptor binding and membrane fusion and are generated from the gp160 precursor by cellular furins. This c
Externí odkaz:
https://doaj.org/article/37d2ab50b881474f81175ff5bf88cc4e
Autor:
Itabajara da Silva Vaz Junior, Stephen Lu, Antônio F. M. Pinto, Jolene K. Diedrich, John R. Yates, Albert Mulenga, Carlos Termignoni, José Marcos Ribeiro, Lucas Tirloni
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-20 (2024)
Abstract Background When feeding on a vertebrate host, ticks secrete saliva, which is a complex mixture of proteins, lipids, and other molecules. Tick saliva assists the vector in modulating host hemostasis, immunity, and tissue repair mechanisms. Wh
Externí odkaz:
https://doaj.org/article/99fc7c4fd72c4b37aa8e57f0649af10f
Autor:
Corina E. Antal, Tae Gyu Oh, Stefan Aigner, En-Ching Luo, Brian A. Yee, Tania Campos, Hervé Tiriac, Katherine L. Rothamel, Zhang Cheng, Henry Jiao, Allen Wang, Nasun Hah, Elizabeth Lenkiewicz, Jan C. Lumibao, Morgan L. Truitt, Gabriela Estepa, Ester Banayo, Senada Bashi, Edgar Esparza, Ruben M. Munoz, Jolene K. Diedrich, Nicole M. Sodir, Jasmine R. Mueller, Cory R. Fraser, Erkut Borazanci, David Propper, Daniel D. Von Hoff, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Haiyong Han, Andrew M. Lowy, Michael T. Barrett, Dannielle D. Engle, Gerard I. Evan, Gene W. Yeo, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here we uncover a druggable SE
Externí odkaz:
https://doaj.org/article/57cc744cc0404cd39ed1bebee4e6eee7
Autor:
Manabu Kawata, Daniel B. McClatchy, Jolene K. Diedrich, Merissa Olmer, Kristen A. Johnson, John R. Yates, Martin K. Lotz
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Osteoarthritis (OA) is the most common joint disorder, and disease-modifying OA drugs (DMOADs) represent a major need in OA management. Krüppel-like factor 4 (KLF4) is a central transcription factor upregulating regenerative and protective functions
Externí odkaz:
https://doaj.org/article/84f445dd7562469d8561ab051947bdb1
Autor:
Tae Kwon Kim, Lucas Tirloni, Emily Bencosme-Cuevas, Tae Heung Kim, Jolene K. Diedrich, John R. Yates, Albert Mulenga
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-25 (2021)
Abstract Background Lyme disease (LD) caused by Borrelia burgdorferi is the most prevalent tick-borne disease. There is evidence that vaccines based on tick proteins that promote tick transmission of B. burgdorferi could prevent LD. As Ixodes scapula
Externí odkaz:
https://doaj.org/article/8fceac292aff4486b0ea95dd25c9fd2b
Autor:
Shan Lu, Qiaozhen Ye, Digvijay Singh, Yong Cao, Jolene K. Diedrich, John R. Yates, Elizabeth Villa, Don W. Cleveland, Kevin D. Corbett
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The SARS-CoV-2 nucleocapsid (N) protein binds the viral RNA genome and contains two ordered domains flanked by three intrinsically-disordered regions. Here, the authors show that RNA binding induces liquid-liquid phase separation of N, which is drive
Externí odkaz:
https://doaj.org/article/3b746ca51c02440b86972614f0f986c1
Autor:
Nam-Kyung Yu, Daniel B. McClatchy, Jolene K. Diedrich, Sarah Romero, Jun-Hyeok Choi, Salvador Martínez-Bartolomé, Claire M. Delahunty, Alysson R. Muotri, John R. Yates, III
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103321- (2021)
Summary: A single protein can be multifaceted depending on the cellular contexts and interacting molecules. LIN28A is an RNA-binding protein that governs developmental timing, cellular proliferation, differentiation, stem cell pluripotency, and metab
Externí odkaz:
https://doaj.org/article/4350b3b7587746e6bd8c1c81b0bf89e6
Autor:
Qian Chu, Thomas F. Martinez, Sammy Weiser Novak, Cynthia J. Donaldson, Dan Tan, Joan M. Vaughan, Tina Chang, Jolene K. Diedrich, Leo Andrade, Andrew Kim, Tong Zhang, Uri Manor, Alan Saghatelian
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Cells trigger an unfolded protein response (UPR) in the endoplasmic reticulum, but its regulation by mitochondria is unclear. Here, the authors report a 54-residue microprotein PIGBOS that participates in inter-organelle contact between the endoplasm
Externí odkaz:
https://doaj.org/article/88ad530f1b6144599a5346421f1a1e1d
Autor:
Jordan E. Burke, Adam D. Longhurst, Prashanthi Natarajan, Beiduo Rao, John Liu, Jade Sales-Lee, Yasaman Mortensen, James J. Moresco, Jolene K. Diedrich, John R. Yates, Hiten D. Madhani
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2235-2244 (2019)
The human pathogenic yeast Cryptococcus neoformans silences transposable elements using endo-siRNAs and an Argonaute, Ago1. Endo-siRNAs production requires the RNA-dependent RNA polymerase, Rdp1, and two partially redundant Dicer enzymes, Dcr1 and Dc
Externí odkaz:
https://doaj.org/article/7f7f371b930043a1aae902382619436c