Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jolene Caifeng Ho"'
Autor:
Shojiro Kitajima, Wendi Sun, Kian Leong Lee, Jolene Caifeng Ho, Seiichi Oyadomari, Takashi Okamoto, Hisao Masai, Lorenz Poellinger, Hiroyuki Kato
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract UTX/KDM6A encodes a major histone H3 lysine 27 (H3K27) demethylase, and is frequently mutated in various types of human cancers. Although UTX appears to play a crucial role in oncogenesis, the mechanisms involved are still largely unknown. H
Externí odkaz:
https://doaj.org/article/269f3fc324ab4ebb93a68e6e694339e8
Autor:
Yanli Liu, Su Qin, Tsai-Yu Chen, Ming Lei, Shilpa S. Dhar, Jolene Caifeng Ho, Aiping Dong, Peter Loppnau, Yanjun Li, Min Gyu Lee, Jinrong Min
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
MLL3 and MLL4 are members of the SET1/MLL family of histone H3K4 methyltransferases, which are responsible for monomethylating histone H3K4 on enhancers. Here the authors show that an extended PHD domain (ePHD6) in MLL3 and MLL4 specifically recogniz
Externí odkaz:
https://doaj.org/article/dd25eb29a56b4175b0c7fc357946f2ae
Autor:
Jian Han, Jia Li, Jolene Caifeng Ho, Grace Sushin Chia, Hiroyuki Kato, Sudhakar Jha, Henry Yang, Lorenz Poellinger, Kian Leong Lee
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract Adaptation to hypoxia, a hallmark feature of many tumors, is an important driver of cancer cell survival, proliferation and the development of resistance to chemotherapy. Hypoxia-induced stabilization of hypoxia-inducible factors (HIFs) lead
Externí odkaz:
https://doaj.org/article/3e8109a31875479182423eb5f4124d09
Autor:
Jolene Caifeng Ho, Lissa Nurrul Abdullah, Qing You Pang, Sudhakar Jha, Edward Kai-Hua Chow, Henry Yang, Hiroyuki Kato, Lorenz Poellinger, Jun Ueda, Kian Leong Lee
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188051 (2017)
Epigenetic mechanisms play important roles in the regulation of tumorigenesis, and hypoxia-induced epigenetic changes may be critical for the adaptation of cancer cells to the hypoxic microenvironment of solid tumors. Previously, we showed that loss-
Externí odkaz:
https://doaj.org/article/0b49f98fac7a42c19c316bb162a3080e
Autor:
Nhat Tran, Heather Whetstone, Ian Restall, Patty Sachamitr, Julian Spears, Jasmin Coulombe-Huntington, Joseph Veyhl, Gary D. Bader, Mark Bernstein, Ahmed Aman, Mike Tyers, Hannes L. Röst, Sunit Das, Kirsten Hart, Bang-Chi Duong, Zahid Quyoom Bonday, Mathieu Lupien, Peter B. Dirks, Cheryl H. Arrowsmith, Maria M. Mangos, Laura M. Richards, Owen Whitley, Paul Guilhamon, María Sánchez-Osuna, H. Artee Luchman, Trevor J. Pugh, Jolene Caifeng Ho, Michael D. Cusimano, Samuel Weiss, Philippe Thibault, Amy Caudy, Olga Zaslaver, Panagiotis Prinos, Fiona J. Coutinho, Florence M.G. Cavalli, Wenjun Chen, Victoria Vu, Dalia Barsyte-Lovejoy, Xiaoyang Lan, Xinghui Che, Mathieu Durand, Michelle Kushida, Naghmeh Rastegar, Katlin B. Massirer, Benjamin Haibe-Kains, Lilian Lee, Evgeny Kanshin, Wail Ba-alawi, Felipe Ciamponi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 (PRMT5) has recently emerged as a promising target in GBM. Using two orthogona
Autor:
Lorenz Poellinger, Seiichi Oyadomari, Hiroyuki Kato, Hisao Masai, Takashi Okamoto, Wendi Sun, Shojiro Kitajima, Jolene Caifeng Ho, Kian Leong Lee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
UTX/KDM6A encodes a major histone H3 lysine 27 (H3K27) demethylase, and is frequently mutated in various types of human cancers. Although UTX appears to play a crucial role in oncogenesis, the mechanisms involved are still largely unknown. Here we sh
Autor:
Jolene Caifeng Ho, Tsai Yu Chen, Peter Loppnau, Yanjun Li, Yanli Liu, Jinrong Min, Shilpa S. Dhar, Su Qin, Ming Lei, Min Gyu Lee, Aiping Dong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
MLL3 and MLL4 are two closely related members of the SET1/MLL family of histone H3K4 methyltransferases and are responsible for monomethylating histone H3K4 on enhancers, which are essential in regulating cell-type-specific gene expression. Mutations
Autor:
Ashley Hutchinson, Brittany Hunt, Alma Seitova, Peter Loppnau, Leticia Toledo-Sherman, Rachel Harding, Suzanne Ackloo, Alexander Lemak, Cheryl H. Arrowsmith, Alex S. Holehouse, Jolene Caifeng Ho, Lixin Fan
Publikováno v:
The Journal of biological chemistry. 294(17)
The gene mutated in individuals with Huntington’s disease (HD) encodes the 348-kDa huntingtin (HTT) protein. Pathogenic HD CAG-expansion mutations create a polyglutamine (polyQ) tract at the N terminus of HTT that expands above a critical threshold
Autor:
Lixin Fan, Cheryl H. Arrowsmith, Suzanne Ackloo, Leticia Toledo-Sherman, Alma Seitova, Brittany Hunt, Ashley Hutchinson, Alexander Lemak, Peter Loppnau, Rachel Harding, Alex S. Holehouse, Jolene Caifeng Ho
The gene mutated in Huntington’s disease (HD) patients encodes the 348 kDa huntingtin (HTT) protein. The pathogenic HD CAG-expansion mutation causes a polyglutamine (polyQ) tract at the N-terminus of the HTT protein to expand above a critical thres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39447de2b06f723a559d178cff21b494
https://doi.org/10.1101/492215
https://doi.org/10.1101/492215
Autor:
Jolene Caifeng Ho, Takis Prinos
Funding acknowledgement: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ce51505380e05ec161c57bee3799d9