Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jolanta Wiejak"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Atherosclerosis is a serious cardiovascular disease that is characterised by the development of atheroma, which are lipid-laden plaques that build up within arterial walls due to chronic inflammatory processes. These lesions are fundamentall
Externí odkaz:
https://doaj.org/article/1cced8a5e50841e3bdf709257cff5c23
Autor:
Jolanta Wiejak, Urszula Luchowska-Stańska, Pingyuan Wang, Jia Zhou, Pasquale Maffia, David Morgan, Graeme Barker, Stephen J. Yarwood
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The N-acylsulfonamide derivative, I942, represents the first non-cyclic nucleotide partial agonist of EPAC1. This was soon followed by the identification of the I942 analogues, PW0381, PW0521 and PWO577 and a series of benzofuran oxoacetic a
Externí odkaz:
https://doaj.org/article/0ea9c45cb0cf4ab2a8adfd58f7169556
Autor:
Euan Parnell, Stuart P. McElroy, Jolanta Wiejak, Gemma L. Baillie, Alison Porter, David R. Adams, Holger Rehmann, Brian O. Smith, Stephen J. Yarwood
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Screening of a carefully selected library of 5,195 small molecules identified 34 hit compounds that interact with the regulatory cyclic nucleotide-binding domain (CNB) of the cAMP sensor, EPAC1. Two of these hits (I942 and I178) were selecte
Externí odkaz:
https://doaj.org/article/c91ea91952a24175bdc43cc328f5f816
Publikováno v:
Cells, Vol 8, Iss 10, p 1253 (2019)
The novel exchange protein activated by cyclic AMP (EPAC1) activator, I942, induces expression of the suppressor of cytokine signalling 3 (SOCS3) gene, thereby inhibiting interleukin 6 (IL6) inflammatory processes in human umbilical vein endothelial
Externí odkaz:
https://doaj.org/article/de9a6d47c8be4ca29f9ee4d66e141f88
Autor:
Holger Rehmann, Graeme Barker, Haiying Chen, Stephen J. Yarwood, Jia Zhou, Boy van Basten, Jolanta Wiejak, Emma Lochhead, David Morgan, Padraic Whelan, Zhiqing Liu, Urszula Luchowska-Stańska, Pingyuan Wang
Publikováno v:
Journal of Medicinal Chemistry. 63:5159-5184
Exchange proteins directly activated by cAMP (EPAC) play a central role in various biological functions, and activation of the EPAC1 protein has shown potential benefits for the treatment of various human diseases. Herein, we report the synthesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fbc6e7ea23a19108b7bae605c2b64b
https://doi.org/10.1021/acs.jmedchem.9b02094
https://doi.org/10.1021/acs.jmedchem.9b02094
Autor:
John Robinson, Stuart P. McElroy, Philip S. Jones, Graeme Barker, Euan Parnell, Helma Rutjes, Lindsay Robinson, Angus Morrison, Elizabeth M. Beck, Andrew D. Pannifer, Martin Timmerman, Angela Cowley, Jolanta Wiejak, Veronique Hamon, Holger Rehmann, Urszula Luchowska-Stańska, Jonathan Gillespie, David Morgan, Stephen J. Yarwood, Alison Porter, Pravin Mahajan
Publikováno v:
Cells
Volume 8
Issue 11
Volume 8
Issue 11
Cyclic AMP promotes EPAC1 and EPAC2 activation through direct binding to a specific cyclic nucleotide-binding domain (CNBD) within each protein, leading to activation of Rap GTPases, which control multiple cell responses, including cell proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677a116fcb1675edbcc36ca4fb30482f
https://pubmed.ncbi.nlm.nih.gov/31726720
https://pubmed.ncbi.nlm.nih.gov/31726720
Publikováno v:
Cells
Volume 8
Issue 10
Cells, Vol 8, Iss 10, p 1253 (2019)
Volume 8
Issue 10
Cells, Vol 8, Iss 10, p 1253 (2019)
The novel exchange protein activated by cyclic AMP (EPAC1) activator, I942, induces expression of the suppressor of cytokine signalling 3 (SOCS3) gene, thereby inhibiting interleukin 6 (IL6) inflammatory processes in human umbilical vein endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fdca88bae4316e7468a6875af101c0
https://eprints.gla.ac.uk/200720/1/200720.pdf
https://eprints.gla.ac.uk/200720/1/200720.pdf
Autor:
Boy van Basten, Jolanta Wiejak, Stephen J. Yarwood, Graham Hamilton, Urszula Luchowska-Stańska
Publikováno v:
Biochimica et Biophysica Acta. Molecular Cell Research
Exchange protein activated by cyclic AMP (EPAC1) suppresses multiple inflammatory actions in vascular endothelial cells (VECs), partly due to its ability to induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene, the protein produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf432d5ecfcc76e1a4b6d3d0edb87b6a
https://pubmed.ncbi.nlm.nih.gov/30414891
https://pubmed.ncbi.nlm.nih.gov/30414891
Autor:
Alison Porter, Brian O. Smith, Stephen J. Yarwood, Jolanta Wiejak, Euan Parnell, David R. Adams, Gemma L. Baillie, Holger Rehmann, Stuart P. McElroy
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Screening of a carefully selected library of 5,195 small molecules identified 34 hit compounds that interact with the regulatory cyclic nucleotide-binding domain (CNB) of the cAMP sensor, EPAC1. Two of these hits (I942 and I178) were selected for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedb5c2dbfe65e9841ae33e7bae52752
https://pubmed.ncbi.nlm.nih.gov/28331191
https://pubmed.ncbi.nlm.nih.gov/28331191
Autor:
Julia Dunlop, Jolanta Wiejak, Chloe L Stoyle, John D. Pediani, Gillian Lappin, Stephen J. Yarwood, Shan Gao, Anna McIlroy
Publikováno v:
Cellular Signalling
Induction of the suppressor of cytokine signalling 3 (SOCS-3) gene is vital to the normal control of inflammatory signalling. In order to understand these processes we investigated the role of the proto-oncogene component of the AP-1 transcription fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebecb5c1ef9d6bc7cf3ecd3e42b5f72
https://doi.org/10.1016/j.cellsig.2012.04.016
https://doi.org/10.1016/j.cellsig.2012.04.016