Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jolanta Maria Wodzinska"'
Autor:
Regis Leung-Toung, Michael Spino, Jolanta Maria Wodzinska, Jayme Lowrie, Khashayar Karimian, Craig D. Simpson, Tim Fat Tam, Yanqing Zhao
Publikováno v:
Journal of Medicinal Chemistry. 48:2266-2269
A new class of selective FXIIIa inhibitors with a bicyclic [1,2,4]-thiadiazole pharmacophore is described. At 160 muM, compound 8 caused 50% reduction in fibrin gamma-chain cross-linking and suppressed the polymerization of alpha chains in platelet-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528692eb5cde3ad91d7b2fe2484b4229
https://doi.org/10.1021/jm049221w
https://doi.org/10.1021/jm049221w
Autor:
Desilets Denis, Wanren Li, Khashayar Karimian, Rahul Kukreja, Tim Fat Tam, Regis Leung-Toung, Jolanta Maria Wodzinska, Jayme Lowrie
Publikováno v:
Bioorganicmedicinal chemistry. 11(24)
A novel class of Cathepsin B inhibitors has been developed with a 1,2,4-thiadiazole heterocycle as the thiol trapping pharmacophore. Several compounds with different dipeptide recognition sequence (i.e., P1′ – P2′= Leu-Pro-OH or P2 – P1 =Cbz-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebbe1055995a8422b512ef44bbddb7f
https://pubmed.ncbi.nlm.nih.gov/14642597
https://pubmed.ncbi.nlm.nih.gov/14642597