Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jolanta Grzybowska"'
Autor:
Rajendra Prasad, Jolanta Grzybowska, Magdalena Slisz, Jacek Czub, Edward Borowski, Barbara Cybulska
Publikováno v:
The Journal of Antibiotics. 60:436-446
Comparative studies were performed to determine the activity and cytotoxicity of amphotericin B (AmB) and its derivatives on standard strain of Saccharomyces cerevisiae and its transformants with cloned genes from Candida albicans encoding multidrug
Publikováno v:
Journal of Colloid and Interface Science. 287:476-484
N-(1-piperidinepropionyl)amphotericin B methyl ester (in short, PAME), a low-toxicity amphotericin B derivative, has been investigated in Langmuir monolayers at the air/water interface alone and in mixtures with cellular membrane sterols (a mammalian
Autor:
Edward Borowski, Joanna Szlinder-Richert, Barbara Cybulska, Jolanta Grzybowska, Jacques Bolard
Publikováno v:
Il Farmaco. 59:289-296
Amphotericin B (AMB) derivative, N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME) retains the broad antifungal spectrum and potency of the parent antibiotic, whereas its toxicity towards mammalian cells is reduced by about two orders of mag
Publikováno v:
The Journal of Antibiotics. 57:669-678
The novel group of amphotericin B (AmB) cationic derivatives has been examined in terms of relationship between self-association and selective toxicity. In all determinations AmB has been used as reference compound. In vitro toxic effects of the comp
Autor:
Edward Borowski, Joanna Szlinder-Richert, Barbara Cybulska, Rajendra Prasad, Jolanta Grzybowska
Publikováno v:
Acta Biochimica Polonica. 47:133-140
N-Methyl-N-D-fructosyl-amphotericin B methyl ester (MFAME) is a new derivative of amphotericin B, which is characterised by low toxicity to mammalian cells and good solubility in water of its salts. The antifungal activity and effects of MFAME toward
In this paper we present the characteristics of the Langmuir monolayers formed by amphotericin B 3-( N ', N '-dimethylamino) propyl amide (AMA) that is a derivative of amphotericin B (AmB), a polyene antifungal antibiotic. Also, the interactions of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba84a8cc5900f73878bc9250be91992
https://ruj.uj.edu.pl/xmlui/handle/item/80589
https://ruj.uj.edu.pl/xmlui/handle/item/80589
Publikováno v:
European Biophysics Journal. 18:159-164
The poor solubility of polyene antibiotics in aqueous media limits their application in the therapy of systemic fungal infections. In the present paper we have demonstrated that the ionic state (net electrical charge) of the antibiotic molecule is an
Publikováno v:
The Journal of Antibiotics. 50:709-711
Publikováno v:
Colloids and surfaces. B, Biointerfaces. 46(1)
This work presents the results of Langmuir monolayers study of two amphotericin B derivatives obtained by N-acylation (N-acetylamphotericin B, Ac-AmB) and esterification (amphotericin B methyl ester, AME) of the parent AmB molecule. The main objectiv
Autor:
Ali R. Banijamali, Albert J. Nitowski, Pusheng Fan, Yan Guo, Xiuyan Li, Ravi Chari, Jolanta Grzybowska, Gilbert Marciniak, Avgui Charalambous, Therapia Kourouli, Spyros P. Nikas, Sonyuan Lin, Demetris P. Papahatjis, Alexandros Makriyannis, Chia-Lin J. Wang
Publikováno v:
The AAPS journal. 6(4)
The presence of halogens within the classical cannabinoid structure leads to large variations in the compounds' potencies and affinities for the CB1 receptors. To explore the structure activity relationships within this class of analogs we have used