Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Jolanda van Hengel"'
Autor:
Jeffrey Aalders, Laurens Léger, Behrouz Hassannia, Vera Goossens, Tom Vanden Berghe, Jolanda van Hengel
Publikováno v:
Regenerative Therapy, Vol 27, Iss , Pp 21-31 (2024)
Generation of cardiomyocytes from human pluripotent stem cells (hPSCs) is of high interest for disease modelling and regenerative medicine. hPSCs can provide an unlimited source of patient-specific cardiomyocytes that are otherwise difficult to obtai
Externí odkaz:
https://doaj.org/article/560e0a859b58470e9d2823b7cf229719
Autor:
Laurens Léger, Jeffrey Aalders, Nina Heymans, Kiara Van Acker-Verberckt, Léa De Bleeckere, Paul Coucke, Björn Menten, Barbara Bauce, Libero Vitiello, Alessandra Rampazzo, Martina Calore, Jolanda van Hengel
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103537- (2024)
Arrhythmogenic cardiomyopathy is a severe genetic heart muscle disease characterized by fibro-fatty replacement of the myocardium. Pathogenic variants causal for this disease are mainly located in desmosomal genes, including desmoplakin (DSP). Renal
Externí odkaz:
https://doaj.org/article/f84b89a06f57461ea51006e28aa511b5
Autor:
Laurens Léger, Chloë De Clercq, Jeffrey Aalders, Kiara Van Acker-Verberckt, Kevin Braeckmans, Jolanda van Hengel
Publikováno v:
MethodsX, Vol 12, Iss , Pp 102548- (2024)
Human induced pluripotent stem cell-derived cardiomyocytes (iPSCCMs) are promising candidates for disease modeling and therapeutic purposes, however, non-viral intracellular delivery in these cells remains challenging. Gold nanoparticle (AuNP)-sen
Externí odkaz:
https://doaj.org/article/bc69f80ebb354e01a4e2b5c3c9d3de55
Autor:
Jeffrey Aalders, Laurens Léger, Anthony Demolder, Laura Muiño Mosquera, Paul Coucke, Björn Menten, Julie De Backer, Jolanda van Hengel
Publikováno v:
Stem Cell Research, Vol 67, Iss , Pp 103036- (2023)
Marfan syndrome is an autosomal dominant genetic disorder resulting from pathogenic variants in FBN1 gene. FBN1 encodes for fibrillin-1, an important extracellular matrix protein. Impaired fibrillin-1 affects multiple organ systems, including the car
Externí odkaz:
https://doaj.org/article/8fb41cfcc7454bccb41cffab74b956df
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Considerable progress has been made in our knowledge of the morphological and functional varieties of anchoring junctions. Cell-cell adhesion contacts consist of discrete junctional structures responsible for the mechanical coupling of cytoskeletons
Externí odkaz:
https://doaj.org/article/45c1618ac2fe4ff4ba3c31ba86ec36d8
Autor:
Karen De Samblancx, Marion Mesnieres, Dana Trompet, Naomi Dirckx, Katrien Corbeels, Elena Nefyodova, Ruben Cardoen, Jolanda van Hengel, Frans van Roy, Greetje Vande Velde, Bart Van der Schueren, Chantal Mathieu, Christa Maes
Publikováno v:
Bone Reports, Vol 13, Iss , Pp 100329- (2020)
Externí odkaz:
https://doaj.org/article/ebbe610fc8464335a764b16d6e5272d9
Publikováno v:
MethodsX, Vol 7, Iss , Pp 101065- (2020)
Three-dimensional (3D) cell culturing has several advantages over 2D cultures. 3D cell cultures more accurately mimic the in vivo environment, which is vital to obtain reliable results in disease modelling and toxicity testing. With the introduction
Externí odkaz:
https://doaj.org/article/62fa05f8152d413294568992b9a6dc51
p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification.
Autor:
Tim Pieters, Steven Goossens, Lieven Haenebalcke, Vanessa Andries, Agata Stryjewska, Riet De Rycke, Kelly Lemeire, Tino Hochepied, Danny Huylebroeck, Geert Berx, Marc P Stemmler, Dagmar Wirth, Jody J Haigh, Jolanda van Hengel, Frans van Roy
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006243 (2016)
E-cadherin-mediated cell-cell adhesion is critical for naive pluripotency of cultured mouse embryonic stem cells (mESCs). E-cadherin-depleted mESC fail to downregulate their pluripotency program and are unable to initiate lineage commitment. To furth
Externí odkaz:
https://doaj.org/article/16ca3ab9fb204856afe1e62fd0ee6214
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0148114 (2016)
We analyzed the protein distribution of two cadherin-associated molecules, plakoglobin and β-catenin, during the different stages of tooth development and tooth replacement in zebrafish. Plakoglobin was detected at the plasma membrane already at the
Externí odkaz:
https://doaj.org/article/528d8c32d00e4afe8c9b780e051a9749
Autor:
Adelheid Soubry, Katrien Staes, Eef Parthoens, Sam Noppen, Christophe Stove, Pieter Bogaert, Jolanda van Hengel, Frans van Roy
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9203 (2010)
Kaiso is a BTB/POZ zinc finger protein known as a transcriptional repressor. It was originally identified through its in vitro association with the Armadillo protein p120ctn. Subcellular localization of Kaiso in cell lines and in normal and cancerous
Externí odkaz:
https://doaj.org/article/ebabc906c64343f496a5e9dec5afcf73