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Omentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment.

Autor: Neilson LJ; Cancer Research UK Scotland Institute, Glasgow, UK., Cartwright D; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Risteli M; Research Unit of Population Health, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland., Jokinen EM; Department of Bacteriology and Immunology, Translational Immunology Research Program, University of Helsinki, Finland., McGarry L; Cancer Research UK Scotland Institute, Glasgow, UK., Sandvik T; Research Unit of Population Health, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland., Nikolatou K; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Hodge K; Cancer Research UK Scotland Institute, Glasgow, UK., Atkinson S; Cancer Research UK Scotland Institute, Glasgow, UK., Vias M; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, UK., Kay EJ; Cancer Research UK Scotland Institute, Glasgow, UK., Brenton JD; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, UK., Carlin LM; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Bryant DM; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Salo T; Research Unit of Population Health, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.; Department of Pathology, University of Helsinki, Helsinki, Finland.; Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Zanivan S; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.

Publikováno v: Matrix biology plus [Matrix Biol Plus] 2023 Nov 22; Vol. 19-20, pp. 100136. Date of Electronic Publication: 2023 Nov 22 (Print Publication: 2023).

Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13.

Autor: Juvonen RO; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Jokinen EM; Institute of Biomedicine, Faculty of Medicine, Integrative Physiology and Pharmacology, University of Turku, Turku, Finland., Huuskonen J; Department of Chemistry, University of Jyvaskyla, Jyvaskyla, Finland., Kärkkäinen O; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Raunio H; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Pentikäinen OT; Institute of Biomedicine, Faculty of Medicine, Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.; Department of Chemistry, University of Jyvaskyla, Jyvaskyla, Finland.

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Nov; Vol. 51 (11), pp. 1207-1216. Date of Electronic Publication: 2021 Nov 02.

Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling.

Autor: Juvonen RO; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Box 1627, 70211 Kuopio, Finland., Ahinko M; Department of Biological and Environmental Science & Nanoscience Center, University of Jyvaskyla, P.O. Box 35, FI-40014 Jyvaskyla, Finland., Jokinen EM; Institute of Biomedicine, Faculty of Medicine, Integrative Physiology and Pharmacology, University of Turku, Kiinamyllynkatu 10, FI-20520 Turku, Finland., Huuskonen J; Department of Chemistry, University of Jyvaskyla, P.O. Box 35, FI-40014 Jyvaskyla, Finland., Raunio H; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Box 1627, 70211 Kuopio, Finland., Pentikäinen OT; Department of Biological and Environmental Science & Nanoscience Center, University of Jyvaskyla, P.O. Box 35, FI-40014 Jyvaskyla, Finland.; Institute of Biomedicine, Faculty of Medicine, Integrative Physiology and Pharmacology, University of Turku, Kiinamyllynkatu 10, FI-20520 Turku, Finland.

Publikováno v: ACS omega [ACS Omega] 2021 Apr 19; Vol. 6 (17), pp. 11286-11296. Date of Electronic Publication: 2021 Apr 19 (Print Publication: 2021).

Inhibition of human CYP1 enzymes by a classical inhibitor α-naphthoflavone and a novel inhibitor N-(3, 5-dichlorophenyl)cyclopropanecarboxamide: An in vitro and in silico study.

Autor: Juvonen RO; Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland., Jokinen EM; Faculty of Medicine, Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland., Javaid A; Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland., Lehtonen M; Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.; LC-MS Metabolomics Center, Biocenter Kuopio, Kuopio, Finland., Raunio H; Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland., Pentikäinen OT; Faculty of Medicine, Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.

Publikováno v: Chemical biology & drug design [Chem Biol Drug Des] 2020 May; Vol. 95 (5), pp. 520-533. Date of Electronic Publication: 2020 Mar 09.