Ex vivo modeling of precision immuno-oncology responses in lung cancer.

Autor: Alsaed B; Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland., Smolander J; Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland., Laitinen H; Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland., Lin L; Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland., Bobik N; Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland., Lahtinen L; Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland., Räsänen M; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Department of General Thoracic and Esophageal Surgery, Heart and Lung Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Jansouz S; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Translational Cancer Medicine Program (CAN-PRO), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Peltonen K; Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland., Jokinen E; Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland., Klievink J; Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland., Ganesh K; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Translational Cancer Medicine Program (CAN-PRO), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Wihuri Research Institute, Biomedicum Helsinki, Haartmaninkatu 8, Helsinki, Finland., Ainola M; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, and Department of Pulmonary Medicine, Heart and Lung Centre, Helsinki University Hospital, Helsinki, Finland., Sutinen E; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, and Department of Pulmonary Medicine, Heart and Lung Centre, Helsinki University Hospital, Helsinki, Finland., Rönty M; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Narvi E; Immuno-Oncology, Oncology Research, Orion Corporation, Turku, Finland., Thotakura A; Immuno-Oncology, Oncology Research, Orion Corporation, Turku, Finland., Saharinen P; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Translational Cancer Medicine Program (CAN-PRO), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Wihuri Research Institute, Biomedicum Helsinki, Haartmaninkatu 8, Helsinki, Finland., Mustjoki S; Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland., Ilonen I; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; Department of General Thoracic and Esophageal Surgery, Heart and Lung Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Haikala HM; Translational Immunology Research Program (TRIMM), Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.

Publikováno v: Science advances [Sci Adv] 2024 Nov; Vol. 10 (44), pp. eadq6830. Date of Electronic Publication: 2024 Oct 30.

Change in cognitive performance during seven-year follow-up in midlife is associated with sex, age, and education - The Cardiovascular Risk in Young Finns Study.

Autor: Heiskanen MA; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland. marja.heiskanen@utu.fi.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. marja.heiskanen@utu.fi., Nevalainen J; Unit of Health Sciences, Tampere University, Tampere, Finland., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Paavo Nurmi Centre, Unit for Health and Physical Activity, University of Turku, Turku, Finland., Juonala M; Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland., Hutri N; Tampere Centre for Skills Training and Simulation, Tampere University, Tampere, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Jokinen E; Department of Pediatric Cardiology, Hospital for Children and Adolescents, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Laitinen TP; Department of Clinical Physiology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Tossavainen P; Department of Pediatrics, Research Unit of Clinical Medicine, MRC Oulu, University of Oulu, Oulu, Finland.; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland., Taittonen L; Department of Pediatrics, Tampere University Hospital, Tampere, Finland., Viikari JSA; Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Rovio SP; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland.

Publikováno v: Journal of neurology [J Neurol] 2024 Aug; Vol. 271 (8), pp. 5165-5176. Date of Electronic Publication: 2024 Jun 02.

Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study.

Autor: Niemelä J; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.; Heart Center, Turku University Hospital and University of Turku, Turku, Finland., Nuotio J; Heart Center, Turku University Hospital and University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Laitinen TT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Paavo Nurmi Centre, Unit for Health and Physical Activity, University of Turku, Turku, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Hutri N; Department of Paediatrics, University of Tampere and Tampere University Hospital, Tampere, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Jokinen E; Department of Pediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland., Tossavainen P; Department of Paediatrics, University of Oulu, Oulu, Finland., Laitinen TP; Department of Clinical Physiology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Heinonen OJ; Paavo Nurmi Centre, Unit for Health and Physical Activity, University of Turku, Turku, Finland., Dwyer T; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom., Pahkala K; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Paavo Nurmi Centre, Unit for Health and Physical Activity, University of Turku, Turku, Finland., Rovio SP; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Viikari J; Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland., Raitakari O; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Juonala M; Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland.

Publikováno v: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2024 Jul 01; Vol. 33 (7), pp. 923-932.

Exposure to parental smoking and cardiac structure and function in adulthood: the Cardiovascular Risk in Young Finns Study.

Autor: Pihlman J; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Finland., Nuotio J; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Finland., Rovio S; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Finland., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Finland., Ruohonen S; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Finland., Jokinen E; Department of Paediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Finland., Laitinen TP; Department of Clinical Physiology, University of Eastern Finland and Kuopio University Hospital, Finland., Burgner DP; Murdoch Children's Research Institute, The Royal Children's Hospital, Australia.; Department of Paediatrics, University of Melbourne, Australia., Hutri-Kähönen N; Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Finland., Tossavainen P; Department of Pediatrics, PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Finland., Taittonen L; Department of Pediatrics, PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Finland.; Vaasa Central Hospital, Finland., Kähönen M; Department of Clinical Physiology, Faculty of Medicine and Health Technology, Tampere University, Finland., Viikari JSA; Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Finland., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland., Magnussen CG; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Finland.; Menzies Institute for Medical Research, University of Tasmania, Australia., Juonala M; Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Finland.

Publikováno v: Scandinavian journal of public health [Scand J Public Health] 2024 Feb; Vol. 52 (1), pp. 15-23. Date of Electronic Publication: 2022 Sep 07.

Association of number of siblings with preclinical markers of cardiovascular disease. The cardiovascular risk in Young Finns study.

Autor: Pihlman J; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Magnussen CG; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Baker Heart and Diabetes Institute, Melbourne, Australia., Laitinen TT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Ruohonen S; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland., Jokinen E; Department of Paediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland., Laitinen TP; Department of Clinical Physiology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Hutri-Kähönen N; Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Tossavainen P; Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, MRC Oulu and Research Unit of Clinical Medicine, University of Oulu, Finland., Taittonen L; Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, MRC Oulu and Research Unit of Clinical Medicine, University of Oulu, Finland.; Vaasa Central Hospital, Vaasa, Finland., Kähönen M; Department of Clinical Physiology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Viikari JS; Department of Internal Medicine, University of Turku, Turku, Finland.; Division of Medicine, Turku University Hospital, Turku, Finland., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland., Juonala M; Department of Internal Medicine, University of Turku, Turku, Finland.; Division of Medicine, Turku University Hospital, Turku, Finland., Nuotio J; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Heart Center, Turku University Hospital and University of Turku, Turku, Finland.

Publikováno v: International journal of cardiology. Cardiovascular risk and prevention [Int J Cardiol Cardiovasc Risk Prev] 2023 Dec 08; Vol. 20, pp. 200227. Date of Electronic Publication: 2023 Dec 08 (Print Publication: 2024).