Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance.

Autor: Jiang K; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore.; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore, 119276, Singapore., Lim SB; Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, South Korea., Xiao J; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore., Jokhun DS; Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore., Shang M; Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.; Critical Analytics for Manufacturing Personalized-Medicine (CAMP) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore, 138602, Singapore., Song X; Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore., Zhang P; NUS Graduate School for Integrative Sciences & Engineering (NGS), National University of Singapore, Singapore, 119077, Singapore., Liang L; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore., Low BC; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore.; Department of Biological Science, National University of Singapore, Singapore, 117558, Singapore., Shivashankar GV; Department of Health Sciences & Technology (D-HEST), ETH Zurich, Villigen, 8092, Switzerland.; Division of Biology and Chemistry, Paul Scherrer Institute, Villigen, 5232, Switzerland., Lim CT; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore.; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore, 119276, Singapore.; Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.; NUS Graduate School for Integrative Sciences & Engineering (NGS), National University of Singapore, Singapore, 119077, Singapore.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Aug; Vol. 10 (22), pp. e2201663. Date of Electronic Publication: 2023 May 23.

Machine learning based approach to pH imaging and classification of single cancer cells.

Autor: Belotti Y; Institute for Health Innovation and Technology, National University of Singapore, 117599 Singapore, Singapore., Jokhun DS; Department of Biomedical Engineering, National University of Singapore, 117583 Singapore, Singapore., Ponnambalam JS; Department of Biomedical Engineering, National University of Singapore, 117583 Singapore, Singapore., Valerio VLM; Department of Biomedical Engineering, National University of Singapore, 117583 Singapore, Singapore., Lim CT

Publikováno v: APL bioengineering [APL Bioeng] 2021 Mar 16; Vol. 5 (1), pp. 016105. Date of Electronic Publication: 2021 Mar 16 (Print Publication: 2021).

Multivariate analysis reveals activation-primed fibroblast geometric states in engineered 3D tumor microenvironments.

Autor: Venkatachalapathy S; Mechanobiology Institute and Department of Biological Sciences, National University of Singapore, 117411, Singapore., Jokhun DS; Mechanobiology Institute and Department of Biological Sciences, National University of Singapore, 117411, Singapore., Shivashankar GV; Mechanobiology Institute and Department of Biological Sciences, National University of Singapore, 117411, Singapore.; FIRC Institute for Molecular Oncology, Milan 20139, Italy.; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.; Paul Scherrer Institut, 5232 Villigen, Switzerland.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2020 Apr 01; Vol. 31 (8), pp. 803-812. Date of Electronic Publication: 2020 Feb 05.

Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints.

Autor: Alisafaei F; Department of Materials Science and Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104.; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA 19104., Jokhun DS; Mechanobiology Institute, National University of Singapore, 117411, Singapore., Shivashankar GV; Mechanobiology Institute, National University of Singapore, 117411, Singapore.; Department of Biological Sciences, National University of Singapore, 117411, Singapore.; FIRC Institute for Molecular Oncology (IFOM), 20139 Milan, Italy., Shenoy VB; Department of Materials Science and Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104; vshenoy@seas.upenn.edu.; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA 19104.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jul 02; Vol. 116 (27), pp. 13200-13209. Date of Electronic Publication: 2019 Jun 17.

Localized mechanical stimulation of single cells with engineered spatio-temporal profile.

Autor: Monticelli M; Department of Physics, Politecnico di Milano, Milan, Italy. marco.monticelli@polimi.it., Jokhun DS, Petti D, Shivashankar GV, Bertacco R

Publikováno v: Lab on a chip [Lab Chip] 2018 Sep 26; Vol. 18 (19), pp. 2955-2965.