Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Joke Regts"'
Autor:
Stephanie van de Wall, Janneke M. Meulenberg, Baukje Nynke Hoogeboom, Jessica Sluis, Coba J. van Zanten, Joke Regts, Marco de Bruyn, Toos Daemen, Fenne L. Komdeur, Jos G. W. Kosterink, Amrita Singh, Ed Schuuring, Jan Wilschut, Derk P. Allersma, Ruben Marra, Annemarie Boerma, Ate G.J. van der Zee, Annelies Jorritsma-Smit, Cesar Oyarce, Hans W. Nijman, N Werner, R. Yigit, S. T. Paijens
Publikováno v:
Mol Ther
Molecular Therapy, 29(2), 611-625. CELL PRESS
Molecular therapy, 29(2), 611-625. Nature Publishing Group
Molecular Therapy
Molecular Therapy, 29(2), 611-625. CELL PRESS
Molecular therapy, 29(2), 611-625. Nature Publishing Group
Molecular Therapy
A first-in-human phase I trial of Vvax001, an alphavirus-based therapeutic cancer vaccine against human papillomavirus (HPV)-induced cancers was performed assessing immunological activity, safety, and tolerability. Vvax001 consists of replication-inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f10409c4d65c0a9e0ce6eaeda670e28
https://hdl.handle.net/11370/5172de71-9650-4d26-b08d-9a20ba7f7564
https://hdl.handle.net/11370/5172de71-9650-4d26-b08d-9a20ba7f7564
Autor:
Jan Wilschut, Annemarie Boerma, Joke Regts, Toos Daemen, Tjarko Meijerhof, Peng Peng Ip, Hans W. Nijman
Publikováno v:
Molecular Therapy, 22(4), 881-890. CELL PRESS
An absolute prerequisite for a therapeutic vaccine against hepatitis C virus (HCV) infection is the potency to induce HCV-specific vigorous and broad-spectrum T-cell responses. Here, we generated three HCV vaccines based on a recombinant Semliki Fore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8bda3b09fa34ef5de0f95dacb8bbc8
https://doi.org/10.1038/mt.2013.287
https://doi.org/10.1038/mt.2013.287
Autor:
Jan Wilschut, Arjan de Mare, Annelies Riezebos-Brilman, Joke Regts, Mateusz Walczak, Marc Fiedler, Toos Daemen, Baukje Nynke Hoogeboom, Jeroen Visser, Ate G.J. van der Zee, Pidder Jansen-Duerr, Hans W. Nijman
Publikováno v:
Molecular pharmaceutics, 8(1), 65-77. AMER CHEMICAL SOC INC
Heterologous prime-boost immunization strategies in general establish higher frequencies of antigen-specific T lymphocytes than homologous prime-boost protocols or single immunizations. We developed virosomes and recombinant Semliki Forest virus (rSF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ad3c41721bad658a3bd44c98508743
https://research.rug.nl/en/publications/a8d4b882-c2a8-4567-8c42-a018c8a5420a
https://research.rug.nl/en/publications/a8d4b882-c2a8-4567-8c42-a018c8a5420a
Publikováno v:
Vaccine, 27(5), 701-707. ELSEVIER SCI LTD
To enhance the efficacy of a therapeutic immunisition strategy against human papillomavirus-induced cervical cancer we evaluated the adjuvant effect of interleukin-12 (IL12) expressed by a Semliki Forest virus vector (SFV) in mice. Depending on the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e221c193538bcc65eb318e1eb9df81eb
https://doi.org/10.1016/j.vaccine.2008.11.032
https://doi.org/10.1016/j.vaccine.2008.11.032
Autor:
Arjan de Mare, Laura Bungener, Jan Witschut, Toos Daemen, Jacqueline de Vries-Idema, Joke Regts, Ate G.J. van der Zee
Publikováno v:
Vaccine, 26(19), 2314-2321. ELSEVIER SCI LTD
Protein antigens encapsulated in virosomes generated from influenza virus can induce antigen-specific cytotoxic T lymphocyte (CTL) responses. In the present study we determined, in a murine model system, whether pre-existing immunity against influenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cae544a108351d54232b9c94bd7a61
https://research.rug.nl/en/publications/4d3229bf-1c0a-4dc6-a980-4b982990c124
https://research.rug.nl/en/publications/4d3229bf-1c0a-4dc6-a980-4b982990c124
Autor:
Mateusz Walczak, Bert Dontje, Jan Wilschut, Annelies Riezebos-Brilman, Joke Regts, Gera Kamps, Toos Daemen, Marianne G. Rots, Hidde J. Haisma
Publikováno v:
Gene Therapy, 14(24), 1695-1704. Nature Publishing Group
Currently, various therapeutic strategies are being explored as a potential means to immunize against metastatic malignant cells or even primary tumours. Using recombinant viral vectors systems or protein-based immunization approaches, we are develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a70496cbf003a0eab9eda905d40036e
https://doi.org/10.1038/sj.gt.3303036
https://doi.org/10.1038/sj.gt.3303036
Publikováno v:
British Jounal of Cancer, 79(1), 89-94. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer
We studied the effect of recombinant murine granulocyte–macrophage colony-stimulating factor(rmGM-CSF) on the cytotoxic potential of murine peritoneal cells. Mice received rmGM-CSF intraperitoneally using different dosages and injection schemes. At
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7ee9864358d561ae651fc5d32e9583
https://doi.org/10.1038/sj.bjc.6690016
https://doi.org/10.1038/sj.bjc.6690016
Autor:
Toos Daemen, Gerrit L. Scherphof, M.H. de Jager, Maria J. Velinova, Joke Regts, Jan Donga, J. J. L. van der Want, R Kalicharan
Publikováno v:
Hepatology, 26(2), 416-423. Wiley
Liposomes with diameters of 200 to 400 nm containing phosphatidylserine (PS) or phosphatidylglycerol (PG) were injected intravenously into rats, Two hours after injection, T5% of the injected dose of PS liposomes was found in the liver and only 10% f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c566ead0c42d3636693f8aff4b144f6
https://doi.org/10.1002/hep.510260223
https://doi.org/10.1002/hep.510260223
Autor:
Jan Wilschut, Antoon J. M. van Oosterhout, Toos Daemen, Louis Boon, Joke Regts, Hans W. Nijman, Mateusz Walczak
Publikováno v:
Antiviral therapy, 16(2), 207-218
Background Regulatory T-cells (Treg) hamper immune responses elicited by cancer vaccines. Therefore, depletion of Treg is being used to improve the outcome of vaccinations. Methods We studied whether an alphavirus vector-based immunotherapeutic vacci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ed5a336792c5d81052cc679fb26e45
https://research.rug.nl/en/publications/f523ccc0-c5b4-422d-b5ab-fe0982ab83e8
https://research.rug.nl/en/publications/f523ccc0-c5b4-422d-b5ab-fe0982ab83e8
Publikováno v:
Journal of Immunotherapy, 13(1), 31-35. LIPPINCOTT WILLIAMS & WILKINS
The therapeutic effect of a combination of liposomal muramyl dipeptide (MDP) and 5-fluorouracil (5FU) was studied in a murine tumor model of hepatic metastases of the tumor cell line C26, a colon adenocarcinoma. Liposomal MDP (250 mug/kg body wt) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ebc18ceb1678f99e72637d13905078
https://doi.org/10.1097/00002371-199301000-00004
https://doi.org/10.1097/00002371-199301000-00004