Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Joke M M, den Haan"'
Autor:
Joanna Grabowska, Valentine Léopold, Katarzyna Olesek, Maarten K. Nijen Twilhaar, Alsya J. Affandi, Mieke C. Brouwer, Ilse Jongerius, Admar Verschoor, Cees van Kooten, Yvette van Kooyk, Gert Storm, Cornelis van ‘t Veer, Joke M. M. den Haan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Historically platelets are mostly known for their crucial contribution to hemostasis, but there is growing understanding of their role in inflammation and immunity. The immunomodulatory role of platelets entails interaction with pathogens, but also w
Externí odkaz:
https://doaj.org/article/3541dcb491b24ae2993ad7cfff31a80a
Autor:
Manfred Wuhrer, Louis Boon, Di Wang, Yvette van Kooyk, Ernesto Rodriguez, Joke M M Den Haan, Nadine van Montfoort, Sandra J van Vliet, Kelly Boelaars, Laura Goossens-Kruijssen, Charlotte M de Winde, Dimitri Lindijer, Babet Springer, Irene van der Haar Àvila, Aram de Haas, Laetitia Wehry, Reina E Mebius
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Despite the successful application of immune checkpoint blockade in a range of human cancers, immunotherapy in PDAC remains unsuccessful. PDAC is characterized by a d
Externí odkaz:
https://doaj.org/article/13e463cc897642b5b08aea0a5c85d90b
Autor:
Rob C Hoeben, Sjoerd H van der Burg, Marjolein Sluijter, Thorbald van Hall, Joke M M Den Haan, Camilla Labrie, Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Nadine van Montfoort, Lisa Griffioen, Jordi J C van Stigt Thans
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Many solid tumors do not respond to immunotherapy due to their immunologically cold tumor microenvironment (TME). We and others found that oncolytic viruses (OVs), including reovirus type 3 Dearing, can enhance the efficacy of immunotherap
Externí odkaz:
https://doaj.org/article/3366d822d5c7405c92a4c4b02eb41013
Autor:
Maarten K. Nijen Twilhaar, Lucas Czentner, Rianne G. Bouma, Katarzyna Olesek, Joanna Grabowska, Aru Zeling Wang, Alsya J. Affandi, Saskia C. Belt, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm, Joke M. M. den Haan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cancer vaccination aims to activate immunity towards cancer cells and can be achieved by delivery of cancer antigens together with immune stimulatory adjuvants to antigen presenting cells (APC). APC maturation and antigen processing is a subsequent p
Externí odkaz:
https://doaj.org/article/42a73ed18e1e4c2ba3e4049a3d626210
Autor:
Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Joris J. T. H. Roelofs, Onno J. de Boer, Joke M. M. den Haan, Rudi W. Hendriks, Cornelis van ‘t Veer, Tom van der Poll, Alex F. de Vos
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Bruton’s tyrosine kinase (Btk) is a cytoplasmic kinase expressed in B cells and myeloid cells. It is essential for B cell development and natural antibody-mediated host defense against bacteria in humans and mice, but little is known about the role
Externí odkaz:
https://doaj.org/article/6534ee5b3c2444c6b14ce70febc59ba2
Autor:
Alsya J. Affandi, Katarzyna Olesek, Joanna Grabowska, Maarten K. Nijen Twilhaar, Ernesto Rodríguez, Anno Saris, Eline S. Zwart, Esther J. Nossent, Hakan Kalay, Michael de Kok, Geert Kazemier, Johannes Stöckl, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl, Juan J. Garcia-Vallejo, Gert Storm, Yvette van Kooyk, Joke M. M. den Haan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Monocytes are antigen-presenting cells (APCs) that play diverse roles in promoting or regulating inflammatory responses, but their role in T cell stimulation is not well defined. In inflammatory conditions, monocytes frequently show increased express
Externí odkaz:
https://doaj.org/article/4b4b49035970432f8d4a489d0e951e6f
Autor:
Matheus H W Crommentuijn, Sjoerd T T Schetters, Laura J W Kruijssen, Yvette van Kooyk, Ernesto Rodriguez, Jan Van den Bossche, Joke M M Den Haan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background PD1 immune checkpoint blockade (αPD1 ICB) has shown unparalleled success in treating many types of cancer. However, response to treatment does not always lead to tumor rejection. While αPD1 ICB relies on cytotoxic CD8+ T cells, antigen-p
Externí odkaz:
https://doaj.org/article/0b3a381377d2418f88931130ae98ba49
Autor:
Martje N. Erkelens, Gera Goverse, Tanja Konijn, Rosalie Molenaar, Marieke R. Beijer, Jan Van den Bossche, Kyra E. de Goede, Sanne G. S. Verberk, Wouter J. de Jonge, Joke M. M. den Haan, Reina E. Mebius
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tissue resident intestinal macrophages are known to exhibit an anti-inflammatory phenotype and produce little pro-inflammatory cytokines upon TLR ligation, allowing symbiotic co-existence with the intestinal microbiota. However, upon acute events suc
Externí odkaz:
https://doaj.org/article/7c1b2ccba2044b309c010d925ddfa5de
Autor:
Maarten K. Nijen Twilhaar, Lucas Czentner, Cornelus F. van Nostrum, Gert Storm, Joke M. M. den Haan
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 954 (2021)
Liposomes have emerged as interesting vehicles in cancer vaccination strategies as their composition enables the inclusion of both hydrophilic and hydrophobic antigens and adjuvants. In addition, liposomes can be decorated with targeting moieties to
Externí odkaz:
https://doaj.org/article/1a7003098fd1408abb345c346e754065
Autor:
Christine W Bruggeman, Julia Houtzager, Barbara Dierdorp, Jesper Kers, Steven T Pals, René Lutter, Thomas van Gulik, Joke M M den Haan, Timo K van den Berg, Robin van Bruggen, Taco W Kuijpers
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223264 (2019)
Recently it was discovered that tissue-resident macrophages derive from embryonic precursors, not only from peripheral blood monocytes, and maintain themselves by self-renewal. Most in-vitro studies on macrophage biology make use of in-vitro cultured
Externí odkaz:
https://doaj.org/article/cf1bab13de7c4340a36d1f723509c4f6