Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors

Autor: Lili Zhu, Krishna Choudhary, Barbara Gonzalez-Teran, Yen-Sin Ang, Reuben Thomas, Nicole R. Stone, Lei Liu, Ping Zhou, Chenchen Zhu, Hongmei Ruan, Yu Huang, Shibo Jin, Angelo Pelonero, Frances Koback, Arun Padmanabhan, Nandhini Sadagopan, Austin Hsu, Mauro W. Costa, Casey A. Gifford, Joke G. van Bemmel, Ruth Hüttenhain, Vasanth Vedantham, Bruce R. Conklin, Brian L. Black, Benoit G. Bruneau, Lars Steinmetz, Nevan J. Krogan, Katherine S. Pollard, Deepak Srivastava

Publikováno v: Circulation. 146(10)

Background: GATA4 (GATA-binding protein 4), a zinc finger–containing, DNA-binding transcription factor, is essential for normal cardiac development and homeostasis in mice and humans, and mutations in this gene have been reported in human heart def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8933c6319a4274c2afbc510fa34f8fe
https://pubmed.ncbi.nlm.nih.gov/35938400

Inversion of a topological domain leads to restricted changes in its gene expression and affects inter-domain communication

Autor: Rafael Galupa, Christel Picard, Nicolas Servant, Elphège P. Nora, Yinxiu Zhan, Joke G. van Bemmel, Fatima El Marjou, Colin Johanneau, Maud Borensztein, Katia Ancelin, Luca Giorgetti, Edith Heard

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), 2022, 149 (9), pp.dev200568. ⟨10.1242/dev.200568⟩

The interplay between the topological organization of the genome and the regulation of gene expression remains unclear. Depletion of molecular factors underlying genome topology, such as CTCF and cohesin, leads to modest alterations in gene expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09a3da8319dd71e4ad86df9cfdcfd35
https://doi.org/10.1101/2022.01.24.477495

Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming

Autor: Reuben Thomas, Karishma Pratt, Kaitlen Samse-Knapp, Lin Ye, Ethan Radzinsky, Joke G. van Bemmel, Nicole Stone, Kathryn N. Ivey, Casey A. Gifford, Amelia Schricker, Tamer M.A. Mohamed, Pengzhi Yu, Deepak Srivastava, Katherine S. Pollard

Publikováno v: Cell stem cell, vol 25, iss 1
Cell Stem Cell
Stone, N R, Gifford, C A, Thomas, R, Pratt, K J B, Samse-Knapp, K, Mohamed, T M A, Radzinsky, E M, Schricker, A, Ye, L, Yu, P, van Bemmel, J G, Ivey, K N, Pollard, K S & Srivastava, D 2019, ' Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming ', Cell Stem Cell, vol. 25, no. 1, pp. 87-102.e9 . https://doi.org/10.1016/j.stem.2019.06.012

Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d33d2776d4d5a4bda36294362c2e3b
https://escholarship.org/uc/item/5063d4vp

Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin

Autor: Sebastian Haase, Danny Nowak, Joke G. van Bemmel, Daniela Meilinger, Jeffrey H. Stear, M. Cristina Cardoso, Henry D. Herce, Heinrich Leonhardt, Corella S. Casas-Delucchi

Publikováno v: Nucleic Acids Research

The replication of the genome is a spatio-temporally highly organized process. Yet, its flexibility throughout development suggests that this process is not genetically regulated. However, the mechanisms and chromatin modifications controlling replic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da24d83f94d27c89d4339110600cfb1
http://europepmc.org/articles/PMC3245938

A Direct Role for Cohesin in Gene Regulation and Ecdysone Response in Drosophila Salivary Glands

Autor: Katsuhiko Shirahige, Takehiko Itoh, Joke G. van Bemmel, Bas van Steensel, Andrea Pauli, Kim Nasmyth, Raquel A. Oliveira

Publikováno v: Current Biology. 20(No. 20):1787-1798

Summary Background Developmental abnormalities observed in Cornelia de Lange syndrome have been genetically linked to mutations in the cohesin machinery. These and other recent experimental findings have led to the suggestion that cohesin, in additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c258e5755c3c54932f512a2d79d5d5
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100747058