Výsledky vyhledávání - "Joke Elskens"

Akademický článek

Synthesis and Improved Cross-Linking Properties of C5-Modified Furan Bearing PNAs

Autor: Joke Elskens, Alex Manicardi, Valentina Costi, Annemieke Madder, Roberto Corradini

Publikováno v: Molecules, Vol 22, Iss 11, p 2010 (2017)

Over the past decades, peptide nucleic acid/DNA (PNA:DNA) duplex stability has been improved via backbone modification, often achieved via introducing an amino acid side chain at the α- or γ-position in the PNA sequence. It was previously shown tha

Externí odkaz: https://doaj.org/article/727195293b644823a466559ed1e7bc54

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Synthesis and structure-activity relationship of peptide nucleic acid probes with improved interstrand-crosslinking abilities: application to biotin-mediated RNA-pulldown

Autor: Enrico Cadoni, Francesca Pennati, Penthip Muangkaew, Joke Elskens, Annemieke Madder, Alex Manicardi

Publikováno v: RSC CHEMICAL BIOLOGY

The development of interstrand-crosslinking (ICL) probes for the covalent targeting of DNA and RNA sequences of interest has been extensively reported in the past decade. However, most of the reactions reported so far induce the formation of a stable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de18933993abf3be9ecea9dd60a95def
https://pubmed.ncbi.nlm.nih.gov/36128507

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Crosslinker-modified nucleic acid probes for improved target identification and biomarker detection

Autor: Annemieke Madder, Joke Elskens

Publikováno v: RSC CHEMICAL BIOLOGY
RSC Chemical Biology

Understanding the intricate interaction pattern of nucleic acids with other molecules is essential to gain further insight in biological processes and disease mechanisms. To this end, a multitude of hybridization-based assays have been designed that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad886f8c15d1abe81d5a8376b9052706
https://biblio.ugent.be/publication/8711240

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Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects

Autor: Joke Elskens, Annemieke Madder, Jan P Elskens

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 4522, p 4522 (2020)
International Journal of Molecular Sciences

Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize analytes with extraordinary target selectivity and affinity. Despite their promising properties and diagnostic potential, the number of commercial applications remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bb6a65bdfbf70820ddd62fddebffee
https://www.mdpi.com/1422-0067/21/12/4522

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Synthesis and Improved Cross-Linking Properties of C5-Modified Furan Bearing PNAs

Autor: Valentina Costi, Annemieke Madder, Roberto Corradini, Alex Manicardi, Joke Elskens

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
MOLECULES
Molecules; Volume 22; Issue 11; Pages: 2010
Molecules, Vol 22, Iss 11, p 2010 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdadfb17f657b7e9750d80229a32c79
http://europepmc.org/articles/PMC6150320

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