Zobrazeno 1 - 10
of 373
pro vyhledávání: '"Joke A, Bouwstra"'
Autor:
Andreea Nădăban, Jannik Rousel, Dounia El Yachioui, Gerrit S. Gooris, Charlotte M. Beddoes, Robert M. Dalgliesh, Marc Malfois, Robert Rissmann, Joke A. Bouwstra
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 8, Pp 100400- (2023)
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main subclasses in the SC lipid matrix are ceramides (CER), cholesterol, and free fatty acids. In inflammatory ski
Externí odkaz:
https://doaj.org/article/76325d43d081451c8bc876cc2b41ec5b
Autor:
Andreea Nădăban, Gerrit S. Gooris, Charlotte M. Beddoes, Robert M. Dalgliesh, Joke A. Bouwstra
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 9, Pp 100258- (2022)
Understanding the lipid arrangement within the skin’s outermost layer, the stratum corneum (SC), is important for advancing knowledge on the skin barrier function. The SC lipid matrix consists of ceramides (CERs), cholesterol, and free fatty acids,
Externí odkaz:
https://doaj.org/article/e8c575f47bec49e5b068ee9d1a0c9322
Autor:
Jeroen van Smeden, Hanin Al-Khakany, Yichen Wang, Dani Visscher, Nicole Stephens, Samira Absalah, Herman S. Overkleeft, Johannes M.F.G. Aerts, Alain Hovnanian, Joke A. Bouwstra
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 859-869 (2020)
Individuals with Netherton syndrome (NTS) have increased serine protease activity, which strongly impacts the barrier function of the skin epidermis and leads to skin inflammation. Here, we investigated how serine protease activity in NTS correlates
Externí odkaz:
https://doaj.org/article/c986b4ebf6c140799096c6d0fac06e3a
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2329-2338 (2018)
The lipid matrix of the stratum corneum, the outermost skin layer, consists primarily of ceramides, cholesterol, and FFAs. These lipids form a trilayer long-periodicity phase (LPP) that is unique to this barrier. Knowledge about the LPP is essential
Externí odkaz:
https://doaj.org/article/fc00215286304b268215e274d91fb6fb
Autor:
Walter A. Boiten, Tineke Berkers, Samira Absalah, Jeroen van Smeden, Adriana P.M. Lavrijsen, Joke A. Bouwstra
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 250-260 (2018)
Restoring the lipid homeostasis of the stratum corneum (SC) is a common strategy to enhance skin barrier function. Here, we used a ceramide containing vernix caseosa (VC)-based formulation and were able to accelerate barrier recovery in healthy volun
Externí odkaz:
https://doaj.org/article/6c59326f1a8344cca1c831d859f293bd
Publikováno v:
Acta Dermato-Venereologica, Vol 98, Iss 4, Pp 421-427 (2018)
Previously, a skin barrier repair model was developed to examine the effect of formulations on the lipid properties of compromised skin. In this model, the lipid organization mimics that of several skin diseases with impaired skin barrier and less de
Externí odkaz:
https://doaj.org/article/0d7040042a994993b296c01a690d2e11
Autor:
Jeroen van Smeden, Irini M. Dijkhoff, Richard W.J. Helder, Hanin Al-Khakany, Daphne E.C. Boer, Anne Schreuder, Wouter W. Kallemeijn, Samira Absalah, Herman S. Overkleeft, Johannes M.F.G. Aerts, Joke A. Bouwstra
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 12, Pp 2299-2309 (2017)
Epidermal β-glucocerebrosidase (GBA1), an acid β-glucosidase normally located in lysosomes, converts (glucosyl)ceramides into ceramides, which is crucial to generate an optimal barrier function of the outermost skin layer, the stratum corneum (SC).
Externí odkaz:
https://doaj.org/article/00a799f942364befb5381154410a58c9
Autor:
Richard W. J. Helder, Jannik Rousel, Walter A. Boiten, Gerrit S. Gooris, Andreea Nadaban, Abdoelwaheb El Ghalbzouri, Joke A. Bouwstra
Publikováno v:
Experimental Dermatology, 32(4), 469-478. WILEY
Helder, R W J, Rousel, J, Boiten, W A, Gooris, G S, Nadaban, A, el Ghalbzouri, A & Bouwstra, J A 2022, ' The effect of PPAR isoform (de)activation on the lipid composition in full-thickness skin models ', Experimental Dermatology . https://doi.org/10.1111/exd.14733
Experimental Dermatology. Wiley-Blackwell
Helder, R W J, Rousel, J, Boiten, W A, Gooris, G S, Nadaban, A, el Ghalbzouri, A & Bouwstra, J A 2022, ' The effect of PPAR isoform (de)activation on the lipid composition in full-thickness skin models ', Experimental Dermatology . https://doi.org/10.1111/exd.14733
Experimental Dermatology. Wiley-Blackwell
Human skin equivalents (HSEs) are 3D-cultured human skin models that mimic many aspects of native human skin (NHS). Although HSEs resemble NHS very closely, the barrier located in the stratum corneum (SC) is impaired. This is caused by an altered lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072fa43d1edd9e9b91fef8a853195e42
http://hdl.handle.net/1887/3514831
http://hdl.handle.net/1887/3514831
Publikováno v:
Langmuir
Langmuir, 37(31), 9478-9489
Langmuir, 37(31), 9478-9489
The skin barrier function is attributed to the stratum corneum (SC) intercellular lipid matrix, which is composed primarily of ceramides (CERs), free fatty acids, and cholesterol. These lipids are organized in two lamellar phases: the short and long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20567c9846df1724eec11b27265db0a1
https://doi.org/10.1021/acs.langmuir.1c01295
https://doi.org/10.1021/acs.langmuir.1c01295
Autor:
Arnout Mieremet, Marion Rietveld, Samira Absalah, Jeroen van Smeden, Joke A Bouwstra, Abdoelwaheb El Ghalbzouri
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174478 (2017)
Full thickness human skin models (FTMs) contain an epidermal and a dermal equivalent. The latter is composed of a collagen dermal matrix which harbours fibroblasts. Current epidermal barrier properties of FTMs do not fully resemble that of native hum
Externí odkaz:
https://doaj.org/article/aaec29a12229459fadd60c645c1d29b1