Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joi Dunbar"'
Autor:
George D. Demetri, David Grayzel, Emmanuel Normant, Joi Dunbar, Michael Gordon, Suzanne George, Jeffrey A. Morgan, Lee S. Rosen, Rashmi Chugh, Andrew J. Wagner
Supplementary Figure 2 - PDF file 49K, Example Western Blot Showing that IPI 504 above 150 mg/m2 Induces an Increase in Hsp70 in PBLs from GIST Patients PBLs were purified from GIST patient samples, and lysed. Ten microg of protein lysates were run o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb57d0feed36c013d4c97c1a10f7420
https://doi.org/10.1158/1078-0432.22449947.v1
https://doi.org/10.1158/1078-0432.22449947.v1
Autor:
George D. Demetri, David Grayzel, Emmanuel Normant, Joi Dunbar, Michael Gordon, Suzanne George, Jeffrey A. Morgan, Lee S. Rosen, Rashmi Chugh, Andrew J. Wagner
Supplementary Table 1 - PDF file 74K, Mean (SD) pharmacokinetic parameters of IPI-504 and metabolites on Cycle 1, Day 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dbad7695bec95e9a2a536bccd44fa7
https://doi.org/10.1158/1078-0432.22449941
https://doi.org/10.1158/1078-0432.22449941
Autor:
George D. Demetri, David Grayzel, Emmanuel Normant, Joi Dunbar, Michael Gordon, Suzanne George, Jeffrey A. Morgan, Lee S. Rosen, Rashmi Chugh, Andrew J. Wagner
Supplementary Figure Legend - PDF file 74K, Supplementary figure legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1af4e1f0cb128c4c0cfca214c22a6d
https://doi.org/10.1158/1078-0432.22449944
https://doi.org/10.1158/1078-0432.22449944
Autor:
George D. Demetri, David Grayzel, Emmanuel Normant, Joi Dunbar, Michael Gordon, Suzanne George, Jeffrey A. Morgan, Lee S. Rosen, Rashmi Chugh, Andrew J. Wagner
Supplementary Figure 1 - PDF file173K, Mean (plus-minus SD) Plasma Concentrations of IPI-504, 17-AAG and 17-AG following a Single Dose of IPI-504 400 mg/m2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a7f484505d3cb731da6e499bda314b
https://doi.org/10.1158/1078-0432.22449950.v1
https://doi.org/10.1158/1078-0432.22449950.v1
Autor:
George D. Demetri, David Grayzel, Emmanuel Normant, Joi Dunbar, Michael Gordon, Suzanne George, Jeffrey A. Morgan, Lee S. Rosen, Rashmi Chugh, Andrew J. Wagner
Purpose: Heat shock protein 90 (HSP90) is required for the proper folding, function, and stability of various client proteins, two of which (KIT and PDGFRα) are critical in the pathogenesis and progression of gastrointestinal stromal tumors (GIST).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4568bbb33e9930ba5b60a039ed2731ca
https://doi.org/10.1158/1078-0432.c.6521804
https://doi.org/10.1158/1078-0432.c.6521804
Autor:
Joi Dunbar, Simon Tate, Beth Tidemann-Miller, Mark Versavel, Himanshu Naik, Joanne Palmer, Valerie Morisset, Yuan Zhao, Gerard M. P. Giblin
Publikováno v:
Clinical pharmacology in drug developmentReferences. 9(1)
Vixotrigine is a voltage- and use-dependent Nav1.7 channel blocker under investigation for the treatment of peripheral neuropathic pain conditions, including trigeminal neuralgia. Vixotrigine is metabolized primarily via uridine diphosphate-glucurono
Autor:
Alice R. Lim, Pingda Ren, Yi Liu, Jonathan P. DiNitto, Christian C. Fritz, Katti Jessen, Erin Murphy, Vito J. Palombella, Jennifer Lussier, Janid A. Ali, Brian D. Thomas, Kerry White, Lian-Sheng Li, Paul S. Changelian, Melissa Pink, Joi Dunbar, Jennifer Hoyt, Erin Brophy, Bonnie Tillotson, James R. Porter, John Macdougall, David G. Winkler, Christian Rommel, Kerrie Faia, Christian M. Martin, Jennifer L. Proctor, Jeffery L. Kutok
Publikováno v:
Chemistry & Biology. 20:1364-1374
SummaryPhosphoinositide-3 kinase (PI3K)-δ and PI3K-γ are preferentially expressed in immune cells, and inhibitors targeting these isoforms are hypothesized to have anti-inflammatory activity by affecting the adaptive and innate immune response. We
Autor:
George D. Demetri, Jeffrey A. Morgan, Andrew J. Wagner, Joi Dunbar, David Grayzel, Emmanuel Normant, Suzanne George, Lee S. Rosen, Michael S. Gordon, Rashmi Chugh
Publikováno v:
Clinical Cancer Research. 19:6020-6029
Purpose: Heat shock protein 90 (HSP90) is required for the proper folding, function, and stability of various client proteins, two of which (KIT and PDGFRα) are critical in the pathogenesis and progression of gastrointestinal stromal tumors (GIST).
Autor:
Joi Dunbar, Margaret A. Read, Joseph D. Manna, Alexander Constan, Alfredo C. Castro, Sherri Smith, Gordon Loewen, John Lee, Somarajan J. Nair, Jennifer Hoyt, Martin R. Tremblay, Julian Adams, Jeanne A. Ferguson, Jens Sydor, Veronica Campbell, Matthew Campbell, Karen McGovern, Brendan Arsenault, Marisa O. Peluso, Jylle Nevejans, Vito J. Palombella, Nigel Whitebread, Grogan Michael John, Kerrie Faia, John Soglia, Bennett Carter
Publikováno v:
Xenobiotica. 43:875-885
1. IPI-926 is a novel semisynthetic cyclopamine derivative that is a potent and selective Smoothened inhibitor that blocks the hedgehog signal transduction pathway. 2. The in vivo clearance of IPI-926 is low in mouse and dog and moderate in monkey. T
Autor:
Glenn J. Bubley, William Oh, Robert W. Ross, J. Goddard, Matthew D. Galsky, Walter M. Stadler, Joi Dunbar, Sandy Srinivas, Franklin Chu
Publikováno v:
Urology. 78:626-630
Objective To evaluate clinical activity and safety of retaspimycin hydrochloride (IPI-504) in patients with castration-resistant prostate cancer (CRPC). Methods A single-arm trial was conducted in 2 cohorts: group 1, chemotherapy naive; group 2, doce