Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Johnvesly Basappa"'
Autor:
Kavindra Nath, Pradeep K. Gupta, Johnvesly Basappa, Shengchun Wang, Neil Sen, Cosimo Lobello, Jyoti S. Tomar, Alexander A. Shestov, Stepan Orlovskiy, Fernando Arias-Mendoza, Hilka Rauert-Wunderlich, David S. Nelson, Jerry D. Glickson, Mariusz A. Wasik
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Inhibition of kinases is the ever-expanding therapeutic approach to various types of cancer. Typically, assessment of the treatment response is accomplished by standard, volumetric imaging procedures, performed weeks to months aft
Externí odkaz:
https://doaj.org/article/0e7806c50fd74e3da89b30454ab92a58
Autor:
Johnvesly Basappa, Mevlut Citir, Qian Zhang, Hong Y. Wang, Xiaobin Liu, Olga Melnikov, Hafiz Yahya, Frank Stein, Rainer Muller, Alexis Traynor-Kaplan, Carsten Schultz, Mariusz A. Wasik, Andrzej Ptasznik
Publikováno v:
Heliyon, Vol 6, Iss 5, Pp e03910- (2020)
A fundamental feature of tumor progression is reprogramming of metabolic pathways. ATP citrate lyase (ACLY) is a key metabolic enzyme that catalyzes the generation of Acetyl-CoA and is upregulated in cancer cells and required for their growth. The ph
Externí odkaz:
https://doaj.org/article/a6299949ea754bc2954c360ced29c4b7
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 2, Pp 246-258 (2010)
Noise-induced hearing loss is a highly prevalent occupational injury, yet little is known concerning the signals controlling normal cochlear sensitivity and susceptibility to noise-induced trauma. While the corticotropin-releasing factor (CRF) system
Externí odkaz:
https://doaj.org/article/c3bc0d4be8034c0d90cfe2a8a89fef86
Autor:
Qian Zhang, Hong Y. Wang, Anindita Nayak, Selene Nunez-Cruz, Artur Slupianek, Xiaobin Liu, Johnvesly Basappa, Jing-Song Fan, Seble Chekol, Reza Nejati, Agata M. Bogusz, Suzanne D. Turner, Kunchithapadam Swaminathan, Mariusz A. Wasik
Publikováno v:
The American Journal of Pathology. 192:1186-1198
This study reports that hairy and enhancer of split homolog-1 (HES1), known to repress gene transcription in progenitor cells of several cell lineages, was strongly expressed in cells and tissues of T-cell lymphoma expressing the oncogenic chimeric t
Autor:
Jonathan H. Schatz, Mahmoud El-Azzouny, Charles F. Burant, Amit Dipak Amin, Nathanael G. Bailey, Gleb A. Bazilevsky, John K. Frederiksen, Santiago Schnell, Kaiyu Ma, James L. Riley, Megan S. Lim, Johnvesly Basappa, Yeqiao Zhou, Steven R. Hwang, Anagh A. Sahasrabuddhe, Kathryn E. Wellen, Kevin P. Conlon, Kojo S.J. Elenitoba-Johnson, Robert B. Faryabi, Venkatesha Basrur, Ronen Marmorstein, Jan M. Pawlicki, David L. Cookmeyer, Delphine Rolland
A fundamental requirement for growth of rapidly proliferating cells is metabolic adaptation to promote synthesis of biomass1. ATP citrate lyase (ACLY) is a critical enzyme responsible for synthesis of cytosolic acetyl-CoA, the key building component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed542fe418b17ad5f4209e1c1fe96cc8
https://doi.org/10.1101/2020.01.20.910752
https://doi.org/10.1101/2020.01.20.910752
Autor:
Olga Melnikov, Frank Stein, Mevlut Citir, Johnvesly Basappa, Hong Y. Wang, Andrzej Ptasznik, Carsten Schultz, Qian Zhang, Rainer Müller, Mariusz A. Wasik, Hafiz Yahya, Xiaobin Liu, Alexis Traynor-Kaplan
Publikováno v:
SSRN Electronic Journal.
ATP citrate lyase (ACLY) is a key metabolic enzyme that catalyzes the generation of Acetyl-CoA and is upregulated in cancer cells and required for their growth. The phosphoinositide 3-kinase (PI3K) and Src-family kinase (SFK) Lyn are constitutively a
Autor:
Ke Liu, Elizabeth A. Whitcomb, Johnvesly Basappa, Aurélie K Le Feuvre, Yien Che Tsai, Allan M Weissman, Allen Taylor
Publikováno v:
The FASEB Journal. 33:1235-1247
Ubiquitinylation drives many cellular processes by targeting proteins for proteasomal degradation. Ubiquitin conjugation enzymes promote ubiquitinylation and, thus, degradation of protein substrates. Ubiquitinylation is a well-known posttranslational
Autor:
Venkatesha Basrur, Megan S. Lim, Noah A. Brown, Johnvesly Basappa, Kojo S.J. Elenitoba-Johnson, Veronica Mendoza-Reinoso, Ryan A. Wilcox, Scott Rp McDonnell, Carlos Murga-Zamalloa, Steven R. Hwang
Publikováno v:
Laboratory Investigation. 97:962-970
PKM2 (pyruvate kinase M2), a critical regulator of glycolysis, is phosphorylated by numerous growth factor receptors and oncogenic tyrosine kinases including NPM-ALK which is expressed in a subset of aggressive T-cell non-Hodgkin lymphomas known as a
Autor:
Olga Melnikov, Hong Y. Wang, Andrzej Ptasznik, Qian Zhang, Mevlut Citir, Frank Stein, Hafiz Yahya, Xiaobin Liu, Rainer Müller, Carsten Schultz, Mariusz A. Wasik, Alexis Traynor-Kaplan, Johnvesly Basappa
Publikováno v:
Heliyon, Vol 6, Iss 5, Pp e03910-(2020)
A fundamental feature of tumor progression is reprogramming of metabolic pathways. ATP citrate lyase (ACLY) is a key metabolic enzyme that catalyzes the generation of Acetyl-CoA and is upregulated in cancer cells and required for their growth. The ph
Autor:
Douglas E, Vetter, Johnvesly, Basappa
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1427
Modern biologists have at their disposal a large array of techniques used to assess the existence and relative or absolute quantity of any molecule of interest in a sample. However, implementing most of these procedures can be a daunting task for the