Characterization and validation of a preventative therapy for hypertrophic cardiomyopathy in a murine model of the disease.

Autor: Viola HM; School of Human Sciences (Physiology), The University of Western Australia, Crawley, WA 6009, Australia; helena.viola@uwa.edu.au livia.hool@uwa.edu.au., Shah AA; School of Human Sciences (Physiology), The University of Western Australia, Crawley, WA 6009, Australia., Johnstone VPA; School of Human Sciences (Physiology), The University of Western Australia, Crawley, WA 6009, Australia., Cserne Szappanos H; School of Human Sciences (Physiology), The University of Western Australia, Crawley, WA 6009, Australia., Hodson MP; Victor Chang Innovation Centre, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.; School of Pharmacy, University of Queensland, Woolloongabba, QLD 4072, Australia., Hool LC; School of Human Sciences (Physiology), The University of Western Australia, Crawley, WA 6009, Australia; helena.viola@uwa.edu.au livia.hool@uwa.edu.au.; Victor Chang Innovation Centre, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 15; Vol. 117 (37), pp. 23113-23124. Date of Electronic Publication: 2020 Aug 28.

Adult-onset obesity is triggered by impaired mitochondrial gene expression.

Autor: Perks KL; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia 6009, Australia., Ferreira N; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia 6009, Australia., Richman TR; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia 6009, Australia., Ermer JA; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia 6009, Australia., Kuznetsova I; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia 6009, Australia., Shearwood AJ; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia 6009, Australia., Lee RG; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia 6009, Australia., Viola HM; School of Human Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia., Johnstone VPA; School of Human Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia., Matthews V; School of Biomedical Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia., Hool LC; School of Human Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia.; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia., Rackham O; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia 6009, Australia.; School of Molecular Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia., Filipovska A; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia 6009, Australia.; School of Molecular Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia.

Publikováno v: Science advances [Sci Adv] 2017 Aug 16; Vol. 3 (8), pp. e1700677. Date of Electronic Publication: 2017 Aug 16 (Print Publication: 2017).

The Role of the L-Type Ca ²⁺ Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy.

Autor: Viola HM; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Australia., Johnstone VPA; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Australia., Cserne Szappanos H; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Australia., Richman TR; The Harry Perkins Institute for Medical Research, The University of Western Australia, Crawley, Australia., Tsoutsman T; Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Sydney, Australia.; Sydney Medical School, University of Sydney, Australia., Filipovska A; The Harry Perkins Institute for Medical Research, The University of Western Australia, Crawley, Australia., Semsarian C; Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Sydney, Australia.; Sydney Medical School, University of Sydney, Australia.; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia., Seidman JG; Harvard Medical School, Harvard University, Boston, Massachusetts., Seidman CE; Harvard Medical School, Harvard University, Boston, Massachusetts., Hool LC; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Australia.; Victor Chang Cardiac Research Institute, Sydney, Australia.

Publikováno v: JACC. Basic to translational science [JACC Basic Transl Sci] 2016 Feb 13; Vol. 1 (1-2), pp. 61-72. Date of Electronic Publication: 2016 Feb 13 (Print Publication: 2016).