Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Johnstone MA"'
Autor:
Silvia N Kariuki, Alexander W Macharia, Johnstone Makale, Wilfred Nyamu, Stephen L Hoffman, Melissa C Kapulu, Philip Bejon, Julian C Rayner, Thomas N Williams, On behalf of for the CHMI-SIKA Study Team
Publikováno v:
eLife, Vol 12 (2023)
Background: The long co-evolution of Homo sapiens and Plasmodium falciparum has resulted in the selection of numerous human genetic variants that confer an advantage against severe malaria and death. One such variant is the Dantu blood group antigen,
Externí odkaz:
https://doaj.org/article/d7bea6c1ed454a08936dbbdec5422d73
Autor:
Albert Koulman, Kelsey Jones, James Berkley, Judd Walson, Eric Houpt, David S. Wishart, Christina L. Lancioni, Moses Ngari, Lei Xia, James M. Njunge, Abdoulaye Hama Diallo, Kirkby Tickell, Md. Amran Gazi, Abu Sadat Mohammad Sayeem Bin Shahid, Zaubina Kazi, Ali Saleem, Caroline Tigoi, Syed Ali, Emily Yoshioka, Ezekiel Mupere, Moses Mburu, Mohammod Jobayer Chisti, Bonface Gichuki, Narshion Ngao, Wilson Gumbi, Elisha Omer, Robert Bandsma, Benson Singa, Wieger Voskuijl, Tahmeed Ahmed, Alex Macharia, Thomas N. Williams, Anna Mitchel, Johnstone Makale, Joe Gogain, Jessica Williams, Rupasri Mandal, Nebojsa Janjic, Michael Routledge, Hang Wu, Camilo Espinosa, Yun Yun Gong, Jie Liu, Nima Aghaeepour, Hilary Browne, Trevor D. Lawley, Doreen Rwigi, Yan Shao, Timothy Kaburu, Kevin Kariuki, Lisa Gartner, Holm H. Uhlig
Publikováno v:
Gates Open Research, Vol 6 (2022)
Introduction: Many acutely ill children in low- and middle-income settings have a high risk of mortality both during and after hospitalisation despite guideline-based care. Understanding the biological mechanisms underpinning mortality may suggest op
Externí odkaz:
https://doaj.org/article/4f784e51afb14738813820fdbf1f5a7d
Autor:
Neema Mturi, Alexander W. Macharia, George Mochamah, Anna Färnert, Thad Howard, Thomas N. Williams, Russell E. Ware, Johnstone Makale, Peter Olupot-Olupot
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Background: β-thalassemia is rare in sub-Saharan Africa and to our knowledge there has been no case of homozygous β-thalassemia major reported from this region. In a recent cohort study, we identified four β-thalassemia mutations among 83 heterozy
Externí odkaz:
https://doaj.org/article/31bd5b0570a4450ab3b87999f253527b
Autor:
Stella Kiambi, Eric M. Fèvre, Pablo Alarcon, Nduhiu Gitahi, Johnstone Masinde, Erastus Kang'ethe, Gabriel Aboge, Jonathan Rushton, Joshua Orungo Onono
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Food networks present varying food safety concerns because of the complexity of interactions, production, and handling practices. We investigated total bacteria counts (TBCs) and total coliform counts (TCCs) in various nodes of a Nairobi dairy value
Externí odkaz:
https://doaj.org/article/e5173eb29f21495e92b239a7b66fe33f
Autor:
Hannah W. Kimingi, Ann W. Kinyua, Nicole A. Achieng, Kennedy M. Wambui, Shaban Mwangi, Roselyne Nguti, Cheryl A. Kivisi, Anja T. R. Jensen, Philip Bejon, Melisa C. Kapulu, Abdirahman I. Abdi, Samson M. Kinyanjui, CHMI-SIKA Study Team, Abdirahman I Abdi, Yonas Abebe, Agnes Audi, Peter Billingsley, Peter C Bull, Primus Che, Zaydah de Laurent, Susanne H Hodgson, Stephen Hoffman, Eric James, Irene Jao, Dorcas Kamuya, Gathoni Kamuyu, Silvia Kariuki, Nelson Kibinge, Sam Kinyanjui, Cheryl Kivisi, Nelly Koskei, Mallika Imwong, Brett Lowe, Johnstone Makale, Kevin Marsh, Vicki Marsh, Khadija Said Mohammed, Moses Mosobo, Sean C Murphy, Jennifer Musyoki, Michelle Muthui, Jedidah Mwacharo, Daniel Mwanga, Joyce Mwongeli, Francis Ndungu, Maureen Njue, George Nyangweso, Domitila Kimani, Joyce M. Ngoi, Janet Musembi, Omar Ngoto, Edward Otieno, Bernhards Ogutu, Fredrick Olewe, James Oloo, Donwilliams Omuoyo, John Ongecha, Martin O Ongas, Michael Ooko, Jimmy Shangala, Betty Kim Lee Sim, Joel Tarning, Juliana Wambua, Thomas N Williams, Markus Winterberg
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundPlasmodium falciparum variant surface antigens (VSAs) contribute to malaria pathogenesis by mediating cytoadhesion of infected red blood cells to the microvasculature endothelium. In this study, we investigated the association between anti-
Externí odkaz:
https://doaj.org/article/330b0f288975431b9dc0453fdfdfcfe9
Autor:
Shadrack Mutua, Brian Bartilol, Shaban J. Mwangi, Debra Riako, Lydia Nyamako, Bonface M. Gichuki, Henry Karanja, Angela Karani, John N. Gitonga, Daisy Mugo, Brian Tawa, Wilson Gumbi, Wesley Cheruiyot, Metrine Tendwa, John K. Nyambu, Yiakon Sein, Thani Suleiman Thani, Shem O. Patta, Benson Kitole, Eric K. Maitha, Barke S. Muslih, Mohamed S. Mwakinangu, Philip Bejon, Benjamin Tsofa, Joyce U. Nyiro, John Ochieng Otieno, Leonard Ndwiga, Patience Kiyuka, Johnstone Makale, Kevin Wamae, Victor Osoti, John Mwita Morobe, Calleb Odundo, Arnold W. Lambisia, Martin Mutunga, Salim Mwarumba, Lynette Isabella Ochola-Oyier, Charles N. Agoti, Clement Lewa, Elijah Gicheru, Jennifer Musyoki, Susan Njuguna, Horace Gumba, Domtila Kimani, Jedidah Mwacharo, Zaydah R. de Laurent, Khadija Said Mohammed, Robinson Cheruiyot, Donwilliams O. Omuoyo
Publikováno v:
Wellcome Open Research, Vol 5 (2022)
Background: The COVID-19 pandemic relies on real-time polymerase chain reaction (qRT-PCR) for the detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), to facilitate roll-out of patient care and infection control measures. There
Externí odkaz:
https://doaj.org/article/7bfed2fab94a4894a12683a69695a1a8
Autor:
Shadrack Mutua, Brian Bartilol, Debra Riako, Lydia Nyamako, Angela Karani, Daisy Mugo, Brian Tawa, Michael Opiyo, Wesley Cheruiyot, Metrine Tendwa, Oscar Kai, Caroline Ngetsa, Yiakon Sein, Nelson Ouma, Arnold W. Lambisia, Bonface M. Gichuki, Boniface Karia, John M. Morobe, Shaban Mwangi, Benjamin Tsofa, Philip Bejon, Alfred Mwakubia, Fredrick Mitsanze, Kelly Ominde, Patience Kiyuka, Martin Rono, Johnstone Makale, Agnes Mutiso, Perpetual Wanjiku, Victor Osoti, John N. Gitonga, Alfred Mwanzu, Calleb Odundo, Martin Mutunga, Salim Mwarumba, Donwilliams O. Omuoyo, Amek Nyaguara, Clement Lewa, Elijah Gicheru, Wilson Gumbi, Jennifer Musyoki, Susan Njuguna, Moses Mosobo, Lynette Isabella Ochola-Oyier, Horace Gumba, Wilfred Nyamu, Khadija Said Mohammed, Janet Thoya, Edward Otieno, Domtila Kimani, Jedidah Mwacharo, David Amadi, Charles N. Agoti, Zaydah R. de Laurent, Robinson Cheruiyot
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
Laboratory diagnosis plays a critical role in the containment of a pandemic. Strong laboratory quality management systems (QMS) are essential for laboratory diagnostic services. However, low laboratory capacities in resource-limited countries has mad
Externí odkaz:
https://doaj.org/article/38df41bcb17d48b499049a7e92746f40
Autor:
Kelvin M. Abuga, John Muthii Muriuki, Sophie M. Uyoga, Kennedy Mwai, Johnstone Makale, Reagan M. Mogire, Alex W. Macharia, Shebe Mohammed, Esther Muthumbi, Salim Mwarumba, Neema Mturi, Philip Bejon, J. Anthony G. Scott, Manfred Nairz, Thomas N. Williams, Sarah H. Atkinson
Publikováno v:
Haematologica, Vol 107, Iss 7 (2021)
Malaria and invasive non-typhoidal Salmonella (NTS) are life-threatening infections that often co-exist in African children. The iron-regulatory hormone hepcidin is highly upregulated during malaria and controls the availability of iron, a critical n
Externí odkaz:
https://doaj.org/article/5f273c88ed874845bcbc4abc14da9594
Autor:
Charles N. Agoti, Martin Mutunga, Arnold W. Lambisia, Domtila Kimani, Robinson Cheruiyot, Patience Kiyuka, Clement Lewa, Elijah Gicheru, Metrine Tendwa, Khadija Said Mohammed, Victor Osoti, Johnstone Makale, Brian Tawa, Calleb Odundo, Wesley Cheruiyot, Wilfred Nyamu, Wilson Gumbi, Jedidah Mwacharo, Lydia Nyamako, Edward Otieno, David Amadi, Janet Thoya, Angela Karani, Daisy Mugo, Jennifer Musyoki, Horace Gumba, Salim Mwarumba, Bonface M. Gichuki, Susan Njuguna, Debra Riako, Shadrack Mutua, John N. Gitonga, Yiakon Sein, Brian Bartilol, Shaban J. Mwangi, Donwilliams O. Omuoyo, John M. Morobe, Zaydah R. de Laurent, Philip Bejon, Lynette Isabella Ochola-Oyier, Benjamin Tsofa
Publikováno v:
Wellcome Open Research, Vol 5 (2021)
Background. International recommendations for the control of the coronavirus disease 2019 (COVID-19) pandemic emphasize the central role of laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent, at
Externí odkaz:
https://doaj.org/article/cc75d2b49c494934bd157ea4993d07d1
Autor:
Charles N. Agoti, Martin Mutunga, Arnold W. Lambisia, Domtila Kimani, Robinson Cheruiyot, Patience Kiyuka, Clement Lewa, Elijah Gicheru, Metrine Tendwa, Khadija Said Mohammed, Victor Osoti, Johnstone Makale, Brian Tawa, Calleb Odundo, Wesley Cheruiyot, Wilfred Nyamu, Wilson Gumbi, Jedidah Mwacharo, Lydia Nyamako, Edward Otieno, David Amadi, Janet Thoya, Angela Karani, Daisy Mugo, Jennifer Musyoki, Horace Gumba, Salim Mwarumba, Bonface M. Gichuki, Susan Njuguna, Debra Riako, Shadrack Mutua, John N. Gitonga, Yiakon Sein, Brian Bartilol, Shaban J. Mwangi, Donwilliams O. Omuoyo, John M. Morobe, Zaydah R. de Laurent, Philip Bejon, Lynette Isabella Ochola-Oyier, Benjamin Tsofa
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Background. International recommendations for the control of the coronavirus disease 2019 (COVID-19) pandemic emphasize the central role of laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent, at
Externí odkaz:
https://doaj.org/article/c81e844a41e74de0a9a1eaf25961e746