Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer.

Autor: Koo J; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia., Seong CS; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia., Parker RE; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia.; Cancer Biology Graduate Program, Emory University, Atlanta, Georgia., Herrera A; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia., Dwivedi B; Biostatistics and Bioinformatics Shared Resource, Winship Cancer Institute of Emory University, Atlanta, Georgia., Arthur RA; Emory Integrated Computational Core, Emory University School of Medicine, Atlanta, Georgia., Dinasarapu AR; Department of Neurology, Emory University School of Medicine, Atlanta, Georgia., Johnston HR; Emory Integrated Computational Core, Emory University School of Medicine, Atlanta, Georgia., Claussen H; Emory Integrated Computational Core, Emory University School of Medicine, Atlanta, Georgia., Tucker-Burden C; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia., Ramalingam SS; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia., Fu H; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia.; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia., Zhou W; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia., Marcus AI; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia., Gilbert-Ross M; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia.

Publikováno v: Cancer research [Cancer Res] 2024 Nov 15; Vol. 84 (22), pp. 3761-3771.

The frequency and function of nucleoprotein-specific CD8 ⁺ T cells are critical for heterosubtypic immunity against influenza virus infection.

Autor: Amoah S; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Cao W; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Sayedahmed EE; Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, USA., Wang Y; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Kumar A; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Mishina M; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Eddins DJ; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Wang W-C; Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, USA., Burroughs M; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Sheth M; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Lee J; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Shieh W-J; Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Ray SD; Department of Biology, Georgia State University, Atlanta, Georgia, USA., Bohannon CD; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Ranjan P; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Sharma SD; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Hoehner J; Emory Integrated Computational Core, Emory Integrated Core Facilities, Emory University, Atlanta, Georgia, USA., Arthur RA; Emory Integrated Computational Core, Emory Integrated Core Facilities, Emory University, Atlanta, Georgia, USA., Gangappa S; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Wakamatsu N; Indiana Animal Disease Diagnostic Laboratory, Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, USA., Johnston HR; Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia, USA., Pohl J; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Mittal SK; Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, USA., Sambhara S; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Publikováno v: Journal of virology [J Virol] 2024 Aug 20; Vol. 98 (8), pp. e0071124. Date of Electronic Publication: 2024 Jul 31.

Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS.

Autor: Zhao Y; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA., Wang Y; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA., Shi L; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA., McDonald-McGinn DM; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA., Crowley TB; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA., McGinn DE; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA., Tran OT; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA., Miller D; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA., Lin JR; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA., Zackai E; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA., Johnston HR; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA., Chow EWC; Department of Psychiatry, University of Toronto, Ontario, M5G 0A4, Canada., Vorstman JAS; Program in Genetics and Genome Biology, Research Institute and Autism Research Unit, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Vingerhoets C; Department of Psychiatry and Psychology, Maastricht University, Maastricht, 6200, MD, the Netherlands., van Amelsvoort T; Department of Psychiatry and Psychology, Maastricht University, Maastricht, 6200, MD, the Netherlands., Gothelf D; The Division of Child & Adolescent Psychiatry, Edmond and Lily Sapfra Children's Hospital, Sheba Medical Center and Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Ramat Gan, 5262000, Israel., Swillen A; Center for Human Genetics, University Hospital Leuven, Department of Human Genetics, University of Leuven (KU Leuven), Leuven, 3000, Belgium., Breckpot J; Center for Human Genetics, University Hospital Leuven, Department of Human Genetics, University of Leuven (KU Leuven), Leuven, 3000, Belgium., Vermeesch JR; Center for Human Genetics, University Hospital Leuven, Department of Human Genetics, University of Leuven (KU Leuven), Leuven, 3000, Belgium., Eliez S; Developmental Imaging and Psychopathology Laboratory, Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, 1211, Switzerland., Schneider M; Developmental Imaging and Psychopathology Laboratory, Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, 1211, Switzerland., van den Bree MBM; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Wales, CF24 4HQ, UK., Owen MJ; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Wales, CF24 4HQ, UK., Kates WR; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, 13202, USA.; Program in Neuroscience, SUNY Upstate Medical University, Syracuse, NY, 13202, USA., Repetto GM; Center for Genetics and Genomics, Facultad de Medicina Clinica Alemana-Universidad del Desarrollo, Santiago, 7710162, Chile., Shashi V; Department of Pediatrics, Duke University, Durham, NC, 27710, USA., Schoch K; Department of Pediatrics, Duke University, Durham, NC, 27710, USA., Bearden CE; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA, 90095, USA., Digilio MC; Department of Medical Genetics, Bambino Gesù Hospital, Rome, 00165, Italy., Unolt M; Department of Medical Genetics, Bambino Gesù Hospital, Rome, 00165, Italy.; Department of Pediatrics, Gynecology, and Obstetrics, La Sapienza University of Rome, Rome, 00185, Italy., Putotto C; Department of Pediatrics, Gynecology, and Obstetrics, La Sapienza University of Rome, Rome, 00185, Italy., Marino B; Department of Pediatrics, Gynecology, and Obstetrics, La Sapienza University of Rome, Rome, 00185, Italy., Pontillo M; Department of Neuroscience, Bambino Gesù Hospital, Rome, 00165, Italy., Armando M; Department of Neuroscience, Bambino Gesù Hospital, Rome, 00165, Italy.; Developmental Imaging and Psychopathology Lab, University of Geneva, Geneva, 1211, Switzerland., Vicari S; Department of Life Sciences and Public Health, Catholic University and Child & Adolescent Psychiatry Unit at Bambino Gesù Hospital, Rome, 00165, Italy., Angkustsiri K; Developmental Behavioral Pediatrics, MIND Institute, University of California, Davis, CA, 95817, USA., Campbell L; School of Psychology, University of Newcastle, Newcastle, 2258, Australia., Busa T; Department of Medical Genetics, Aix-Marseille University, Marseille, 13284, France., Heine-Suñer D; Genomics of Health and Unit of Molecular Diagnosis and Clinical Genetics, Son Espases University Hospital, Balearic Islands Health Research Institute, Palma de Mallorca, 07120, Spain., Murphy KC; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, 505095, Ireland., Murphy D; Department of Forensic and Neurodevelopmental Sciences, King's College London, Institute of Psychiatry, Psychology, and Neuroscience, London, SE5 8AF, UK.; Behavioral and Developmental Psychiatry Clinical Academic Group, Behavioral Genetics Clinic, National Adult Autism and ADHD Service, South London and Maudsley Foundation National Health Service Trust, London, SE5 8AZ, UK., García-Miñaúr S; Institute of Medical and Molecular Genetics, University Hospital La Paz, Madrid, 28046, Spain., Fernández L; Institute of Medical and Molecular Genetics, University Hospital La Paz, Madrid, 28046, Spain., Zhang ZD; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA., Goldmuntz E; Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Gur RE; Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania Philadelphia, Philadelphia, PA, 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Emanuel BS; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA., Zheng D; Department of Genetics, Department of Neurology, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, 10461, USA., Marshall CR; Division of Genome Diagnostics, The Hospital for Sick Children and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5T 1R8, Canada., Bassett AS; Clinical Genetics Research Program and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Dalglish Family 22q Clinic, Toronto General Hospital, and Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, M5T 1R8, Canada., Wang T; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA., Morrow BE; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. bernice.morrow@einsteinmed.edu.

Publikováno v: NPJ genomic medicine [NPJ Genom Med] 2023 Jul 18; Vol. 8 (1), pp. 17. Date of Electronic Publication: 2023 Jul 18.

HIV, asymptomatic STI, and the rectal mucosal immune environment among young men who have sex with men.

Autor: Van Doren VE; The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Smith SA; The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Hu YJ; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America., Tharp G; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Bosinger S; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America., Ackerley CG; The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Murray PM; The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Amara RR; Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America., Amancha PK; The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Arthur RA; Emory Integrated Computational Core, Emory University, Atlanta, Georgia, United States of America., Johnston HR; Emory Integrated Computational Core, Emory University, Atlanta, Georgia, United States of America., Kelley CF; The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Grady Health System, Atlanta, Georgia, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 May 30; Vol. 19 (5), pp. e1011219. Date of Electronic Publication: 2023 May 30 (Print Publication: 2023).

Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.

Autor: Seong CS; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA., Huang C; Cancer Animal Models Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Boese AC; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.; Cancer Biology Graduate Program, Laney Graduate School, Emory University, Atlanta, GA, USA., Hou Y; Cancer Animal Models Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Koo J; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA., Mouw JK; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA., Rupji M; Biostatistics Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Joseph G; Data and Technology Applications Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Johnston HR; Emory Integrated Computational Core, Emory University, Atlanta, GA., Claussen H; Emory Integrated Computational Core, Emory University, Atlanta, GA., Switchenko JM; Biostatistics Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Behera M; Data and Technology Applications Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Churchman M; M2Gen, Tampa, FL, USA., Kolesar JM; Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Arnold SM; Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Kerrigan K; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Akerley W; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Colman H; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Johns MA; Winship Cancer Institute of Emory University, Atlanta, GA, USA., Arciero C; Department of Surgery, Emory University School of Medicine, Atlanta, GA USA., Zhou W; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.; Winship Cancer Institute of Emory University, Atlanta, GA, USA., Marcus AI; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.; Winship Cancer Institute of Emory University, Atlanta, GA, USA., Ramalingam SS; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.; Winship Cancer Institute of Emory University, Atlanta, GA, USA., Fu H; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA., Gilbert-Ross M; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.; Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 27. Date of Electronic Publication: 2023 Jan 27.