Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Johnson Y.N. Lau"'
Autor:
Johnson Y.N. Lau, Her-Sheng Lin, Chia-Wei Liu, Pei-Yi Tsai, Gillian M.G. Lau, Kuo-Jang Kao, Shih-Hsien Chuang, Jiann-Jyh Huang, Jia-Ming Chang, Ying-Shuan Lee, Chia-Chi Chang, Lynn Y.L. Huang
Current cytotoxic chemotherapy produces clinical benefit in patients with breast cancer but the survival impact is modest. To explore novel cytotoxic agents for the treatment of advanced disease, we have characterized a new and pharmacokinetically im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3a1cce64a84b11cad22e18b8aee0b62
https://doi.org/10.1158/1535-7163.c.6536740.v1
https://doi.org/10.1158/1535-7163.c.6536740.v1
Autor:
Johnson Y.N. Lau, Her-Sheng Lin, Chia-Wei Liu, Pei-Yi Tsai, Gillian M.G. Lau, Kuo-Jang Kao, Shih-Hsien Chuang, Jiann-Jyh Huang, Jia-Ming Chang, Ying-Shuan Lee, Chia-Chi Chang, Lynn Y.L. Huang
PDF - 126K, Includes the methods for preparation of TAI-95, drug-drug synergy experiments, and preliminary subacute toxicology, Table S1: Combination index of TAI-95 with anticancer agents, and supplementary figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cd2d4da138a03a29f6a3af653804d2
https://doi.org/10.1158/1535-7163.22501294
https://doi.org/10.1158/1535-7163.22501294
Autor:
Ming Gao, Ian Ziyar, Ting Chen, Xuan Zhang, Xiaohong Liu, Jian Yang, Yong Liang, Winston Wang, Johnson Y.N. Lau, Ruiyun Deng, Zhihan Yan, Linsen Ye, Lianghong Zheng, Ye Sang, Kai Wang, Weimin Li, Laurance L Lau, Xiaoguang Zou, Oulan Li, Lingyan Zhang, Kang Zhang, Manson Fok, Wen Chen, Evis Sala, Longjiang Zhang, Zehong Yang, Jin Wang, Guiping Lin, Jun Shen, Tao Xu, Guangming Lu, Weihua Liao, Chengdi Wang, Zhongguo Zhou, Tianxin Lin, Charlotte Zhang, Tao Yu, Long Mo, Wenhua Liang, Andrea Olvera, Guangyu Wang, Jianxing He, Carola-Bibiane Schönlieb, Huimin Cai, Jichan Shi, Guiqun Cao, Zhihuan Li, Michael S. Roberts, Wei Chen, Wenqin Xu, Lei Yang, Xingwang Wu, Jun Liu
Publikováno v:
Nature biomedical engineering
Common lung diseases are first diagnosed using chest X-rays. Here, we show that a fully automated deep-learning pipeline for the standardization of chest X-ray images, for the visualization of lesions and for disease diagnosis can identify viral pneu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74f3d319f5574d7e1699ce7b03ed207
https://doi.org/10.1038/s41551-021-00704-1
https://doi.org/10.1038/s41551-021-00704-1
Autor:
Murray Cutler, Gwan-Sun Lee, Laura Pitzonka, Johnson Y.N. Lau, Sameer Urgaonkar, Kwee Hyun Suh, Michael Smolinski
Publikováno v:
Journal of Medicinal Chemistry. 64:3677-3693
Many chemotherapeutics, such as paclitaxel, are administered intravenously as they suffer from poor oral bioavailability, partly because of efflux mechanism of P-glycoprotein in the intestinal epithelium. To date, no drug has been approved by the U.S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6674af4b39b66155a74b47c713bfb8d3
https://doi.org/10.1021/acs.jmedchem.0c01826
https://doi.org/10.1021/acs.jmedchem.0c01826
Autor:
Muhammad Raza Shah, Samreen Fatima, Sehrosh Naz Khan, null Shafiullah, Gulshan Himani, Kelvin Wan, Timothy Lin, Johnson Y.N. Lau, Qingquan Liu, Dennis S.C. Lam
BackgroundKey findings from the World Health Organization Expert Meeting on Evaluation of Traditional Chinese Medicine in treating COVID-19 reported that TCMs are beneficial, particularly for mild-to-moderate cases. The efficacy of Jinhua Qinggan Gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a03d732b221f771dd5777bf89de25e
https://doi.org/10.1101/2022.05.16.22275074
https://doi.org/10.1101/2022.05.16.22275074
Publikováno v:
Precision Clinical Medicine
Editor's note A commentary on “Humoral immune response to SARS-CoV-2 in Iceland”.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5ed89b1b3d7c114a4526439f0c34ca
https://doi.org/10.1093/pcmedi/pbaa036
https://doi.org/10.1093/pcmedi/pbaa036
Autor:
Rebecca Lucinda Ka Yan Ho, Manson Fok, Joyce Jia Ying Gao, Michael Smolinski, Jia Hao Li, Weng Li Yoon, Denise So Bik Chan, Johnson Y.N. Lau, Wu Zeng, Christopher W.K. Lam, Betty Yuen Kwan Law, Ming Tsung Lee, Vincent Kam Wai Wong, Simon Wing Fai Mok, Xu Liang
Publikováno v:
Cancer Biology & Medicine, Vol 17, Iss 4, Pp 986-1001 (2020)
Objective: Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P-gp, which pumps its substrate back into the systemic circulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77f17a13656a7d6344eee61c531f2a3
http://www.cancerbiomed.org/index.php/cocr/article/view/1729
http://www.cancerbiomed.org/index.php/cocr/article/view/1729
Autor:
SL Lui, Efrat Kochba, Kwok-Hung Chan, Man-Fung Yuen, Johnson Y.N. Lau, Desmond Y H Yap, Ricky Ruiqi Zhang, Yotam Levin, Kwok-Yung Yuen, Tak Mao Chan, Ivan Hung, Kelvin K. W. To, Terence P.S. Yip, Sydney C.W. Tang
Publikováno v:
Clinical Infectious Diseases. 73:e304-e311
Background Patients on dialysis are hyporesponsive to the hepatitis B virus vaccines (HBVv). We examined intradermal (ID) HBVv Sci-B-Vac, with topical Toll-like receptor 7 (TLR7) agonist imiquimod pretreatment in dialysis patients. Methods We enrolle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44513d85a14c3aef5908da2bae0153f
https://doi.org/10.1093/cid/ciaa804
https://doi.org/10.1093/cid/ciaa804
Autor:
Parker Y.L. Tsang, Sunny L.H. Chu, Libby C.W. Li, Deborah M.S. Tai, Berry K.C. Cheung, Firaol Tamiru Kebede, Pete Y.M. Leung, Winston Wong, Teresa Chung, Cyril C.Y. Yip, Rosana Y.S. Poon, Jonathan Chen, Kwok-Yung Yuen, Manson Fok, Johnson Y.N. Lau, Lok-Ting Lau
Publikováno v:
IEEE Journal of Translational Engineering in Health and Medicine. :1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f662fe8bb8c0f23e88b0556f956f1e06
https://doi.org/10.1109/jtehm.2022.3230716
https://doi.org/10.1109/jtehm.2022.3230716
Autor:
Ning Li, Johnson Y.N. Lau, Jie Zhu, Qinjin Dai, Fanxin Zeng, Jianghai Liu, Andy Peng Xiang, Daniel T. Baptista-Hon, Peng Du, Shanyun Wu, Man Miao, Yong Wu, Zhongcheng Zhou, Charlotte Zhang, Hong Huang, Chengbin Guo, Haifeng Song, Xinxin Xiong, Gen Li, Edward Zhang, Kang Zhang, Lam Wai Ming, Meixing Yu, Zhihai Liu
Publikováno v:
Precision Clinical Medicine
To assess the impact of the key non-synonymous amino acid substitutions in the RBD of the spike protein of SARS-CoV-2 variant B.1.617.1 (dominant variant identified in the current India outbreak) on the infectivity and neutralization activities of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f097ba2b7a52984eeb612d2fb5cc0e96
https://pubmed.ncbi.nlm.nih.gov/35693215
https://pubmed.ncbi.nlm.nih.gov/35693215