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Advancing Tau-PET quantification in Alzheimer's disease with machine learning: introducing THETA, a novel tau summary measure.

Autor: Gebre RK; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Rial AM; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden., Raghavan S; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Wiste HJ; Department of Qualitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Johnson Sparrman KL; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Heeman F; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden., Costoya-Sánchez A; Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Nuclear Medicine Department and Molecular Imaging Group, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana s/n, Santiago de Compostela, 15706, Spain., Schwarz CG; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Spychalla AJ; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Lowe VJ; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA., Knopman DS; Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA., Petersen RC; Department of Qualitative Health Sciences, Mayo Clinic, Rochester, MN, USA.; Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA., Schöll M; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Nuclear Medicine Department and Molecular Imaging Group, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana s/n, Santiago de Compostela, 15706, Spain., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Vemuri P; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.

Publikováno v: Research square [Res Sq] 2023 Oct 18. Date of Electronic Publication: 2023 Oct 18.