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pro vyhledávání: '"Johnson Latisha C"'
Autor:
Rakesh Nagilla, Sharada Manns, Eugene L. Stewart, Marlys Hammond, Tram H. Hoang, Scott K. Thompson, Walter Trizna, Chaya Duraiswami, Eugene T. Grygielko, Thuy B. Tran, James S. Frazee, Kevin P. Madauss, Johnson Latisha C, Shawn P. Williams, Lindsay E. Glace, David G. Washburn, Jeffrey D. Bray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4664-4668
We have designed and synthesized a novel series of pyrrolidinones as progesterone receptor partial agonists. Compounds from this series had improved AR selectivity, rat pharmacokinetic properties, and in vivo potency compared to the lead compound. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e117925c53a26178fac52da1fa94885
https://doi.org/10.1016/j.bmcl.2009.06.081
https://doi.org/10.1016/j.bmcl.2009.06.081
Autor:
Eugene T. Grygielko, Patrick Stoy, Eugene L. Stewart, Tram H. Hoang, Johnson Latisha C, Jaclyn R. Patterson, Marlys Hammond, Qing Lu, Linda S. Barton, Rakesh Nagilla, David G. Washburn, Shawn P. Williams, Lara S. Kallander, Jeffrey D. Bray, Leonard M. Azzarano, Scott K. Thompson, Chaya Duraiswami, James S. Frazee, Kevin P. Madauss, Nicholas J. Laping, Xiaoping Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(1)
The previously reported pyrrolidine class of progesterone receptor partial agonists demonstrated excellent potency but suffered from serious liabilities including hERG blockade and high volume of distribution in the rat. The basic pyrrolidine amine w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c93d4e9e72254132d06ddbc41c09457
https://pubmed.ncbi.nlm.nih.gov/19926282
https://pubmed.ncbi.nlm.nih.gov/19926282
Autor:
Johnson, Latisha C.
Thesis (M.S.)--Louisiana State University, Baton Rouge, 2002.
Title from document title page.
Title from document title page.
Externí odkaz:
http://etd.lsu.edu/docs/available/etd-0927102-135929/
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