High and low levels of an NTRK2-driven genetic profile affect motor- and cognition-associated frontal gray matter in prodromal Huntington’s disease

Autor: Ciarochi, JA, Liu, J, Calhoun, V, Johnson, H, Misiura, M, Bockholt, HJ, Espinoza, FA, Caprihan, A, Plis, S, Turner, JA, Paulsen, JS, Long, JD, Johnson, HJ, Brashers-Krug, T, Danzer, P, Miller, A, Montross, K, Harrington, D, Westervelt, H, Aylward, E, Rao, S, Moser, DJ, Williams, J, Downing, N, Magnotta, VA, Vaidya, J, O Leary, D, Kim, EY, Kim, JI, Lourens, S, Zhang, Y, Lu, W, Erwin, C, Nance, M, Evans, J, Zschiegner, R, Chiu, E, Loi, S, Chua, P, Raymond, L, Ross, CA, Mallonee, WM, Samii, A, Jones, R, Barker, RA, McCusker, E, Loy, C, Orth, M, Süßmuth, S, Quaid, K, Guttman, M, Perlman, S, Geschwind, MD, Sha, S, Warner, T, Rosser, A, Marshall, F, Panegyres, P, Lee, J, Perlmutter, J, Miedzybrodzka, Z, Craufurd, D, Mazzoni, P, Marder, K, Kumar, R, Wheelock, V, Martin, W, Suchowersky, O, Ahmed, A, De Soriano, I, Shadrick, C, Preston, J, Goh, A, Antonopoulos, S, Komiti, A, Decolongon, J, Fan, M, Coleman, A, Varvaris, M, Ong, M, Yoritomo, N, Suter, G, Freney, EP, Macaraeg, A, Wood-Siverio, C, Factor, SA, Mason, S, Guzman, NV, Griffith, J, McMillan, J

This study assessed how BDNF (brain-derived neurotrophic factor) and other genes involved in its signaling influence brain structure and clinical functioning in pre-diagnosis Huntington’s disease (HD). Parallel independent component analysis (pICA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33155136ae8c0931d45a171af69ae26
https://www.repository.cam.ac.uk/handle/1810/285331

Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: A decade of the PREDICT-HD study

Autor: Paulsen, JS, Long, JD, Johnson, HJ, Aylward, EH, Ross, CA, Williams, JK, Nance, MA, Erwin, CJ, Westervelt, HJ, Harrington, DL, Bockholt, HJ, Zhang, Y, McCusker, EA, Chiu, EM, Panegyres, PK, Cross, S, Ryan, P, Epping, EA, Preston, J, Goh, A, Antonopoulos, S, Loi, S, Raymond, L, Decolongon, J, Fan, M, Coleman, A, Mallone, WM, Suter, G, Varvaris, M, Yoritomo, N, Griffith, J, Loy, C, Gunn, D, Guttman, M, Sheinberg, A, Law, A, Quaid, K, Wesson, M, Wojcieszek, J, Perlmutter, J, Barton, S, Smith, S, Barker, RA, Mason, S, Guzman, NV, Perlman, S, Clemente, B, Jones, R, Wood-Siverio, C, Factor, SA, Samii, A, Macaraeg, A, Lee, J, Tedesco, M, Maxwell, B, Kumar, R, Erickson, D, Nickels, B, Marshall, F, Chesire, A, Wodarski, M, Hickey, C, Geschwind, MD, Sha, S, Satris, G, Ahmed, A, Reece, C, Bura, A, Mourany, L, Pillai, J, Mazzoni, P, Marder, K, Wasserman, P, Craufurd, D, Bek, J, Howard, E, Warner, T, Burrows, M, Orth, M, Süßmuth, S, Barth, K, Trautmann, S, Schwenk, D, Eschenbach, C, Wheelock, V, Kjer, L, Martin, A, Farias, S, Miedzybrodzka, Z, Rae, D

Publikováno v: Paulsen, JS; Long, JD; Johnson, HJ; Aylward, EH; Ross, CA; Williams, JK; et al.(2014). Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: A decade of the PREDICT-HD study. Frontiers in Aging Neuroscience, 6(APR). doi: 10.3389/fnagi.2014.00078. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2ms8c2jv

There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::7c22eace304dad4db3ecfcceb9b14282
http://www.escholarship.org/uc/item/2ms8c2jv

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