Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Johnson, Rajasingh"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Drug resistance has been a major obstacle in the quest for a cancer cure. Many chemotherapeutic treatments fail to overcome chemoresistance, resulting in tumor remission. The exact process that leads to drug resistance in many cancers has not been fu
Externí odkaz:
https://doaj.org/article/2aeadcab3b3c4bb2b18d0bed59507b3c
Autor:
Talan Tran, Claudia Cruz, Anthony Chan, Salma Awad, Johnson Rajasingh, Richard Deth, Narasimman Gurusamy
Publikováno v:
Cells, Vol 12, Iss 18, p 2268 (2023)
Cardiac injury, such as myocardial infarction and heart failure, remains a significant global health burden. The limited regenerative capacity of the adult heart poses a challenge for restoring its function after injury. Mesenchymal stem cells (MSCs)
Externí odkaz:
https://doaj.org/article/8f8e4eda217d42aca30ae03a0d6631d8
Autor:
Selvaraj Jayaraman, Dhanavathy Gnanasampanthapandian, Johnson Rajasingh, Kanagaraj Palaniyandi
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Owing to myocardial abnormalities, cardiac ailments are considered to be the major cause of morbidity and mortality worldwide. According to a recent study, membranous vesicles that are produced naturally, termed as “exosomes”, have emerged as the
Externí odkaz:
https://doaj.org/article/3b7500e0ec0a404ca19321b0bcc5795f
Autor:
Saiprahalad Mani, Narasimman Gurusamy, Thennavan Ulaganathan, Autumn J Paluck, Satish Ramalingam, Johnson Rajasingh
Publikováno v:
Experimental Biology and Medicine. 248:434-444
Exosomes are extracellular vesicles released by many cell types with varying compositions. Major bioactive factors present in exosomes are protein, lipid, mRNA, and miRNA. Exosomes are fundamental regulators of cellular trafficking and signaling in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67b82ca6966ffa6dde9dfe2e23190047
https://doi.org/10.1177/15353702231151960
https://doi.org/10.1177/15353702231151960
Autor:
Mona Agrawal, Pratheepa Kumari Rasiah, Amandeep Bajwa, Johnson Rajasingh, Rajashekhar Gangaraju
Publikováno v:
Cells, Vol 10, Iss 11, p 3006 (2021)
Mesenchymal stem/stromal cells (MSC) are well known for immunomodulation; however, the mechanisms involved in their benefits in the ischemic retina are unknown. This study tested the hypothesis that MSC induces upregulation of transcription factor fo
Externí odkaz:
https://doaj.org/article/5b3eccd8adc242a59fafe8dd71b0c560
Autor:
Jayavardini Vasanthan, Narasimman Gurusamy, Sheeja Rajasingh, Vinoth Sigamani, Shivaani Kirankumar, Edwin L. Thomas, Johnson Rajasingh
Publikováno v:
Cells, Vol 10, Iss 1, p 54 (2020)
Mesenchymal stem cells (MSCs) are multipotent cells which can proliferate and replace dead cells in the body. MSCs also secrete immunomodulatory molecules, creating a regenerative microenvironment that has an excellent potential for tissue regenerati
Externí odkaz:
https://doaj.org/article/bd84b19ef6dc46fc86db29771467ae52
Publikováno v:
Current Genomics. 22:526-540
Aims: Perform in-silico analysis of human SOS1 mutations to elucidate their pathogenic role in Noonan syndrome (NS). Background: NS is an autosomal dominant genetic disorder caused by single nucleotide mutation in PTPN11, SOS1, RAF1, and KRAS genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d156fe50094445e80c70b279e79160a0
https://doi.org/10.2174/1389202922666211130144221
https://doi.org/10.2174/1389202922666211130144221
Autor:
Selene G Perales, Johnson Rajasingh, Jayavardini Vasanthan, Narasimman Gurusamy, Vinoth Sigamani, Sheeja Rajasingh, Shivaani Kirankumar
Publikováno v:
Exp Biol Med (Maywood)
The process of bone repair has always been a natural mystery. Although bones do repair themselves, supplemental treatment is required for the initiation of the self-regeneration process. Predominantly, surgical procedures are employed for bone regene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729d9eb7d454a5e21b46705ea511a260
https://doi.org/10.1177/15353702211052927
https://doi.org/10.1177/15353702211052927
Publikováno v:
Circulation Research. 131
Background: Current stem cells therapy for ischemic cardiomyopathy is effective only about 2-4% in improving cardiac function. In search of novel therapy, we have developed a safe mRNA-based reprogramming of non-invasively derived human urinary epith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44911eddcccb66f459c87727b57d555e
https://doi.org/10.1161/res.131.suppl_1.p1038
https://doi.org/10.1161/res.131.suppl_1.p1038
Publikováno v:
Circulation Research. 131
Background: Hutchinson-Gilford progeria (HGP) is a rare genetic disorder in which children age rapidly. They suffer from atherosclerosis, cardiovascular diseases, and strokes. The LMNA variant c.1824C>T accounts for ~90% of HGP cases. This variant ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3086fc430feb0cd665170f959dba7305
https://doi.org/10.1161/res.131.suppl_1.p2111
https://doi.org/10.1161/res.131.suppl_1.p2111