Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Johnson, Paul David"'
Autor:
Johnson, Paul David
Publikováno v:
Phylon (1960-), 1975 Dec 01. 36(4), 426-434.
Externí odkaz:
https://www.jstor.org/stable/274642
Autor:
Johnson, Paul David
Publikováno v:
American Literature, 1977 Mar 01. 49(1), 22-33.
Externí odkaz:
https://www.jstor.org/stable/2925551
Autor:
Morris Jeffrey James, Gordon S. Currie, Jason Grant Kettle, Claire Crafter, Clare Lane, Ken Page, Peter Ballard, Linette Ruston, Hannah Dry, Martin Pass, Andrew G. Leach, Ryan Greenwood, Matt Addie, Judit E. Debreczeni, Johnson Paul David, Barry R. Davies, Gillian M. Lamont, Donald J. Ogilvie, David Buttar, Philippa Dudley, Richard W. A. Luke, Stuart E. Pearson
Publikováno v:
Journal of Medicinal Chemistry. 56:2059-2073
Wide-ranging exploration of analogues of an ATP-competitive pyrrolopyrimidine inhibitor of Akt led to the discovery of clinical candidate AZD5363, which showed increased potency, reduced hERG affinity, and higher selectivity against the closely relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e89f0e75ec3075ae6b777ac8b9c2c94
https://doi.org/10.1021/jm301762v
https://doi.org/10.1021/jm301762v
Autor:
Johnson, Paul David
Publikováno v:
Early American Literature, 1981 Dec 01. 16(3), 270-281.
Externí odkaz:
https://www.jstor.org/stable/25056437
Autor:
Iain Simpson, Craig A. Roberts, Carr Gregory Richard, David Alan Rudge, Gail L. Wrigley, James L. Feron, Johnson Paul David
Publikováno v:
Tetrahedron Letters. 53:5049-5055
The development of a novel palladium-catalysed amidation approach towards 5,7,8,9-tetrahydropyrimido[4,5- b ][1,4]diazepin-6-one templates is highlighted. The route proceeds through the reaction of an amino amide, generated by 1,4-addition of an amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::279e51c452fc417762cb062c5c389821
https://doi.org/10.1016/j.tetlet.2012.03.125
https://doi.org/10.1016/j.tetlet.2012.03.125
Autor:
Annie Olivier, Jason Grant Kettle, Donald J. Ogilvie, Martin Pass, Peter Ballard, Andrew G. Leach, Craig S. Harris, Nicolas Warin, Rémy Morgentin, Teresa Klinowska, Emma J. Williams, Laurent Francois Andre Hennequin, Robert Hugh Bradbury, Johnson Paul David, Mark Hickinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1633-1637
A series of novel C-5 substituted anilinoquinazolines, selected on the basis of docking experiments and overlays with ATP in the active site of EGFR tyrosine kinase, have been prepared and found to be potent inhibitors. In vivo pharmacokinetics and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c44e51cb3ecc3e68f9e8a56095c78ec
https://doi.org/10.1016/j.bmcl.2005.12.028
https://doi.org/10.1016/j.bmcl.2005.12.028
Autor:
Rémy Morgentin, Peter Ballard, D. Mark Hickinson, Laurent Francois Andre Hennequin, Johnson Paul David, Donald J. Ogilvie, Robert Hugh Bradbury, Teresa Klinowska, Jason Grant Kettle, Annie Olivier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4226-4229
Starting from a 6,7-substituted quinazoline lead 4, optimisation of 5-substituted quinazolines containing an extended aniline motif led to potent and selective inhibitors of erbB2 receptor tyrosine kinase, and a representative compound 12a inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96829569526116303bbf291985fb43e9
https://doi.org/10.1016/j.bmcl.2005.06.068
https://doi.org/10.1016/j.bmcl.2005.06.068
Publikováno v:
Tetrahedron Letters. 52:1154-1156
Both (±)-protoemetinol, its 3-epi-isomer and (±)-3-desmethyl protoemetinol have been prepared in five linear steps from a dihydroisoquinoline using a 6-exo-trig cyclisation of a vinyl radical in the key step. This novel and particularly short route
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5fb96415e0b2d32cbbc92f59c5b9c35
https://doi.org/10.1016/j.tetlet.2011.01.007
https://doi.org/10.1016/j.tetlet.2011.01.007
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1109-1116
Styrene and a range of aryl-substituted styrene derivatives are shown to undergo efficient carbolithiation–trapping reactions in diethyl ether at −78 to −25 °C. The reactivities of different types of organolithium reagents were found to be: te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::875e69702d4fdbe5d3dfb0eca4fd7326
https://doi.org/10.1039/a910195k
https://doi.org/10.1039/a910195k
Publikováno v:
Tetrahedron Letters. 45:3733-3735
The synthetic strategy towards a 5-alkoxypyrido[3,4-d]pyrimidin-4(3H)-one is described, utilizing palladium catalyzed amination of a bromopyridine, and subsequent directed ortho-metallation/carboxylation as the key steps.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ceb8bd7f44b772a106fbc252b3a495c
https://doi.org/10.1016/j.tetlet.2004.03.087
https://doi.org/10.1016/j.tetlet.2004.03.087