Neuron-targeted Knockout of APE1 Forces Premature Cognitive Impairment and Synaptic Dysfunction in Adult Mice.

Autor: Zhu L; 1Pittsburgh Institute of Brain Disorder & Recovery and Department of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Hassan SH; 1Pittsburgh Institute of Brain Disorder & Recovery and Department of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; 2Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA., Gao X; 1Pittsburgh Institute of Brain Disorder & Recovery and Department of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Johnson JQ; 1Pittsburgh Institute of Brain Disorder & Recovery and Department of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Wang Y; 1Pittsburgh Institute of Brain Disorder & Recovery and Department of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Bregy MV; 1Pittsburgh Institute of Brain Disorder & Recovery and Department of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Wei Z; 1Pittsburgh Institute of Brain Disorder & Recovery and Department of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Chen J; 1Pittsburgh Institute of Brain Disorder & Recovery and Department of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; 2Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA., Li P; 1Pittsburgh Institute of Brain Disorder & Recovery and Department of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Stetler RA; 1Pittsburgh Institute of Brain Disorder & Recovery and Department of Neurology University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; 2Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA.

Publikováno v: Aging and disease [Aging Dis] 2022 Dec 01; Vol. 13 (6), pp. 1862-1874. Date of Electronic Publication: 2022 Dec 01 (Print Publication: 2022).