The FOXP3 ⁺ Pro-Inflammatory T Cell: A Potential Therapeutic Target in Crohn's Disease.

Autor: Kosinsky RL; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Gonzalez MM; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Saul D; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota; Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center, Tübingen, Germany., Barros LL; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil., Sagstetter MR; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Fedyshyn Y; Department of Physiology, Mayo Clinic, Rochester, Minnesota., Nair A; Division of Computational Biology, Mayo Clinic, Rochester, Minnesota., Sun Z; Division of Computational Biology, Mayo Clinic, Rochester, Minnesota., Hamdan FH; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Gibbons HR; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Perez Pachon ME; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Druliner BR; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Johnsen SA; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Faubion WA; Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona. Electronic address: Faubion.william@mayo.edu.

Publikováno v: Gastroenterology [Gastroenterology] 2024 Apr; Vol. 166 (4), pp. 631-644.e17. Date of Electronic Publication: 2024 Jan 09.

An NFATc1/SMAD3/cJUN Complex Restricted to SMAD4-Deficient Pancreatic Cancer Guides Rational Therapies.

Autor: Hasselluhn MC; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Department of Medicine, Division of Digestive and Liver Diseases, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Schlösser D; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Versemann L; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Schmidt GE; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany., Ulisse M; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany., Oschwald J; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany., Zhang Z; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany., Hamdan F; Gene Regulatory Mechanisms and Molecular Epigenetics Laboratory, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Xiao H; Department of Medicine, Division of Digestive and Liver Diseases, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Kopp W; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany., Spitalieri J; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany., Kellner C; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany., Schneider C; Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany., Reutlinger K; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Nagarajan S; Manchester Breast Centre and Manchester Cancer Research Centre, Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Steuber B; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Sastra SA; Department of Medicine, Division of Digestive and Liver Diseases, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Palermo CF; Department of Medicine, Division of Digestive and Liver Diseases, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Appelhans J; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany; Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany., Bohnenberger H; Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany., Todorovic J; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany; Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany., Kostyuchek I; Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany., Ströbel P; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany; Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany., Bockelmann A; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., König A; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Ammer-Herrmenau C; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany., Schmidleitner L; Medical Clinic and Polyclinic II, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany; Translational Pancreatic Research Cancer Center, Medical Clinic and Polyclinic II, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany., Kaulfuß S; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany; Institute of Human Genetics, University Medical Center Goettingen, Goettingen, Germany., Wollnik B; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany; Institute of Human Genetics, University Medical Center Goettingen, Goettingen, Germany; Cluster of Excellence Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells, University of Goettingen, Germany., Hahn SA; Ruhr University Bochum, Faculty of Medicine, Department of Molecular Gastrointestinal Oncology, Bochum, Germany., Neesse A; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany., Singh SK; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany., Bastians H; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany; Department of Molecular Oncology, Section for Cellular Oncology, University Medical Center Goettingen, Goettingen, Germany., Reichert M; Medical Clinic and Polyclinic II, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany; Translational Pancreatic Research Cancer Center, Medical Clinic and Polyclinic II, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany; German Cancer Consortium (a partnership between Deutsches Krebsforschungszentrum and University Hospital Klinikum Rechts der Isar), Munich, Germany; Center for Protein Assemblies, Technical University of Munich, Garching, Germany; Center for Organoid Systems and Tissue Engineering, Technical University Munich, Garching, Germany., Sax U; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany; Department of Medical Informatics, University Medical Center Goettingen, Goettingen, Germany., Olive KP; Department of Medicine, Division of Digestive and Liver Diseases, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Johnsen SA; Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Schneider G; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany; Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany; Comprehensive Cancer Center, Lower Saxony, Goettingen and Hannover, Germany., Ellenrieder V; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany; Comprehensive Cancer Center, Lower Saxony, Goettingen and Hannover, Germany., Hessmann E; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany; Clinical Research Unit KFO5002, University Medical Center Goettingen, Goettingen, Germany; Comprehensive Cancer Center, Lower Saxony, Goettingen and Hannover, Germany. Electronic address: elisabeth.hessmann@med.uni-goettingen.de.

Publikováno v: Gastroenterology [Gastroenterology] 2024 Feb; Vol. 166 (2), pp. 298-312.e14. Date of Electronic Publication: 2023 Oct 31.

RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer.

Autor: Prokakis E; Department of Gynecology and Obstetrics, University Medical Center Göttingen, Göttingen, Germany. eprokak@gwdg.de.; Department of General, Visceral & Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. eprokak@gwdg.de., Jansari S; Department of Gynecology and Obstetrics, University Medical Center Göttingen, Göttingen, Germany., Boshnakovska A; Department of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany., Wiese M; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany., Kusch K; Institute for Auditory Neuroscience, Functional Auditory Genomics Group, University Medical Center Göttingen, Göttingen, Germany., Kramm C; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany., Dullin C; Institute for Diagnostic and Interventional Radiology, University Medical Center Göttingen, Göttingen, Germany.; Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.; Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Rehling P; Department of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany., Glatzel M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pantel K; Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wikman H; Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Johnsen SA; Department of General, Visceral & Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; The Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Gallwas J; Department of Gynecology and Obstetrics, University Medical Center Göttingen, Göttingen, Germany., Wegwitz F; Department of Gynecology and Obstetrics, University Medical Center Göttingen, Göttingen, Germany. fwegwit@gwdg.de.; Department of General, Visceral & Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. fwegwit@gwdg.de.

Publikováno v: Cell death & disease [Cell Death Dis] 2023 Sep 28; Vol. 14 (9), pp. 641. Date of Electronic Publication: 2023 Sep 28.

Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer.

Autor: Hamdan FH; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA Steven.Johnsen@bosch-health-campus.com Hamdan.Feda@mayo.edu.; Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA., Abdelrahman AM; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Kutschat AP; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Wang X; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Ekstrom TL; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Jalan-Sakrikar N; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Wegner Wippel C; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Taheri N; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Tamon L; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Kopp W; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany.; Clinical Research Unit 5002 (KFO5002), University Medical Center Göttingen, Göttingen, Germany., Aggrey-Fynn J; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Bhagwate AV; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Alva-Ruiz R; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Lynch I; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Yonkus J; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Kosinsky RL; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Gaedcke J; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Hahn SA; Department of Molecular GI Oncology, Ruhr University Bochum, Bochum, Germany., Siveke JT; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center (DKFZ), Heidelberg, Germany., Graham R; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Najafova Z; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Hessmann E; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany.; Clinical Research Unit 5002 (KFO5002), University Medical Center Göttingen, Göttingen, Germany., Truty MJ; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Johnsen SA; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany Steven.Johnsen@bosch-health-campus.com Hamdan.Feda@mayo.edu.

Publikováno v: Gut [Gut] 2023 Jun; Vol. 72 (6), pp. 1174-1185. Date of Electronic Publication: 2023 Mar 08.

EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6 .

Autor: Patil S; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Steuber B; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Kopp W; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Kari V; Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany., Urbach L; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Wang X; Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany., Küffer S; Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany., Bohnenberger H; Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany., Spyropoulou D; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Zhang Z; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Versemann L; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Bösherz MS; Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany., Brunner M; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Gaedcke J; Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany., Ströbel P; Institute of Pathology, University Medical Center Goettingen, Goettingen, Germany., Zhang JS; Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang, PR China.; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, Minnesota., Neesse A; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Ellenrieder V; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Singh SK; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany., Johnsen SA; Department of General, Visceral and Pediatric Surgery, University Medical Center Goettingen, Goettingen, Germany.; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Hessmann E; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany. elisabeth.hessmann@med.uni-goettingen.de.

Publikováno v: Cancer research [Cancer Res] 2020 Nov 01; Vol. 80 (21), pp. 4620-4632. Date of Electronic Publication: 2020 Sep 09.