Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Johnny Yasuo Nagasawa"'
Autor:
Grace Reyes-Manalo, Edwin J. Schweiger, Mitchell D. Green, Janice Chung, Christopher D. King, Johnny Yasuo Nagasawa, Nicholas D. P. Cosford, Peter C. Chua, Jeffrey Anderson, Merryl Cramer, Lida Tehrani, Benito Munoz, Leo Bleicher
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(20)
Structure-activity relationship studies leading to the discovery of novel mGlu5 receptor antagonists are described. These compounds show high in vitro potency, have good in vivo receptor occupancy, and a reasonable intravenous pharmacokinetic profile