Výsledky vyhledávání - "Johnny Y. Wu"

In vivoimaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome

Autor: Ali M Berri, Geoffrey G. Murphy, Shaniya Maimaiti, Catherine Tran, Robert H. Podolsky, Nikita Khetarpal, Fatema Shafie-Khorassani, Bruce A. Berkowitz, Kristin Dernay, Johnny Y. Wu, John C. Gant, Brian M. Bennett, Olivier Thibault, Jacob Lenning, E. Mark Haacke, Robin Roberts

Publikováno v: The FASEB Journal. 31:4179-4186

Hippocampus oxidative stress is considered pathogenic in neurodegenerative diseases, such as Alzheimer disease (AD), and in neurodevelopmental disorders, such as Angelman syndrome (AS). Yet clinical benefits of antioxidant treatment for these disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598c98f55753d5e36a9c3a9f6712687c
https://doi.org/10.1096/fj.201700229r

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Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1

Autor: Katarzyna A. Piechowicz, Kashif M. Javed, Puay Wah Phuan, Johnny Y. Wu, Rachelle R. Chaney, Alan S. Verkman, Marc O. Anderson, Eric C. Truong

Publikováno v: Journal of enzyme inhibition and medicinal chemistry, vol 31, iss 6

Transmembrane protein 16A (TMEM16A), also called Ano1, is a Ca2+ activated Cl− channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and electrically excitable cells. TMEM16A inhibitors have potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66dd9222075b689cf114d14f4194f947
https://escholarship.org/uc/item/1nw8t6k6

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Sodium Iodate Produces a Strain-Dependent Retinal Oxidative Stress Response Measured In Vivo Using QUEST MRI

Autor: Ali M Berri, Johnny Y. Wu, Fatema Shafie-Khorassani, Bruce A. Berkowitz, Nikita Khetarpal, Robin Roberts, Catherine Tran, Jacob Lenning, Kristin Dernay, Robert H. Podolsky

Publikováno v: Investigative Ophthalmology & Visual Science

Purpose We identify noninvasive biomarkers that measure the severity of oxidative stress within retina layers in sodium iodate (SI)-atrophy vulnerable (C57BL/6 [B6]) and SI-atrophy resistant (129S6/SvEvTac [S6]) mice. Methods At 24 hours after admini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422aee7902cba51a9e51d8598ec5d903
https://doi.org/10.1167/iovs.17-21850

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