Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Johnny Sandberg"'
Autor:
Martin Hegen, David C. Wood, Patrik Rhönnstad, Felix Vajdos, Atli Thorarensen, Mark E. Schnute, Timothy Braden, Kimberly Crouse, Maria Sjöberg, John I. Trujillo, Ravi G. Kurumbail, Bolette Husman, Konrad F. Koehler, Mattias Wennerstål, Tomas Bonn, Joakim Löfstedt, Eva Backström-Rydin, Bo Carlsson, Aron Sundell, Ming Z. Chen, Steven E. Heasley, John David Trzupek, Annika Goos-Nilsson, Carol A. Menard, Peter Harris, James R. Kiefer, Martin Bengtsson, Leon P. Collis, Michael J. Prinsen, Philippe Nuhant, Jennifer Alley, Scott A. Long, Alexander E. Hromockyj, Andrew C. Flick, Johnny Sandberg, Christoph W. Zapf, Edouard Zamaratski, Xiao Hu, Lee Napierata, Björn Kauppi, Nicole Caspers, Kimberly F. Fennell, Robert E. Kyne, Gabriel Berstein, Neelu Kaila, Lars Kruger, Wei Li, Li Xing, Ray Unwalla, Elisabet Kallin, Matthew J. Pelc, Susan Fish, James Robert Blinn, Hjalmar Gullberg, Marvin J. Meyers, Scot Richard Mente, Chulho Choi, Falgun Shah, Mathias Färnegårdh, Dean Messing, Peter G. Jones, Yajuan Zhao, Alexandria P. Taylor, Maria Sandström, Charles W. Bolten, Daniel Nöteberg, Robin A. Weinberg, Tomasz Janosik, John D. Knafels, Anna Wilhelmsson
Publikováno v:
Journal of medicinal chemistry. 61(23)
The nuclear hormone receptor retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) is a promising target for the treatment of autoimmune diseases. A small molecule, inverse agonist of the receptor is anticipated to reduce production
Autor:
Todd J. Friends, Arthur M. Doweyko, Johnny Sandberg, Jon J. Hangeland, Denis E. Ryono, Karin Mellstroem, Marlena Grynfarb
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4579-4584
High affinity thyromimetics containing a novel phenyl-naphthylene core are reported. The functionalized core is readily accessible via a Suzuki coupling protocol. Examples of this new class of TR ligands have sub-nanomolar binding affinities for the
Autor:
Johnny Sandberg, Karin Mellström, Mahmoud Rahimi-Ghadim, Denis E. Ryono, Gary J. Grover, Zhang Minsheng, Peter Agback, Neeraj Garg, William N. Washburn, Marlena Grynfarb, Ana Maria Garcia Collazo, Yolanda Caringal, Wei Meng, Robert Paul Brigance, Yi-Lin Li, Stefan Rehnmark, Chris Litten, Johan Malm, Thomas Anders Norin
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(15)
Based on the scaffold of the pharmacologically selective thyromimetic 2b, structurally a close analog to KB-141 (2a), a number of novel N-acylated-α-amino acid derivatives were synthesized and tested in a TR radioligand binding assay as well as in a
Autor:
Liu Ye, Ana-Maria Garcia Collazo, Mathias Färnegårdh, Konrad F. Koehler, Karin Mellström, Johnny Sandberg, Harri Ahola, Bolette Husman, Johan Malm, Jan Ljunggren, Marlena Grynfarb, Neeraj Garg
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(5)
Based on the examination of the crystal structure of rat TRbeta complexed with 3,5,3'-triiodo-l-thyronine (2) a novel TRbeta-selective indole derivative 6b was prepared and tested in vitro. This compound was found to be 14 times selective for TRbeta
Autor:
Bolette Husman, Yi-Lin Li, Konrad F. Koehler, Johan Malm, Ana Maria Garcia Collazo, Chris Litten, Mathias Färnegård, Neeraj Garg, Karin Mellström, Johnny Sandberg, Marlena Grynfarb
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(4)
Based on the examination of the X-ray crystallographic structures of the LBD of TRalpha and TRbeta in complex with KB-141 (2), a number of novel 4'-hydroxy bioisosteric thyromimetics were prepared. Optimal affinity and beta-selectivity (33 times), wa
Autor:
Konrad F. Koehler, Todd J. Friends, Marlena Grynfarb, Pratik Devasthale, Arthur M. Doweyko, Bolette Husman, Howard Einspahr, Jon J. Hangeland, John S. Sack, Tamara Dejneka, Jan Ljunggren, Cheryl M. Sheppard, Karin Mellström, Johnny Sandberg, Denis E. Ryono, Mathias Färnegårdh, Johan Malm
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(13)
A set of thyromimetics having improved selectivity for TR-beta1 were prepared by replacing the 3'-isopropyl group of 2 and 3 with substituents having increased steric bulk. From this limited SAR study, the most potent and selective compounds identifi
Autor:
Marlena Grynfarb, Karin Mellström, Todd J. Friends, Denis E. Ryono, Jon J. Hangeland, Arthur M. Doweyko, Johnny Sandberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:473