Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Johnny M. Tkach"'
Autor:
Mohamed Bourmoum, Nikolina Radulovich, Amit Sharma, Johnny M. Tkach, Ming-Sound Tsao, Laurence Pelletier
Publikováno v:
PLoS ONE, Vol 19, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/4dc1eaca35f8420a9ca03e7b2058e690
Autor:
Yi Luo, Miriam Barrios-Rodiles, Gagan D. Gupta, Ying Y. Zhang, Abiodun A. Ogunjimi, Mikhail Bashkurov, Johnny M. Tkach, Ainsley Q. Underhill, Liang Zhang, Mohamed Bourmoum, Jeffrey L. Wrana, Laurence Pelletier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Centrosomes function in cell migration by organizing microtubules. Here, Luo et al. surprisingly show that centrosome proteins also control migration after recruitment by Wnt-PCP proteins to the cell cortex, leading to actin remodelling and protrusiv
Externí odkaz:
https://doaj.org/article/27bacde2ea6a46fba858d213b47a28a9
Autor:
Johnny M Tkach, Reuben Philip, Amit Sharma, Jonathan Strecker, Daniel Durocher, Laurence Pelletier
Publikováno v:
eLife, Vol 11 (2022)
Centrosomes act as the main microtubule organizing center (MTOC) in metazoans. Centrosome number is tightly regulated by limiting centriole duplication to a single round per cell cycle. This control is achieved by multiple mechanisms, including the r
Externí odkaz:
https://doaj.org/article/fc695c50222a47249da3873639dc6225
Autor:
Johnny M Tkach, Reuben Philip, Amit Sharma, Jonathan Strecker, Daniel Durocher, Laurence Pelletier
Publikováno v:
eLife. 11
Centrosomes act as the main microtubule organizing center (MTOC) in metazoans. Centrosome number is tightly regulated by limiting centriole duplication to a single round per cell cycle. This control is achieved by multiple mechanisms, including the r
Centrosomes act as the main microtubule organizing centre (MTOC) in metazoans. Centrosome number is tightly regulated by limiting centriole duplication to a single round per cell cycle. This control is achieved by multiple mechanisms, including the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e394b049419287db8b0e09d49259ce
https://doi.org/10.1101/2021.06.25.449796
https://doi.org/10.1101/2021.06.25.449796
Autor:
Laurence Pelletier, Ciaran G. Morrison, Suzanna L. Prosser, Johnny M. Tkach, Ladan Gheiratmand
Protein degradation at the centrosome, the primary microtubule organizing centre of the cell, is critical to a myriad of cellular processes. Perturbation of the ubiquitin proteasome system causes the formation of an inclusion, or aggresome, at the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03c46c6b0b92eb585360085b2eb20796
https://doi.org/10.1101/2020.12.20.423672
https://doi.org/10.1101/2020.12.20.423672
Autor:
Laurence Pelletier, Ying Y. Zhang, Abiodun A. Ogunjimi, Miriam Barrios-Rodiles, Yi Luo, Gagan D. Gupta, Mikhail Bashkurov, Ainsley Q. Underhill, Johnny M. Tkach, Jeffrey L. Wrana, Liang Zhang, Mohamed Bourmoum
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Centrosomes control cell motility, polarity and migration that is thought to be mediated by their microtubule-organizing capacity. Here we demonstrate that WNT signalling drives a distinct form of non-directional cell motility that requires a key cen
Autor:
Laurence Pelletier, Sally W.T. Cheung, Qianzhu Wu, João Gonçalves, James D.R. Knight, David Comartin, Monica Hasegan, Markus Schueler, Jason Moffat, Johnny M. Tkach, Yi Liu, Anne-Claude Gingras, Zhen-Yuan Lin, Bahareh A. Mojarad, Ladan Gheiratmand, Mikhail Bashkurov, Brian Raught, Friedhelm Hildebrandt, Gagan D. Gupta, Etienne Coyaud
Publikováno v:
Cell. 163(6):1484-1499
SummaryThe centrosome is the primary microtubule organizing center of the cells and templates the formation of cilia, thereby operating at a nexus of critical cellular functions. Here, we use proximity-dependent biotinylation (BioID) to map the centr