Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Johnny L, Carson"'
Autor:
Patrick R. Sears, Hanan E. Shamseldin, Heymut Omran, Katharine E. Black, Maimoona A. Zariwala, Vladimir Vinarsky, Evgeni M. Frenkel, David M. Sabatini, Hui Min Leung, Fowzan S. Alkuraya, Michael R. Knowles, Guillermo J. Tearney, Lida P. Hariri, M. Leigh Anne Daniels, Jason H. Yang, Martin S. Taylor, Raghu R. Chivukula, Johnny L. Carson, Ibrahim Almogarri, Daniel T. Montoro, Gerard W. Dougherty
Publikováno v:
Nature medicine
Mucociliary clearance, the physiological process by which mammalian conducting airways expel pathogens and unwanted surface materials from the respiratory tract, depends on the coordinated function of multiple specialized cell types, including basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7539e9fb4752cea492452be2bc182b
https://doi.org/10.1038/s41591-019-0730-x
https://doi.org/10.1038/s41591-019-0730-x
Autor:
Katelyn S. Lavrich, Phillip W. Clapp, Eduardo R. Lazarowski, Ilona Jaspers, Johnny L. Carson, Catharina van Heusden
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 316:L470-L486
Aldehydes in cigarette smoke (CS) impair mitochondrial function and reduce ciliary beat frequency (CBF), leading to diminished mucociliary clearance (MCC). However, the effects of aldehyde e-cigarette flavorings on CBF are unknown. The purpose of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b0017a1e69eb53392578e7f8295f15
https://doi.org/10.1152/ajplung.00304.2018
https://doi.org/10.1152/ajplung.00304.2018
Autor:
Hanan E. Shamseldin, Jason H. Yang, Guillermo J. Tearney, Martin S. Taylor, Gerard W. Dougherty, Raghu R. Chivukula, Daniel T. Montoro, Johnny L. Carson, Heymut Omran, Evgeni M. Frenkel, M. Leigh Anne Daniels, David M. Sabatini, Ibrahim Almogarri, Lida P. Hariri, Michael R. Knowles, Hui Min Leung, Fowzan S. Alkuraya, Katharine E. Black, Maimoona A. Zariwala, Vladimir Vinarsky, Patrick R. Sears
Publikováno v:
Nat Med
Mucociliary clearance, the physiological process by which mammalian conducting airways expel pathogens and unwanted surface materials from the respiratory tract, depends on the coordinated function of multiple specialized cell types, including basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f74d7f4165f0a364a65e73d2c21205
https://doi.org/10.1038/s41591-020-0773-z
https://doi.org/10.1038/s41591-020-0773-z
Autor:
Luisa E. Brighton, Katherine T. Mills, Jing Zhang, Haibo Zhou, Michelle L. Hernandez, Ilona Jaspers, Milan J. Hazucha, Johnny L. Carson
Publikováno v:
In vitro cellulardevelopmental biology. Animal. 54(3)
The diversity and extent of signaling functions of nitric oxide (NO) in cell physiology as well as its presence and influence as a common component of ambient air pollution and tobacco smoke are gaining increasing research attention relative to both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada130ed7d75cabe17d6825f1efca738
https://pubmed.ncbi.nlm.nih.gov/29380192
https://pubmed.ncbi.nlm.nih.gov/29380192
Autor:
Laura Zhou, Luisa E. Brighton, Haibo Zhou, Katherine H. Mills, Ilona Jaspers, Milan J. Hazucha, Johnny L. Carson
Mucociliary clearance sustains a baseline functionality and an "on demand" capability to upregulate clearance upon irritant exposure involving mucus hypersecretion and accelerated ciliary beat frequency (CBF) modulated by nitric oxide (NO). This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16797034f9c8b1e3a4cce2dcb8967034
Autor:
Kimberlie A. Burns, Maimoona A. Zariwala, Margaret W. Leigh, Adam J. Shapiro, Milan J. Hazucha, Margaret Rosenfeld, Thomas W. Ferkol, Blair V. Robinson, Michael R. Knowles, Sharon D. Dell, Whitney E. Wolf, Kenneth N. Olivier, Johnny L. Carson, Carlos Milla, Scott D. Sagel, Stephanie D. Davis
Publikováno v:
Chest. 146:1176-1186
BACKGROUND Motile cilia dysfunction causes primary ciliary dyskinesia (PCD), situs inversus totalis (SI), and a spectrum of laterality defects, yet the prevalence of laterality defects other than SI in PCD has not been prospectively studied. METHODS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fcf5301c8ac7998764df05b0d4fd266
https://doi.org/10.1378/chest.13-1704
https://doi.org/10.1378/chest.13-1704
Autor:
Hilda M. Metjian, Whitney E. Wolf, Jay Shendure, Michael V. Patrone, Peadar G. Noone, Michael R. Knowles, Hye-Seung Lee, Thomas W. Ferkol, Patrick R. Sears, Martin Kircher, Scott D. Sagel, Jeffrey P. Krischer, Peter J. Noone, Jan Halbritter, Deborah A. Nickerson, Edgar A. Otto, Sharon D. Dell, Lawrence E. Ostrowski, Aruna Sannuti, Friedhelm Hildebrandt, Maimoona A. Zariwala, Margaret Rosenfeld, Hong Dang, Michael J. Bamshad, Scott H. Randell, Kenneth N. Olivier, Johnny L. Carson, Carlos Milla, Christina A. Olson, Milan J. Hazucha, Weining Yin, Stephanie D. Davis, Toby W. Hurd, Heon Yung Gee, Stefan Kohl, Margaret W Leigh
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 189:707-717
Rationale: Primary ciliary dyskinesia (PCD) is a genetically heterogeneous recessive disorder of motile cilia, but the genetic cause is not defined for all patients with PCD. Objectives: To identify disease-causingmutations in novel genes, we perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efe218bd8bc32a3cf02af93b77d661e
https://doi.org/10.1164/rccm.201311-2047oc
https://doi.org/10.1164/rccm.201311-2047oc
Autor:
Whitney E. Wolf, Katrina A. Diaz, Edgar A. Otto, Rim Hjeij, Moumita Chaki, Niki T. Loges, Michael R. Knowles, Petra Pennekamp, Heike Olbrich, Lu Huang, Johanna Raidt, Jan Halbritter, Heon Yung Gee, Heymut Omran, Jay Shendure, Kenneth N. Olivier, Julia Wallmeier, Claudius Werner, Weining Yin, Friedhelm Hildebrandt, Jonathan D. Porath, Michael J. Bamshad, Toby W. Hurd, Matthias Griese, Alexandra P. Lewis, Emily H. Turner, Milan J. Hazucha, Johnny L. Carson, Gerard W. Dougherty, Gyorgy Baktai, Daniela A. Braun, Markus Schueler, Maimoona B Zariwala, Charlotte Jahnke, Thomas W. Ferkol, Sharon D. Dell, Lawrence E. Ostrowski, Margaret W. Leigh, Stephanie D. Davis, Scott D. Sagel, Deborah A. Nickerson
Publikováno v:
The American Journal of Human Genetics. 93:711-720
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous, autosomal-recessive disorder, characterized by oto-sino-pulmonary disease and situs abnormalities. PCD-causing mutations have been identified in 20 genes, but collectively they account
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a033915e0669446098570099be250a9
https://doi.org/10.1016/j.ajhg.2013.07.025
https://doi.org/10.1016/j.ajhg.2013.07.025
Autor:
Ilona Jaspers, Lisa Smeester, Luisa E. Brighton, Rebecca C. Fry, Loretta Müller, Johnny L. Carson, Julia E. Rager, Rebecca N. Bauer
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 305:L432-L438
We previously demonstrated that, in nasal epithelial cells (NECs) from smokers, methylation of an antiviral gene was associated with impaired antiviral defense responses. To expand these findings and better understand biological mechanisms underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3707233d4b1ddbda2b47397a646c2be2
https://doi.org/10.1152/ajplung.00116.2013
https://doi.org/10.1152/ajplung.00116.2013
Autor:
William K. Funkhouser, Marc Niethammer, Johnny L. Carson, W. Keith Funkhouser, Kimberlie A. Burns, Margaret W. Leigh, Maimoona A. Zariwala, Michael R. Knowles
Publikováno v:
Ultrastructural Pathology. 38:248-255
Diagnosis of primary ciliary dyskinesia (PCD) by identification of dynein arm loss in transmission electron microscopy (TEM) images can be confounded by high background noise due to random electron-dense material within the ciliary matrix, leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2dcde50b4a8aff87e18a5ef1c56192
https://doi.org/10.3109/01913123.2013.815081
https://doi.org/10.3109/01913123.2013.815081