A Four-Gene Panel in Rectal Swab Samples as a Biomarker for Colorectal Cancer Screening

Autor: Lui Ng, Sunny Kit-Man Wong, Hung-Sing Li, Ryan Wai-Yan Sin, Johnny Hon-Wai Man, Oswens Siu-Hung Lo, Roberta Wen-Chi Pang, Dominic Chi-Chung Foo, Wai-Lun Law

Publikováno v: Cells, Vol 13, Iss 11, p 930 (2024)

Background: The dysregulation of gene expression is one of the key molecular features of colorectal cancer (CRC) development. This study aimed to investigate whether such dysregulation is reflected in rectal swab specimens of CRC patients and to eval

Externí odkaz: https://doaj.org/article/0007f76b36dc433aa2e1dd36be7fcf54

Prognostic significance of CD26 in patients with colorectal cancer.

Autor: Colin Siu-Chi Lam, Alvin Ho-Kwan Cheung, Sunny Kit-Man Wong, Timothy Ming-Hun Wan, Lui Ng, Ariel Ka-Man Chow, Nathan Shiu-Man Cheng, Ryan Chung-Hei Pak, Hung-Sing Li, Johnny Hon-Wai Man, Thomas Chung-Cheung Yau, Oswens Siu-Hung Lo, Jensen Tung-Chung Poon, Roberta Wen-Chi Pang, Wai Lun Law

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e98582 (2014)

BACKGROUND: CD26, dipeptidyl peptidase IV, was discovered firstly as a membrane-associated peptidase on the surface of leukocyte. We previously demonstrated that a subpopulation of CD26+ cells were associated with the development of distant metastasi

Externí odkaz: https://doaj.org/article/e600298f024a48a8a2aea05e5c6c5433

Small RNA Profiling of piRNAs in Colorectal Cancer Identifies Consistent Overexpression of piR-24000 That Correlates Clinically with an Aggressive Disease Phenotype

Autor: Johnny Hon Wai Man, Timothy Ming-Hun Wan, Dominic Chi-Chung Foo, Lui Ng, Ryan Wai-Yan Sin, Oswens Siu-Hung Lo, Xue Li, Wai Lun Law, Deepak Narayanan Iyer, Roberta Pang

Publikováno v: Cancers
Volume 12
Issue 1
Cancers, Vol 12, Iss 1, p 188 (2020)

Piwi-interacting RNAs (piRNAs) represent a novel class of small non-coding RNAs (ncRNAs) that have been shown to have a deregulated expression in several cancers, although their clinical significance in colorectal cancer (CRC) remains unclear. With a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ddabb250a59119bb550945a2832f80

Osteopontin Overexpression Induced Tumor Progression and Chemoresistance to Oxaliplatin through Induction of Stem-Like Properties in Human Colorectal Cancer

Autor: Thomas Yau, Lui Ng, Chi Chung Foo, Roberta Pang, Johnny Hon Wai Man, Jensen T. C. Poon, Oswens Siu-Hung Lo, Wai Lun Law, Ariel Chow, Guanghua Chen, Deepak Narayanan Iyer, Ronnie Tung-Ping Poon, Timothy Ming-Hun Wan

Publikováno v: Stem Cells International
Stem Cells International, Vol 2015 (2015)

© 2015 Lui Ng et al.Colorectal cancer (CRC) is one of the most common and fatal malignancies worldwide. The poor prognosis of colorectal cancer patients is due to development of chemoresistance and cancer metastasis. Recently osteopontin (OPN) has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f61b3a4321efd6717429e70abce96a3
https://doi.org/10.1155/2015/247892

Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis

Autor: Roberta Pang, Hung-Sing Lee, Wai Lun Law, Ariel K.M. Chow, Lui Ng, Timothy Ming-Hun Wan, Colin S.C. Lam, Johnny Hon Wai Man, Ronnie T.P. Poon, SK Wong, Alvin K.H. Cheung, Deepak Narayanan Iyer

Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 6, p 1106 (2017)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 6; Pages: 1106

Colorectal cancer results from genetic aberrations which accumulate over a long period of time, with malignant and metastatic properties acquired at a relatively late stage. A subpopulation of CD26+ colorectal cancer stem cells are known to be implic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ece9bebf72a98967c8898a3a67bedfc
http://www.mdpi.com/1422-0067/18/6/1106