Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Johnny Castillo-Cabrera"'
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Akademický článek
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC
Autor: Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong
Publikováno v: eLife, Vol 8 (2019)
EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). However, the responses are not durable, and the magnitude of tumor regression is variable, suggesting the existence of genetic modifiers of EGFR dependency. Here, we app
Externí odkaz: https://doaj.org/article/2f4c85fb4b8e4572b5af26dcb106d8f3
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4
Data from TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss
Autor: Qing Zhang, Kan Gong, Albert S. Baldwin, Xianming Tan, Chengheng Liao, Kai Hong, Johnny Castillo Cabrera, Xian Chen, Ling Xie, Laura E. Herring, Emily M. Wilkerson, Lindsey I. James, Frances Potjewyd, Xijuan Liu, Haibiao Xie, Lianxin Hu
TANK binding kinase 1 (TBK1) is an important kinase involved in the innate immune response. Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from patients with kidney cancer with VHL loss
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95c9a565c848d2100f8b2b6302d6c942
https://doi.org/10.1158/2159-8290.c.6547922.v1
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5
AGC Kinase Inhibitors Regulate STING Signaling Through SGK-Dependent and SGK-Independent Mechanisms
Autor: Johnny Castillo Cabrera, Hong Dang, Zhigang Zhang, Jose Torres-Castillo, Kelin Li, Pengda Liu, Jeff Aubé, Blossom Damania, Robert S. Hagan, Albert S. Baldwin
Publikováno v: SSRN Electronic Journal.
The STING signaling pathway is essential for the innate immune response to DNA viruses and bacteria and is important in tumor immunity. STING binding to cGAMP or to synthetic agonists leads to the activation of the kinase TBK1 which phosphorylates th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c16293bf6bf9aaa4d5cc230fa78b7f
https://doi.org/10.2139/ssrn.4190671
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6
TBK1 is a Synthetic Lethal Target in Cancer with VHL Loss
Autor: Albert S. Baldwin, Qing Zhang, Lindsey I. James, Kai Hong, Emily M. Wilkerson, Xian Chen, Johnny Castillo Cabrera, Ling Xie, Haibiao Xie, Xijuan Liu, Kan Gong, Frances Potjewyd, Lianxin Hu, Laura E. Herring, Xianming Tan, Chengheng Liao
Publikováno v: Cancer Discov
TANK binding kinase 1 (TBK1) is an important kinase involved in the innate immune response. Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. Tumors from patients with kidney cancer with VHL loss
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900ccc824a995ec4f0b1c3f980f4a52b
https://europepmc.org/articles/PMC7058506/
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7
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC
Autor: Feng Cong, Bo Lu, Damien Begue, Youzhen Wang, Mika Manser, Alicia Lindeman, John S. Reece-Hoyes, Qiong Wang, Hao Zeng, Xiaomo Jiang, Debora Bonenfant, Carsten Russ, Raffaella Zamponi, Shumei Qiu, Johnny Castillo-Cabrera, Frederic Sigoillot, Vaik Strande, Zinger Yang
Publikováno v: eLife, Vol 8 (2019)
eLife
EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). However, the responses are not durable, and the magnitude of tumor regression is variable, suggesting the existence of genetic modifiers of EGFR dependency. Here, we app
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61abbde7cb9e64212a50ddcb52a3dfb
https://doi.org/10.7554/elife.50223
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