Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node

Autor: Shannon M Walsh, Ryan M Sheridan, Erin D Lucas, Thu A Doan, Brian C Ware, Johnathon Schafer, Rui Fu, Matthew A Burchill, Jay R Hesselberth, Beth Ann Jiron Tamburini

Publikováno v: eLife, Vol 10 (2021)

The detection of foreign antigens in vivo has relied on fluorescent conjugation or indirect read-outs such as antigen presentation. In our studies, we found that these widely used techniques had several technical limitations that have precluded a com

Externí odkaz: https://doaj.org/article/e1a779a5cbfd4b2eb30dfea75847fa35

Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System

Autor: Johnathon Schafer, Anne Tye, Jeffrey M. Finlon, Angelo D'Alessandro, Alyssa R. Goldberg, Rachel H. McMahan, Petra A. Dahms, Rebecca L. McCullough, Andrew B. Winter, Beth A. Jirón Tamburini, Hugo R. Rosen, Michael Kriss, Eric Bohrnsen, Matthew A. Burchill, Julie A. Reisz, Austin E. Gillen, David J. Orlicky

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology

Background and Aims As the incidence of nonalcoholic steatohepatitis (NASH) continues to rise, understanding how normal liver functions are affected during disease is required before developing novel therapeutics which could reduce morbidity and mort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cbc491c1634ab32392b0c20cdd9fbd
https://pubmed.ncbi.nlm.nih.gov/33220266

The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation

Autor: Graça Raposo, Mindaugas Valius, Algirdas Kaupinis, Paulius Gibieža, Ilse Hurbain, Xavier Heiligenstein, Rytis Prekeris, Eric Peterman, Vytenis Arvydas Skeberdis, Johnathon Schafer

Publikováno v: Nature Communications, London : Nature Publishing Group, 2019, vol. 10, no. 1, 3181, p. 981-988
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications

Once thought to be a remnant of cell division, the midbody (MB) has recently been shown to have roles beyond its primary function of orchestrating abscission. Despite the emerging roles of post-abscission MBs, how MBs accumulate in the cytoplasm and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd5b8ba890b1171b34a20b9fd10b872
https://repository.vu.lt/VU:ELABAPDB40514931&prefLang=en_US

PD-L1 reverse signaling in dermal dendritic cells promotes dendritic cell migration required for skin immunity

Autor: Erin D Lucas, Johnathon Schafer, Beth Tamburini

Publikováno v: The Journal of Immunology. 206:11.09-11.09

While the function of the extracellular region of programmed death ligand 1 (PD-L1) through its interactions with PD-1 on T cells is well studied, little is understood regarding signaling via the intracellular domain of PD-L1, termed PD-L1 reverse si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9de65aeacfa1c5dfe6bc981e34e236b9
https://doi.org/10.4049/jimmunol.206.supp.11.09

CD147 Regulates Cell Metabolism in Pancreatic Cancer via Targeting of Multiple Small Molecule Transporters to the Cell Membrane

Autor: Colin D. Weekes, Travis Nemkov, Monika Dzieciatkowska, Elan Z. Eisenmesser, Angelo D’allesandro, Agnieszka A. Kendrick, Joseph Guy, Kirk C. Hansen, Chad G. Pearson, Johnathon Schafer

Publikováno v: Biophysical Journal. 110(3):146a-147a

CD147 is a highly glycosylated type I transmembrane protein upregulated in pancreatic cancer where it has received significant attention as a potential therapeutic target due to its regulation of several proteins that drive cancer progression. While

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37447c40fee768a3f40960e6b6e0adf7