Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Johnathon R. Emlaw"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Ligand-gated ion channels are activated/opened by agonists. Tessier et al. show that agonists can inhibit the inhibition of intrinsic basal activity, and thus that activation may instead be the manifestation of a derepression mechanism.
Externí odkaz:
https://doaj.org/article/e5fa9addcd8a49da8c921ad38b2f143f
Autor:
Christian JG Tessier, Raymond M Sturgeon, Johnathon R Emlaw, Gregory D McCluskey, F Javier Pérez-Areales, Corrie JB daCosta
Publikováno v:
eLife, Vol 11 (2022)
Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from two α-subunits, and one each of the β-, δ-, and ε-subunits. To form functional channels, the subunits must assemble with one another in a precise stoich
Externí odkaz:
https://doaj.org/article/7d82829b541748b58e568c519c9787e2
Agonists are ligands that bind to receptors and activate them. In the case of ligand-gated ion channels, such as the muscle-type nicotinic acetylcholine receptor, mechanisms of agonist activation have been studied for decades. Taking advantage of a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc9bb34649da11b8f995d3675092539
https://doi.org/10.1101/2022.09.13.507804
https://doi.org/10.1101/2022.09.13.507804
Publikováno v:
Biophysical Journal. 122:246a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::968ca08012f172d5f4f0ab9e3dacf7fb
https://doi.org/10.1016/j.bpj.2022.11.1433
https://doi.org/10.1016/j.bpj.2022.11.1433
Autor:
Christian J. G. Tessier, R. Michel Sturgeon, Johnathon R. Emlaw, Gregory D. McCluskey, F. Javier Pérez-Areales, Corrie J. B. daCosta
Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from two α-subunits, and one each of the β-, δ-, and ε-subunits. To form functional channels, the subunits must assemble with one another in a precise stoich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6506b3634d20cd242638f81ed6e9d1ed
https://doi.org/10.1101/2022.01.12.475990
https://doi.org/10.1101/2022.01.12.475990
Autor:
Maria Musgaard, Christian J.G. Tessier, Gregory D. McCluskey, Kelly M. Burkett, Johnathon R. Emlaw, Corrie J.B. daCosta, Melissa McNulty, Yusuf Sheikh
Publikováno v:
Proc Natl Acad Sci U S A
Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from four different, but evolutionarily related, subunits. These subunits assemble with a precise stoichiometry and arrangement such that two chemically distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5042582f4ad9c44e8445e6fbe7e2d842
https://doi.org/10.1073/pnas.2018731118
https://doi.org/10.1073/pnas.2018731118
Publikováno v:
ACS chemical neuroscience. 11(18)
Human adult muscle-type acetylcholine receptors incorporating a reconstructed ancestral β-subunit exhibit reduced single-channel conductance when compared to wild-type. The ancestral and wild-type β-subunits differ by 132 amino acids, including sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1710f470321163db8e7117204d1995cb
https://pubmed.ncbi.nlm.nih.gov/32786311
https://pubmed.ncbi.nlm.nih.gov/32786311
Autor:
Christian J.G. Tessier, F. Javier Pérez-Areales, Johnathon R. Emlaw, Corrie J.B. daCosta, Jean-Paul J. Salameh, Melissa McNulty, Zhuo Qian Cao, Jethro E. Prinston
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1865(11 Pt)
Global functions of nicotinic acetylcholine receptors, such as subunit cooperativity and compatibility, likely emerge from a network of amino acid residues distributed across the entire pentameric complex. Identification of such networks has stymied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2260c3ba8c1e2b7d5af983ad93c555cc
https://pubmed.ncbi.nlm.nih.gov/28844740
https://pubmed.ncbi.nlm.nih.gov/28844740