Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Johnathon N. Lakins"'
Autor:
Connor Stashko, Mary-Kate Hayward, Jason J. Northey, Neil Pearson, Alastair J. Ironside, Johnathon N. Lakins, Roger Oria, Marie-Anne Goyette, Lakyn Mayo, Hege G. Russnes, E. Shelley Hwang, Matthew L. Kutys, Kornelia Polyak, Valerie M. Weaver
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Intratumor heterogeneity associates with poor patient outcome. Stromal stiffening also accompanies cancer. Whether cancers demonstrate stiffness heterogeneity, and if this is linked to tumor cell heterogeneity remains unclear. We developed a
Externí odkaz:
https://doaj.org/article/8eef1f697e6d46898510e81e54f4c1d8
Autor:
Johnathon N. Lakins, Thanh T. Pham, Ori Maller, Irene Acerbi, Andrew C. Nelson, Travis Nemkov, Hellen Kuasne, Allison P. Drain, Olöf Bjarnadottir, Igor Zakharevich, Morag Park, Brian Ruffell, J. Matthew Barnes, Kirk C. Hansen, Aastha Chauhan, E. Shelley Hwang, Valerie M. Weaver, Lisa M. Coussens, Aqsa Nasir, Alexander S. Barrett, Signe Borgquist, Jessica Gruenberg, Tina Gruosso, Peter Kabos, Zena Werb, Yunn Yi Chen
Publikováno v:
Nature materials, vol 20, iss 4
Maller, O, Drain, A P, Barrett, A S, Borgquist, S, Ruffell, B, Zakharevich, I, Pham, T T, Gruosso, T, Kuasne, H, Lakins, J N, Acerbi, I, Barnes, J M, Nemkov, T, Chauhan, A, Gruenberg, J, Nasir, A, Bjarnadottir, O, Werb, Z, Kabos, P, Chen, Y-Y, Hwang, E S, Park, M, Coussens, L M, Nelson, A C, Hansen, K C & Weaver, V M 2021, ' Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression ', Nature Materials, vol. 20, no. 4, pp. 548-559 . https://doi.org/10.1038/s41563-020-00849-5
Nature materials
Maller, O, Drain, A P, Barrett, A S, Borgquist, S, Ruffell, B, Zakharevich, I, Pham, T T, Gruosso, T, Kuasne, H, Lakins, J N, Acerbi, I, Barnes, J M, Nemkov, T, Chauhan, A, Gruenberg, J, Nasir, A, Bjarnadottir, O, Werb, Z, Kabos, P, Chen, Y-Y, Hwang, E S, Park, M, Coussens, L M, Nelson, A C, Hansen, K C & Weaver, V M 2021, ' Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression ', Nature Materials, vol. 20, no. 4, pp. 548-559 . https://doi.org/10.1038/s41563-020-00849-5
Nature materials
Stromal stiffening accompanies malignancy, compromises treatment and promotes tumour aggression. Clarifying the molecular nature and the factors that regulate stromal stiffening in tumours should identify biomarkers to stratify patients for therapy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b763b8a68e3e138bcaa445e6a01a159
https://doi.org/10.1038/s41563-020-00849-5
https://doi.org/10.1038/s41563-020-00849-5
Autor:
Valerie M. Weaver, E. Shelley Hwang, Ori Maller, Xinmiao Yu, Jennifer L. Leight, Hui Zhang, Catherine C. Park, Yunn-Yi Chen, Po-Jui Huang, Jason J. Northey, Brenda P. Alston-Mills, Nastaran Zahir, Johnathon N. Lakins, Allison P. Drain
Publikováno v:
The Journal of experimental medicine, vol 218, iss 5
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Soft extracellular matrix protects breast cancer cells from apoptosis and reduces the efficacy of chemo- and radiation therapies through enhanced NF-κB signaling and diminished proapoptotic JNK activity. Therapeutic targeting of the NF-κB–JNK axi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a0d84f31459646821dcdba2f815b36
https://escholarship.org/uc/item/2pp7k6tz
https://escholarship.org/uc/item/2pp7k6tz
Autor:
Junmin Wu, Po-Jui Huang, Johnathon N. Lakins, Valerie M. Weaver, Jason J. Northey, Quanming Shi, Kirk C. Hansen, Mary-Kate Hayward, Irene Acerbi, Rita A. Mukhtar, Ivory Dean, Jan Liphardt, John A. Shepherd, Alexander S. Barrett, Janna K. Mouw, Susan Samson, Stephanie Talamantes, Laurie E. Littlepage, Yunn-Yi Chen, E. Shelley Hwang, Suzanne M. Ponik, Patricia J. Keely
Publikováno v:
The Journal of clinical investigation, vol 130, iss 11
J Clin Invest
J Clin Invest
Women with dense breasts have an increased lifetime risk of malignancy that has been attributed to a higher epithelial density. Quantitative proteomics, collagen analysis, and mechanical measurements in normal tissue revealed that stroma in the high-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cb2d258f41d9863c029bfabb81cd38
https://escholarship.org/uc/item/4c20x9bw
https://escholarship.org/uc/item/4c20x9bw
Publikováno v:
SSRN Electronic Journal.
Embryogenesis is directed by morphogens that induce differentiation within a defined tissue geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) adhesions and is modulated by cell tension and tissue-level force.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ef7281bb56b3c7b738b57fbef9c77a
https://doi.org/10.2139/ssrn.3543833
https://doi.org/10.2139/ssrn.3543833
Autor:
Jonathon M. Muncie, Valerie M. Weaver, Lydia L. Sohn, Johnathon N. Lakins, Roberto Falcón-Banchs
Publikováno v:
Journal of visualized experiments : JoVE, vol 2019, iss 151
J Vis Exp
J Vis Exp
Human embryonic stem cells demonstrate a unique ability to respond to morphogens in vitro by self-organizing patterns of cell fate specification that correspond to primary germ layer formation during embryogenesis. Thus, these cells represent a power
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636d461ca4c5ee9f6be4ff9b5edd8fb3
https://escholarship.org/uc/item/6r51g9bk
https://escholarship.org/uc/item/6r51g9bk
Autor:
Xufeng Xue, Sajedeh Nasr Esfahani, Valerie M. Weaver, Deborah L. Gumucio, Jianping Fu, Zida Li, Sicong Wang, Jonathon M. Muncie, Johnathon N. Lakins, Yue Shao, Yi Zheng
Publikováno v:
Nature, vol 573, iss 7774
Nature
Nature
Early human embryonic development involves extensive lineage diversification, cell-fate specification and tissue patterning1. Despite its basic and clinical importance, early human embryonic development remains relatively unexplained owing to intersp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785a81707db12689a4ba92b332e06e41
https://escholarship.org/uc/item/8s80g2nh
https://escholarship.org/uc/item/8s80g2nh
Autor:
Valerie M. Weaver, Nadia M. E. Ayad, Xufeng Xue, Johnathon N. Lakins, Jonathon M. Muncie, Jianping Fu
Publikováno v:
Developmental cell, vol 55, iss 6
Dev Cell
Dev Cell
Summary Embryogenesis is directed by morphogens that induce differentiation within a defined tissue geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) adhesions and is modulated by cell tension and tissue-level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6ba497e6fe176703f55f00507e7f61
https://doi.org/10.1016/j.devcel.2020.10.015
https://doi.org/10.1016/j.devcel.2020.10.015
Autor:
Raghu Kalluri, Ryan C. Hill, Valerie M. Weaver, Yekaterina A. Miroshnikova, Grace E. Kim, Eric A. Collisson, Alexander S. Barrett, Valerie S. LeBleu, Kirk C. Hansen, Julia S. Johansen, Valeria Poli, Johnathon N. Lakins, David D. Schlaepfer, Harold L. Moses, Laura D. Wood, Matthias Hebrok, Janna K. Mouw, Michael W. Pickup, Nilotpal Roy, Christine A. Iacobuzio-Donahue, Hanane Laklai, Sergey V. Novitskiy
Publikováno v:
Nature medicine
Laklai, H, Miroshnikova, Y A, Pickup, M W, Collisson, E A, Kim, G E, Barrett, A S, Hill, R C, Lakins, J N, Schlaepfer, D D, Mouw, J K, LeBleu, V S, Roy, N, Novitskiy, S V, Johansen, J S, Poli, V, Kalluri, R, Iacobuzio-Donahue, C A, Wood, L D, Hebrok, M, Hansen, K, Moses, H L & Weaver, V M 2016, ' Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression ', Nature Medicine, vol. 22, no. 5, pp. 497-505 . https://doi.org/10.1038/nm.4082
Laklai, H, Miroshnikova, Y A, Pickup, M W, Collisson, E A, Kim, G E, Barrett, A S, Hill, R C, Lakins, J N, Schlaepfer, D D, Mouw, J K, LeBleu, V S, Roy, N, Novitskiy, S V, Johansen, J S, Poli, V, Kalluri, R, Iacobuzio-Donahue, C A, Wood, L D, Hebrok, M, Hansen, K, Moses, H L & Weaver, V M 2016, ' Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression ', Nature Medicine, vol. 22, no. 5, pp. 497-505 . https://doi.org/10.1038/nm.4082
Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to patient mortality, yet antistromal therapies are controversial. We found that human PDACs with impaired epithelial transforming growth factor-β (TGF-β) signaling h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486cc1c6536bd4b6230b21b45ce4716c
http://europepmc.org/articles/PMC4860133
http://europepmc.org/articles/PMC4860133
Autor:
Shirin Ilkhanizadeh, Christin Schmidt, Trenten Fenster, Dandan Sun, Jason A. Burdick, Jacqueline R Trzeciak, Aurora Irene Idilli, Olle R. Lindberg, Yekaterina A. Miroshnikova, Edith Yuan, Hanna Sabelström, Joanna J. Phillips, Daniele Arosio, Anders Persson, Wen Zhu, William A. Weiss, Valerie M. Weaver, Johnathon N. Lakins, David A. Quigley, Aaron Frantz, Sergey Magnitsky, Supna Saxena, Mitchel S. Berger, Janna K. Mouw
Publikováno v:
Molecular cancer research (Online) 16 (2018): 777–790. doi:10.1158/1541-7786.MCR-17-0413
info:cnr-pdr/source/autori:Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI/titolo:Antisecretory factor-mediated inhibition of cell volume dynamics produces antitumor activity in glioblastoma/doi:10.1158%2F1541-7786.MCR-17-0413/rivista:Molecular cancer research (Online)/anno:2018/pagina_da:777/pagina_a:790/intervallo_pagine:777–790/volume:16
Molecular cancer research : MCR, vol 16, iss 5
info:cnr-pdr/source/autori:Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI/titolo:Antisecretory factor-mediated inhibition of cell volume dynamics produces antitumor activity in glioblastoma/doi:10.1158%2F1541-7786.MCR-17-0413/rivista:Molecular cancer research (Online)/anno:2018/pagina_da:777/pagina_a:790/intervallo_pagine:777–790/volume:16
Molecular cancer research : MCR, vol 16, iss 5
Interstitial fluid pressure (IFP) presents a barrier to drug uptake in solid tumors, including the aggressive primary brain tumor glioblastoma multiforme (GBM). It remains unclear how fluid dynamics impacts tumor progression and can be targeted thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8562a1a297904b86ae6b3f42120db643
http://www.scopus.com/inward/record.url?eid=2-s2.0-85047722544&partnerID=q2rCbXpz
http://www.scopus.com/inward/record.url?eid=2-s2.0-85047722544&partnerID=q2rCbXpz