Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Johnathan Furr"'
Autor:
Leon Earl Gray, Nicola Evans, Christy S. Lambright, Bethany R. Hannas, Justin M. Conley, Johnathan Furr, Hunter Sampson, Vickie S. Wilson, Paul M. D. Foster
Publikováno v:
Toxicol Sci
Previously, we demonstrated that exposure to some diortho-phthalate esters during sexual differentiation disrupts male reproductive development by reducing fetal rat testis testosterone production (T Prod) and gene expression in a dose-related manner
Autor:
Dori R. Germolec, Jennifer Gilliam, Madelyn C Huang, Melanie A Rehder Silinski, Suramya Waidyanatha, Veronica G. Robinson, Johnathan Furr, Helen C. Cunny, Reshan Fernando
Publikováno v:
J Anal Toxicol
Deoxynivalenol (DON) is the most widely distributed trichothecene mycotoxin in grain-based foods and animal feed. Exposure to DON is widespread as it has been detected in food sources from around the world. The objective of this work was to develop a
Autor:
Greg Travlos, Christy S. Lambright, Barry S. McIntyre, Vickie S. Wilson, Brandiese E.J. Beverly, L. Earl Gray, Johnathan Furr, Paul M. D. Foster
Publikováno v:
Toxicol Appl Pharmacol
We showed previously that in utero exposure to the cholesterol-lowering drug simvastatin (SMV) during sex differentiation lowers fetal lipids and testicular testosterone production (T Prod) in Hsd:SD rats. Here, the effects of SMV on fetal lipids and
Autor:
Christy S. Lambright, Phillip C. Hartig, Mary C. Cardon, Nicola Evans, Paul M. D. Foster, Vickie S. Wilson, Leon Earl Gray, Johnathan Furr, Justin M. Conley
Publikováno v:
Toxicological Sciences. 168:632-643
Chemicals that disrupt androgen receptor (AR) function in utero induce a cascade of adverse effects in male rats including reduced anogenital distance, retained nipples, and reproductive tract malformations. The objective of this study was to compare
Autor:
Andrew K. Hotchkiss, Mary C. Cardon, Vickie S. Wilson, Nicola Evans, Phillip C. Hartig, Leon Earl Gray, Johnathan Furr, Christy S. Lambright, Justin M. Conley
Publikováno v:
Toxicol Sci
Multiple molecular initiating events exist that disrupt male sexual differentiation in utero including androgen receptor (AR) antagonism and inhibition of synthesis, and metabolism of fetal testosterone. Disruption of androgen signaling by AR antagon
Autor:
Johnathan Furr, B Collins, Keith R. Shockley, Helen Cunny, Charles D. Hébert, AtLee T. D. Watson, Lori Smith, Lutfiya Miller-Pinsler, Kristin Aillon, Vicki Sutherland, Guanhua Xie, Trey Vinke, Suramya Waidyanatha, Barry S. McIntyre
Publikováno v:
Toxicol Sci
Human exposure to boron occurs primarily through diet and drinking water sources. Animal studies have found that reduced fetal weight following gestational exposure to boron (as boric acid) is the most sensitive toxicological effect. However, recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15eb29ab3dec1006a18db17f44373153
https://europepmc.org/articles/PMC7357175/
https://europepmc.org/articles/PMC7357175/
Autor:
Suramya Waidyanatha, Kristine L. Witt, Madelyn C. Huang, Veronica G. Robinson, Helen Cunny, Dori R. Germolec, Johnathan Furr, Keith R. Shockley, Laura J. Betz
Publikováno v:
Food Chem Toxicol
There is widespread human exposure to deoxynivalenol (DON), a fungal mycotoxin found globally in many grain-based foods and animal feed. Acute exposures to high levels of DON are associated with gastrointestinal effects and emesis in humans and some
Publikováno v:
Toxicological Sciences. 153:382-395
In vitro estrogen receptor assays are valuable tools for identifying environmental samples and chemicals that display estrogenic activity. However, in vitro potency cannot necessarily be extrapolated to estimates of in vivo potency because in vitro a
Autor:
Christy S. Lambright, Nicola Evans, Vickie S. Wilson, Leon Earl Gray, Johnathan Furr, Mary C. Cardon, Justin M. Conley
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 164(1)
Biomonitoring efforts have clearly shown that all humans are exposed to chemical mixtures. Of concern is whether or not exposure to mixtures during pregnancy contributes to congenital abnormalities in children even when each chemical is at an individ
Autor:
L. Earl Gray, Vickie S. Wilson, Johnathan Furr, Barry S. McIntyre, Brandiese E. J. Beverly, Hunter Sampson, Christy S. Lambright, Paul M. D. Foster, Gregory S. Travlos
Publikováno v:
Toxicological Sciences. 141:524-537
Sex differentiation of the male reproductive tract in mammals is driven, in part, by fetal androgen production. In utero, some phthalate esters (PEs) alter fetal Leydig cell differentiation, reducing the expression of several genes associated with st