Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Johnathan C. Buma"'
Autor:
Michelle Herrmann, Brett D. Allison, Alec D. Lebsack, Nadia Swanson, Hong Ao, Johnathan C. Buma, Brian Scott, J. Guy Breitenbucher, Jason C. Rech, Bryan James Branstetter, Alan D. Wickenden, Raymond Rynberg, Michael P. Maher, Sandra R. Chaplan, Anindya Bhattacharya, Lin Luo, Qi Wang, Michele C. Rizzolio, Natalie A. Hawryluk, Jamie M. Freedman, Jeffrey E. Merit
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7142-7146
Based upon a previously reported lead compound 1, a series of 1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines were synthesized and evaluated for improved physiochemical and pharmacokinetic properties while maintaining TRP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0182b4a94e494ac8544ddd208e9dfff8
https://doi.org/10.1016/j.bmcl.2010.09.006
https://doi.org/10.1016/j.bmcl.2010.09.006
Autor:
Frank U. Axe, Johnathan C. Buma, Lars Karlsson, Raymond Rynberg, Michael D. Hack, J. Guy Breitenbucher, Jonathan M. Blevitt, Alice Lee-Dutra, Danielle K. Neff, Anders Brunmark
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(23)
A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82bee811cb903470d3cc8f3d7cf9271
https://pubmed.ncbi.nlm.nih.gov/17937984
https://pubmed.ncbi.nlm.nih.gov/17937984