Výsledky vyhledávání - "JohnB Robbins"

Clostridium difficile Recombinant Toxin A Repeating Units as a Carrier Protein for Conjugate Vaccines: Studies of Pneumococcal Type 14, Escherichia coli K1, and Shigella flexneri Type 2a Polysaccharides in Mice

Autor: David M. Lyerly, Rachel Schneerson, Gerald Schiffman, Danka Pavliakova, Dolores A. Bryla, J S Moncrief, JohnB Robbins

Publikováno v: Infection and Immunity. 68:2161-2166

Unlike the native protein, a nontoxic peptide (repeating unit of the native toxin designated rARU) from Clostridium difficile toxin A (CDTA) afforded an antigen that could be bound covalently to the surface polysaccharides of pneumococcus type 14, Sh

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https://doi.org/10.1128/iai.68.4.2161-2166.2000

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Synthesis, characterization, and immunological properties in mice of conjugates composed of detoxified lipopolysaccharide of Salmonella paratyphi A bound to tetanus toxoid with emphasis on the role of O acetyls

Autor: JohnB Robbins, Joseph Shiloach, Edward Konadu, Dolores A. Bryla, Shousun C. Szu

Publikováno v: Infection and Immunity. 64:2709-2715

Salmonella paratyphi A, the second most common cause of enteric fever in Southeast Asia, is a habitant of and a pathogen for humans only. Lipopolysaccharides (LPS) are both essential virulence factors and protective antigens for systemic infections c

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https://doi.org/10.1128/iai.64.7.2709-2715.1996

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Preparation, characterization, and immunological properties in mice of Escherichia coli O157 O-specific polysaccharide-protein conjugate vaccines

Autor: Shousun C. Szu, Edward Konadu, JohnB Robbins, Dolores A. Bryla, Joseph Shiloach

Publikováno v: Infection and Immunity. 62:5048-5054

Escherichia coli O157 causes severe enteritis and the extraintestinal complication of hemolytic-uremic syndrome, with their highest incidence occurring in children. We postulated that serum immunoglobulin G (IgG) antibodies to the O-specific polysacc

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https://doi.org/10.1128/iai.62.11.5048-5054.1994

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Laboratory and preliminary clinical characterization of Vi capsular polysaccharide-protein conjugate vaccines

Autor: J D Clements, D N Taylor, Joseph Shiloach, JohnB Robbins, A C Trofa, J C Sadoff, Dolores A. Bryla, Shousun C. Szu

Publikováno v: Infection and Immunity. 62:4440-4444

To improve its immunogenicity for children and adults and to make it suitable for routine immunization of infants against typhoid fever, the capsular polysaccharide of Salmonella typhi (Vi) was bound to the B subunit of the heat-labile toxin (LT-B) o

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https://doi.org/10.1128/iai.62.10.4440-4444.1994

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Laboratory and clinical evaluation of conjugate vaccines composed of Staphylococcus aureus type 5 and type 8 capsular polysaccharides bound to Pseudomonas aeruginosa recombinant exoprotein A

Autor: Ira Pastan, Dolores A. Bryla, R Schneerson, David J. FitzGerald, W W Karakawa, JohnB Robbins, A. Fattom, Douglas Watson, Xiuru Li, Joseph Shiloach

Publikováno v: Infection and Immunity. 61:1023-1032

The synthesis, standardization, and immunogenicity in young outbred mice and clinical evaluation in adult volunteers of investigational vaccines designed to induce serum antibodies to the type 5 and type 8 capsular polysaccharides (CPs) of Staphyloco

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https://doi.org/10.1128/iai.61.3.1023-1032.1993

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Protection of mice against Salmonella typhimurium with an O-specific polysaccharide-protein conjugate vaccine

Autor: Douglas Watson, JohnB Robbins, Shousun C. Szu

Publikováno v: Infection and Immunity. 60:4679-4686

Serious infections with salmonellae remain a threat in many human populations. Despite extensive study of salmonella infections in animals and clinical experience with killed cellular vaccines, there are no vaccines against serotypes other than Salmo

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https://doi.org/10.1128/iai.60.11.4679-4686.1992

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Synthesis of a conjugate vaccine composed of pneumococcus type 14 capsular polysaccharide bound to pertussis toxin

Autor: Rachel Schneerson, D M Bryla, Teresa Lagergård, G Schiffman, JohnB Robbins, L Levi

Publikováno v: Infection and Immunity. 60:3528-3532

Type 14 is one of the common types isolated from patients of all ages with infections caused by Streptococcus pneumoniae. Its capsular polysaccharide (Pn14) is composed of a neutrally charged tetrasaccharide repeat unit. Pn14 does not elicit protecti

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https://doi.org/10.1128/iai.60.9.3528-3532.1992

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Comparative immunogenicity of conjugates composed of the Staphylococcus aureus type 8 capsular polysaccharide bound to carrier proteins by adipic acid dihydrazide or N-succinimidyl-3-(2-pyridyldithio)propionate

Autor: David J. FitzGerald, Joseph Shiloach, R Schneerson, A. Fattom, Ira Pastan, Dolores A. Bryla, W W Karakawa, JohnB Robbins

Publikováno v: Infection and Immunity. 60:584-589

Staphylococcus aureus type 8 capsular polysaccharide (CP) was conjugated either to diphtheria toxoid or to Pseudomonas aeruginosa recombinant exoprotein A by using adipic acid dihydrazide (ADH) or N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP) a

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https://doi.org/10.1128/iai.60.2.584-589.1992

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Preparation, characterization, and immunogenicity of conjugates composed of the O-specific polysaccharide of Shigella dysenteriae type 1 (Shiga's bacillus) bound to tetanus toxoid

Autor: Joseph Shiloach, Chiayung Chu, Rachel Schneerson, S S Szu, JohnB Robbins, Dolores A. Bryla, B K Liu, Douglas Watson

Publikováno v: Infection and Immunity. 59:4450-4458

The background for developing conjugate vaccines for shigellosis composed of the O-specific polysaccharide (O-SP) bound to a protein is described elsewhere (C. Y. Chu, R. Schneerson, and J. B. Robbins, submitted for publication). Briefly, there is di

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https://doi.org/10.1128/iai.59.12.4450-4458.1991

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Synthesis and immunologic properties in mice of vaccines composed of Staphylococcus aureus type 5 and type 8 capsular polysaccharides conjugated to Pseudomonas aeruginosa exotoxin A

Autor: Rachel Schneerson, Joseph Shiloach, JohnB Robbins, W W Karakawa, A Fattom, Shousun C. Szu, W. F. Vann

Publikováno v: Infection and Immunity. 58:2367-2374

Epidemiological, serological and in vitro phagocytosis experiments provide evidence that the newly discovered type 5 and type 8 capsular polysaccharides (CPs) are both virulence factors and protective antigens for bacteremia caused by Staphylococcus

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https://doi.org/10.1128/iai.58.7.2367-2374.1990

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