Zobrazeno 1 - 10
of 184
pro vyhledávání: '"John. E. Pintar"'
Autor:
Srijita Bhowmik, Juraj Galeta, Václav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Mike Ansonoff, Tomas Fiala, Amanda Hunkele, Andrew C. Kruegel, John. E. Pintar, Susruta Majumdar, Jonathan A. Javitch, Dalibor Sames
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mitragynine (MG) is an indole alkaloid from kratom plant that binds opioid receptors and as such presents a scaffold for the development of atypical opioid receptor modulators. Here, the authors report a synthetic method for selective functionalizati
Externí odkaz:
https://doaj.org/article/ea38af09c9b14aa088b91f729a3dae52
Autor:
Elena Carazo-Arias, Phi T. Nguyen, Marley Kass, Hyun Jung Jee, Katherine M. Nautiyal, Valerie Magalong, Lilian Coie, Valentine Andreu, Mark M. Gergues, Huzefa Khalil, Huda Akil, Danusa Mar Arcego, Michael Meaney, Christoph Anacker, Benjamin A. Samuels, John E. Pintar, Irina Morozova, Sergey Kalachikov, Rene Hen
Publikováno v:
Biological Psychiatry. 92:952-963
Autor:
Bronwyn M. Kivell, Shainnel O. Eans, Abdullah Allaoa, András Váradi, Lisa L. Wilson, Gavril W. Pasternak, Rajendra Uprety, Andrew C. Kruegel, John E. Pintar, Xiaohai Li, Samuel T. Slocum, Takeshi Irie, Jay P. McLaughlin, Brittany Scouller, Amy F. Alder, Michael D. Cameron, Sanjay Kalra, Ying-Xian Pan, Amanda Hunkele, Susruta Majumdar, Michael Ansonoff, Valerie Le Rouzic, Dalibor Sames, Soumen Chakraborty, Jin Xu
Publikováno v:
J Med Chem
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacolo
Autor:
Lakshmi A. Devi, John E. Pintar, Dinah L. Ramos-Ortolaza, Hui Pan, Malcom J. Low, Ivone Gomes, Michael D. Hayward, Achla Gupta, Srinivas Gullapalli
Publikováno v:
Cell Mol Neurobiol
Activation of μ, δ, and κ opioid receptors by endogenous opioid peptides leads to the regulation of many emotional and physiological responses. The three major endogenous opioid peptides, β-endorphin, enkephalins, and dynorphins result from the p
Autor:
Abdelfattah Faouzi, Hye Jean Yoon, Rajendra Uprety, John M. Streicher, Lakshmi A. Devi, Susruta Majumdar, Michael Ansonoff, Ivone Gomes, Nicolas Massaly, Tiffany Zhang, Valerie Le Rouzic, Attila Keresztes, Jose A. Morón, Ying-Xian Pan, Achla Gupta, Abdullah Allaoa, John E. Pintar
Publikováno v:
J Med Chem
In this work, we studied a series of carfentanyl amide-based opioid derivatives targeting the mu opioid receptor (μOR) and the delta opioid receptor (δOR) heteromer as a credible novel target in pain management therapy. We identified a lead compoun
Autor:
Philip S. Portoghese, George L. Wilcox, Daniel J. Bruce, Michael Ansonoff, Defeng Tian, Eyup Akgün, Mary M. Lunzer, John E. Pintar, Jon E. Hawkinson
Publikováno v:
Biochemistry. 60:1413-1419
This report describes the unique pharmacological profile of FBNTI, a potent DOR antagonist that acts as a MOR agonist via an allosteric mechanism. Binding of FBNTI to opioid receptors expressed in HEK 293 cells revealed a 190-fold greater affinity fo
Autor:
John E. Pintar, Brigitte L. Kieffer, Cory Langreck, Elizabeth A. Pekarskaya, Alexander Z. Harris, Steven G. Grinnell, Katherine M. Nautiyal, Florence Allain, Jaena Han, Valerie M. Magalong, Valentine Andreu, Jonathan A. Javitch, René Hen
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021, ⟨10.1038/s41386-021-01192-2⟩
Neuropsychopharmacology
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021, ⟨10.1038/s41386-021-01192-2⟩
Neuropsychopharmacology
Tianeptine is an atypical antidepressant used in Europe to treat patients who respond poorly to selective serotonin reuptake inhibitors (SSRIs). The recent discovery that tianeptine is a mu opioid receptor (MOR) agonist has provided a potential avenu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f43c2ef1072141f27ceffaf631c574
https://hal.archives-ouvertes.fr/hal-03408174
https://hal.archives-ouvertes.fr/hal-03408174
Autor:
Leia Stallings, Dalibor Sames, Saheem A. Zaidi, Mike Ansonoff, Mu Yang, Andrew C. Kruegel, John E. Pintar, Madalee G. Wulf, Susruta Majumdar, Scott E. Hemby, Scot McIntosh, Alana Hodges, Najah Abi-Gerges, Amanda Hunkele, Melissa Nelson, Benjamin Bechand, Christopher Hwu, Vsevolod Katritch, Vaclav Havel, Jonathan A. Javitch
Substance use and related mental health epidemics are causing increasing suffering and death in diverse communities.1,2Despite extensive efforts focused on developing pharmacotherapies for treating substance use disorders, there is an urgent need for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa5fecd29440dbb1136a7e1684958343
https://doi.org/10.1101/2021.07.22.453441
https://doi.org/10.1101/2021.07.22.453441
Autor:
John E. Pintar, Andrew C. Kruegel, Gavril W. Pasternak, Jonathan A. Javitch, Steven G. Grinnell, Madalee M. Gassaway, Dalibor Sames, Rajendra Uprety, Elizabeth A. Pekarskaya, Valerie Le Rouzic, Susruta Majumdar, Michael Ansonoff, Cory Langreck
Publikováno v:
ACS Central Science, Vol 5, Iss 6, Pp 992-1001 (2019)
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction. Recently, growing use of the plant in the United
Autor:
Abdelfattah Faouzi, Benjamin Bechand, Susruta Majumdar, Jonathan A. Javitch, Andrew C. Kruegel, Juraj Galeta, Tomas Fiala, Srijita Bhowmik, Vaclav Havel, Dalibor Sames, Mike Ansonoff, John E. Pintar, Amanda Hunkele, Melissa Nelson
Publikováno v:
Nature Communications
Nature Communications, 12 (1)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, 12 (1)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mitragynine (MG) is the most abundant alkaloid component of the psychoactive plant material “kratom”, which according to numerous anecdotal reports shows efficacy in self-medication for pain syndromes, depression, anxiety, and substance use disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9de81b7aacd8b411234961746c5ac2e