Zobrazeno 1 - 10
of 86
pro vyhledávání: '"John-Demian Sauer"'
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109532- (2024)
Summary: Wound healing is impaired by infection; however, how microbe-induced inflammation modulates tissue repair remains unclear. We took advantage of the optical transparency of zebrafish and a genetically tractable microbe, Listeria monocytogenes
Externí odkaz:
https://doaj.org/article/1f7e2c76438f40779d2cde0cb1d6f736
Autor:
Daniel A. Pensinger, Kimberly V. Gutierrez, Hans B. Smith, William J. B. Vincent, David S. Stevenson, Katherine A. Black, Krizia M. Perez-Medina, Joseph P. Dillard, Kyu Y. Rhee, Daniel Amador-Noguez, TuAnh N. Huynh, John-Demian Sauer
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT The cytosol of eukaryotic host cells is an intrinsically hostile environment for bacteria. Understanding how cytosolic pathogens adapt to and survive in the cytosol is critical to developing novel therapeutic interventions against these path
Externí odkaz:
https://doaj.org/article/88684de585724f3481c9077b882de580
Autor:
Rafael Rivera-Lugo, David Deng, Andrea Anaya-Sanchez, Sara Tejedor-Sanz, Eugene Tang, Valeria M Reyes Ruiz, Hans B Smith, Denis V Titov, John-Demian Sauer, Eric P Skaar, Caroline M Ajo-Franklin, Daniel A Portnoy, Samuel H Light
Publikováno v:
eLife, Vol 11 (2022)
Cellular respiration is essential for multiple bacterial pathogens and a validated antibiotic target. In addition to driving oxidative phosphorylation, bacterial respiration has a variety of ancillary functions that obscure its contribution to pathog
Externí odkaz:
https://doaj.org/article/b9b31cc173164b79bceb720e420b9aca
Autor:
Travis G. Wentz, Benjamin J. M. Tremblay, Marite Bradshaw, Andrew C. Doxey, Shashi K. Sharma, John-Demian Sauer, Sabine Pellett
Publikováno v:
Frontiers in Microbiology, Vol 12 (2022)
Most strains of proteolytic group I Clostridium botulinum (G1 C. botulinum) and some strains of Clostridium sporogenes possess genes encoding botulinum neurotoxin (BoNT), a potent neuroparalytic agent. Within G1 C. botulinum, conserved bont gene clus
Externí odkaz:
https://doaj.org/article/e8e6b4bfe40c486c95c0c56b7f179047
Autor:
Veronika Miskolci, Kelsey E Tweed, Michael R Lasarev, Emily C Britt, Alex J Walsh, Landon J Zimmerman, Courtney E McDougal, Mark R Cronan, Jing Fan, John-Demian Sauer, Melissa C Skala, Anna Huttenlocher
Publikováno v:
eLife, Vol 11 (2022)
The function of macrophages in vitro is linked to their metabolic rewiring. However, macrophage metabolism remains poorly characterized in situ. Here, we used two-photon intensity and lifetime imaging of autofluorescent metabolic coenzymes, nicotinam
Externí odkaz:
https://doaj.org/article/8206c968188744b0808bd43cb3275c27
Autor:
Zachary Morrow, John-Demian Sauer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/dfe57b779ae248cfbe41a7c3bb3d6dd6
Autor:
Jessica L Kelliher, Caroline M Grunenwald, Rhiannon R Abrahams, McKenzie E Daanen, Cassandra I Lew, Warren E Rose, John-Demian Sauer
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009881 (2021)
Pathogenic bacteria rely on protein phosphorylation to adapt quickly to stress, including that imposed by the host during infection. Penicillin-binding protein and serine/threonine-associated (PASTA) kinases are signal transduction systems that sense
Externí odkaz:
https://doaj.org/article/fb8a1d14f47a4375b9c8dcb89d97cf49
Autor:
Courtney E McDougal, Zachary T Morrow, Tighe Christopher, Seonyoung Kim, Drake Carter, David M Stevenson, Daniel Amador-Noguez, Mark J Miller, John-Demian Sauer
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009493 (2021)
Listeria monocytogenes is an intracellular bacterium that elicits robust CD8+ T-cell responses. Despite the ongoing development of L. monocytogenes-based platforms as cancer vaccines, our understanding of how L. monocytogenes drives robust CD8+ T-cel
Externí odkaz:
https://doaj.org/article/70d5aed845d64ce69478e83c864f8843
Autor:
Woojong Lee, Brock Kingstad-Bakke, Brett Paulson, Autumn Larsen, Katherine Overmyer, Chandranaik B Marinaik, Kelly Dulli, Randall Toy, Gabriela Vogel, Katherine P Mueller, Kelsey Tweed, Alex J Walsh, Jason Russell, Krishanu Saha, Leticia Reyes, Melissa C Skala, John-Demian Sauer, Dmitry M Shayakhmetov, Joshua Coon, Krishnendu Roy, M Suresh
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009168 (2021)
There is a critical need for adjuvants that can safely elicit potent and durable T cell-based immunity to intracellular pathogens. Here, we report that parenteral vaccination with a carbomer-based adjuvant, Adjuplex (ADJ), stimulated robust CD8 T-cel
Externí odkaz:
https://doaj.org/article/73580a7e1e6e47af817c8a1751850e37
Autor:
Laura C. Ristow, Vy Tran, Kevin J. Schwartz, Lillie Pankratz, Andrew Mehle, John-Demian Sauer, Rodney A. Welch
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT The Escherichia coli hemolysin (HlyA) is a pore-forming exotoxin associated with severe complications of human urinary tract infections. HlyA is the prototype of the repeats-in-toxin (RTX) family, which includes LtxA from Aggregatibacter act
Externí odkaz:
https://doaj.org/article/07258d37f51446f99ca294545c1ad19d