Zobrazeno 1 - 10
of 73
pro vyhledávání: '"John van Noort"'
Autor:
Nikolay Korolev, Anatoly Zinchenko, Aghil Soman, Qinming Chen, Sook Yi Wong, Nikolay V. Berezhnoy, Rajib Basak, Johan R. C. van der Maarel, John van Noort, Lars Nordenskiöld
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Large topologically associated domains (TADs) contain irregularly spaced nucleosome clutches, and interactions between such clutches are thought to aid the compaction of these domains. Here, we reconstituted TAD-sized chromatin fibers contai
Externí odkaz:
https://doaj.org/article/84b90e5eb555443c8b883fe2cdd2d51f
Autor:
Radoslaw J. Gora, Babette de Jong, Patrick van Hage, Mary Ann Rhiemus, Fjodor van Steenis, John van Noort, Thomas Schmidt, Marcel J. M. Schaaf
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 2 (2022)
Developments in single-molecule microscopy (SMM) have enabled imaging individual proteins in biological systems, focusing on the analysis of protein mobility patterns inside cultured cells. In the present study, SMM was applied in vivo, using the zeb
Externí odkaz:
https://doaj.org/article/5a8fe60d05744d6085ec13db31dfaf8a
Autor:
Gabriela Arias-Alpizar, Li Kong, Redmar C. Vlieg, Alexander Rabe, Panagiota Papadopoulou, Michael S. Meijer, Sylvestre Bonnet, Stefan Vogel, John van Noort, Alexander Kros, Frederick Campbell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Surface charge plays an important role in determining nanoparticle fate in vivo. Here the authors report on the development of a light triggered charge switching liposome and demonstrate light triggered liposome targeting, uptake and payload delivery
Externí odkaz:
https://doaj.org/article/1063984a1283454ca28a151ef6983122
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Torsional stress is generated during DNA replication and transcription, however, the propagation of twist in condensed chromatin is poorly understood. Here the authors measure how force and torque impact chromatin fibers and find that the fibers fold
Externí odkaz:
https://doaj.org/article/30a70ffb95644882808b1311d671a36e
Autor:
Babette E de Jong, John van Noort
Publikováno v:
eLife, Vol 8 (2019)
Single-molecule experiments reveal the dynamics of transcription through a nucleosome with single-base-pair accuracy.
Externí odkaz:
https://doaj.org/article/e91f811724444f1eb7fcff8f1fc23c4c
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156905 (2016)
Eukaryotic DNA is strongly bent inside fundamental packaging units: the nucleosomes. It is known that their positions are strongly influenced by the mechanical properties of the underlying DNA sequence. Here we discuss the possibility that these mech
Externí odkaz:
https://doaj.org/article/9d91d39fe1994feaba1cebd3e23f7e1c
Autor:
Joke J F A van Vugt, Martijn de Jager, Magdalena Murawska, Alexander Brehm, John van Noort, Colin Logie
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6345 (2009)
BACKGROUND:Chromosome structure, DNA metabolic processes and cell type identity can all be affected by changing the positions of nucleosomes along chromosomal DNA, a reaction that is catalysed by SNF2-type ATP-driven chromatin remodelers. Recently it
Externí odkaz:
https://doaj.org/article/5318f6c9382d4f45b318d017e4d843e6
Autor:
Aghil Soman, Sook Yi Wong, Nikolay Korolev, Wahyu Surya, Simon Lattman, Vinod K. Vogirala, Qinming Chen, Nikolay V. Berezhnoy, John van Noort, Daniela Rhodes, Lars Nordenskiöld
Telomeres, the ends of eukaryotic chromosomes, play pivotal roles in ageing and cancer and are targets of DNA damage and response. However, little is known about the structure and organization of telomeric chromatin at the molecular level. We used el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fe8da5a2219798f921aa6c45eb40c03
https://doi.org/10.1101/2022.06.15.496090
https://doi.org/10.1101/2022.06.15.496090
Autor:
Redmar C. Vlieg, John van Noort
Publikováno v:
The Journal of Chemical Physics, 156
Plasmonic metallic nanoparticles are commonly used in (bio-)sensing applications because their localized surface plasmon resonance is highly sensitive to changes in the environment. Although optical detection of scattered light from single particles
Autor:
Elena A, Egorova, Gabriela, Arias-Alpizar, Redmar C, Vlieg, Gert S, Gooris, Joke A, Bouwstra, John van, Noort, Alexander, Kros, Aimee L, Boyle
Publikováno v:
Journal of materials chemistry. B. 10(10)
Gold nanorods (GNRs) are versatile asymmetric nanoparticles with unique optical properties. These properties make GNRs ideal agents for applications such as photothermal cancer therapy, biosensing, and