Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John Y L Chiang"'
Autor:
Dipanjan Chanda, Yong-Hoon Kim, Tiangang Li, Jagannath Misra, Don-Kyu Kim, Jung Ran Kim, Joseph Kwon, Won-Il Jeong, Sung-Hoon Ahn, Tae-Sik Park, Seung-Hoi Koo, John Y L Chiang, Chul-Ho Lee, Hueng-Sik Choi
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68845 (2013)
Bile acids concentration in liver is tightly regulated to prevent cell damage. Previous studies have demonstrated that deregulation of bile acid homeostasis can lead to cholestatic liver disease. Recently, we have shown that ER-bound transcription fa
Externí odkaz:
https://doaj.org/article/bbd54b9e0aa64dd0b96b06b9da7d7b41
Autor:
Bandar D. Alrehaili, Mikang Lee, Shogo Takahashi, Robert Novak, Bipin Rimal, Shannon Boehme, Samuel A. J. Trammell, Trisha J. Grevengoed, Devendra Kumar, Yazen Alnouti, Katya Chiti, Xinwen Wang, Andrew D. Patterson, John Y. L. Chiang, Frank J. Gonzalez, Yoon‐Kwang Lee
Publikováno v:
Hepatology Communications, Vol 6, Iss 10, Pp 2765-2780 (2022)
Abstract Bile acid‐CoA: amino acid N‐acyltransferase (BAAT) catalyzes bile acid conjugation, the last step in bile acid synthesis. BAAT gene mutation in humans results in hypercholanemia, growth retardation, and fat‐soluble vitamin insufficienc
Externí odkaz:
https://doaj.org/article/d79211ba0cd04455982000fdada5d57f
Publikováno v:
Cardiology Plus, Vol 5, Iss 4, Pp 159-170 (2020)
Dysregulation of lipid metabolism is a major factor contributing to atherosclerotic cardiovascular disease (ACVD), which is the number one cause of death in western countries. The liver plays a central role in maintaining whole body cholesterol homeo
Externí odkaz:
https://doaj.org/article/5662aa19d3eb42499b54a8c7b6422afb
Autor:
Ge Gao, Tao Zheng, Beidi Lan, Weiying Hui, Shi Chen, Zuyi Yuan, Yue Wu, John Y. L. Chiang, Tao Chen
Publikováno v:
Cardiology Plus. 8:46-52
Autor:
Jessica M. Ferrell, Matthew Dilts, Zachary Stahl, Sabita Pokhrel, Shannon Boehme, John Y. L. Chiang
Publikováno v:
The FASEB Journal. 36
Autor:
Xiaohua, Guo, Edozie Samuel, Okpara, Wanting, Hu, Chuyun, Yan, Yu, Wang, Qionglin, Liang, John Y L, Chiang, Shuxin, Han
Publikováno v:
International Journal of Molecular Sciences. 23:8343
The digestive tract is replete with complex and diverse microbial communities that are important for the regulation of multiple pathophysiological processes in humans and animals, particularly those involved in the maintenance of intestinal homeostas
Autor:
John Y. L. Chiang
Publikováno v:
Hepatology Communications
Autor:
Tiangang, Li, Jessica M, Francl, Shannon, Boehme, Adrian, Ochoa, Youcai, Zhang, Curtis D, Klaassen, Sandra K, Erickson, John Y L, Chiang
Publikováno v:
The Journal of biological chemistry. 287(3)
Bile acids facilitate postprandial absorption of nutrients. Bile acids also activate the farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5 and play a major role in regulating lipid, glucose, and energy metabolism. Transgenic expressi
Publikováno v:
The Journal of biological chemistry. 281(39)
Bile acid synthesis and pool size increases in diabetes, whereas insulin inhibits bile acid synthesis. The objective of this study is to elucidate the mechanism of insulin regulation of cholesterol 7alpha-hydroxylase gene expression in human hepatocy
Autor:
John Y L, Chiang
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 6(10)
Lipids are essential components of biological membranes, fuel molecules and metabolic regulators that control cellular functions, metabolism and homeostasis. The liver plays a central role in regulating lipid metabolism and whole body lipid homeostas