Zobrazeno 1 - 10
of 147
pro vyhledávání: '"John X. Wilson"'
Autor:
Guowei Huang, Zhenshu Li, Ling Huang, Wen Li, Cuixia Dong, Yue Ma, Jing Zhao, Dezheng Zhou, John X. Wilson
Publikováno v:
Molecular Neurobiology. 59:590-602
DNA oxidative damage can cause telomere attrition or dysfunction that triggers cell senescence and apoptosis. The hypothesis of this study is that folic acid decreases apoptosis in neural stem cells (NSCs) by preventing oxidative stress-induced telom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0db674cf804a6ae98672f699dcc20d
https://doi.org/10.1007/s12035-021-02623-3
https://doi.org/10.1007/s12035-021-02623-3
Autor:
Yalan Wang, Wen Li, Hong Chang, Guowei Huang, Dezheng Zhou, Xinyan Wang, John X. Wilson, Xin Lv
Publikováno v:
Aging (Albany NY)
The occurrence of telomere attrition in brain may cause senescence and death of neurons, leading to cognitive decline. Folic acid (FA) has been reported to improve cognitive performance in mild cognitive impairment; however, its association with telo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9137208846586b49306318c176d7e228
https://doi.org/10.18632/aging.102461
https://doi.org/10.18632/aging.102461
Autor:
Yongjie Chen, John X. Wilson, Guowei Huang, Zhiyong Qian, Jing Zhao, Dezheng Zhou, Dalong Zhang, Yue Sun, Huan Liu, Zhenshu Li, Wen Li
Publikováno v:
Cerebral cortex (New York, N.Y. : 1991). 32(2)
Folic acid (FA) has been reported to inhibit astrocyte apoptosis and improve aging-induced disorders; however, its role in telomere attrition remains unclear. In present study, 4-month-old senescence-accelerated mouse prone 8 (SAMP8) mice were assign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d138615674036fcc251a44b4a94b1dda
https://pubmed.ncbi.nlm.nih.gov/34223882
https://pubmed.ncbi.nlm.nih.gov/34223882
Publikováno v:
Molecular Neurobiology. 55:2676-2684
Maternal folate status during pregnancy may influence central nervous system (CNS) development in offspring. However, the recommended intakes of folic acid for women of childbearing age differ among countries and there is still no consensus about whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc584d1ef472675685ffdb9ce741557c
https://doi.org/10.1007/s12035-017-0534-2
https://doi.org/10.1007/s12035-017-0534-2
Autor:
Yue Ma, Xinyan Wang, Zhenshu Li, Suhui Luo, Wen Li, Guowei Huang, John X. Wilson, Dezheng Zhou, Xin Lv
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 1
Volume 21
Issue 1
Astrocytes are the most widely distributed cells in the brain, and astrocyte apoptosis may play an important role in the pathogenesis of neurodegenerative diseases. Folate is required for the normal development of the nervous system, but its effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b41c52b8a7eee1f0e374b5b484b4e13
https://pubmed.ncbi.nlm.nih.gov/31861819
https://pubmed.ncbi.nlm.nih.gov/31861819
Publikováno v:
Cerebral cortex (New York, N.Y. : 1991). 29(8)
Maternal folic acid supplementation during pregnancy is associated with improved cognitive performances in offspring. However, the effect of supplementation on offspring’s neurogenesis and synaptogenesis is unknown, and whether supplementation shou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9086fd3d803f090299322bab4a3cf49e
https://pubmed.ncbi.nlm.nih.gov/30137237
https://pubmed.ncbi.nlm.nih.gov/30137237
Publikováno v:
Nutrients
Nutrients; Volume 10; Issue 3; Pages: 292
Nutrients, Vol 10, Iss 3, p 292 (2018)
Nutrients; Volume 10; Issue 3; Pages: 292
Nutrients, Vol 10, Iss 3, p 292 (2018)
Periconceptional maternal folate levels may alter DNA methylation patterns and health outcomes in offspring. We hypothesized that maternal folic acid supplementation alters fetal neural development through DNA methylation in the fetal brain. Twenty-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a69233239668954eb5c00a59a1214a0
https://pubmed.ncbi.nlm.nih.gov/29494536
https://pubmed.ncbi.nlm.nih.gov/29494536
Publikováno v:
Molecular Neurobiology. 53:6548-6556
Dementia has emerged as a major societal issue because of the worldwide aging population and the absence of any effective treatment. DNA methylation is an epigenetic mechanism that evidently plays a role in Alzheimer's disease (AD). Folate acts throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ed9b8f58ce2ced0c26fe565e8b10b7
https://doi.org/10.1007/s12035-015-9556-9
https://doi.org/10.1007/s12035-015-9556-9
Autor:
Yanyu Xiao, Guowei Huang, Huan Liu, John X. Wilson, Shijing Zhao, Xumei Zhang, Meilin Zhang, Wen Li
Publikováno v:
European Journal of Nutrition. 55:1849-1862
Alzheimer’s disease (AD) is a highly prevalent type of dementia. The epigenetic mechanism of gene methylation provides a putative link between nutrition, one-carbon metabolism, and disease progression because folate deficiency may cause hypomethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d691e6f05b6f5a5cf3c64d5be8c594
https://doi.org/10.1007/s00394-015-1002-2
https://doi.org/10.1007/s00394-015-1002-2
Publikováno v:
The Journal of Nutritional Biochemistry. 24:1295-1301
The proliferative response of neural stem cells (NSCs) to folate may play a critical role in the development, function and repair of the central nervous system. It is important to determine the dose-dependent effects of folate in NSC cultures that ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa70922dacfc1c546c673f373769ffd
https://doi.org/10.1016/j.jnutbio.2012.11.001
https://doi.org/10.1016/j.jnutbio.2012.11.001