Zobrazeno 1 - 10
of 17
pro vyhledávání: '"John Woolfrey"'
Autor:
Douglas A. Corley, Dan Li, Wei K. Zhao, Mary Anne Armstrong, Christopher D. Jensen, Sanjay Kakar, Debbie Postlethwaite, Greg Rumore, Theodore R. Levin, Monica Santamaria, John Woolfrey, Sheng-Fang Jiang
Publikováno v:
Gastrointestinal endoscopy. 87(3)
Background and Aims Sessile serrated adenomas (SSAs) are precursors of 15% to 30% of colorectal cancers but are frequently underdiagnosed. We sought to measure the SSA detection rate (SDR) and predictors of SSA detection after educational training fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796eddceea32203a4ffedbdc13743843
https://pubmed.ncbi.nlm.nih.gov/28843582
https://pubmed.ncbi.nlm.nih.gov/28843582
Autor:
John Woolfrey, Craig Stacy Takeuchi, Arthur Plonowski, Kyoko Yamaguchi, Ron Aoyama, Byung Gyu Kim, Anagha Abhijit Joshi, Paul Foster, Sunghoon Ma, Sharmila Rajan, Tae Gon Baik, Naing Aay, Arlyn Arcalas, Charles M. Blazey, Jonah Cannoy, Peter Lamb, Isabelle Lehoux, Chris A. Buhr, Narsimha Munagala, Matthew Sangyup Lee, John M. Nuss, James W. Leahy, Jae Lee, Sergey Epshteyn, Neel Kumar Anand, Nicole Miller, Longcheng Wang, Katherine Lara, Henry Johnson
Publikováno v:
Journal of Medicinal Chemistry. 56:2218-2234
A series of novel, highly potent, selective, and ATP-competitive mammalian target of rapamycin (mTOR) inhibitors based on a benzoxazepine scaffold have been identified. Lead optimization resulted in the discovery of inhibitors with low nanomolar acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37d108d9c419238d27ed27c967013b5
https://doi.org/10.1021/jm3007933
https://doi.org/10.1021/jm3007933
Autor:
Athiwat Hutchaleelaha, Robert M. Scarborough, Penglie Zhang, Susan Edwards, Yanhong Wu, Uma Sinha, Zhaozhong J. Jia, John Woolfrey, Wenrong Huang, Stanley J. Hollennbach, Joseph L. Lambing, Ann E. Arfsten, Yonghong Song, Bing-Yan Zhu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1229-1234
Using N,N-dialkylated benzamidines as the novel P4 motifs, we have designed and synthesized a class of 1-(2-naphthyl)-1H-pyrazole-5-carboxylamides as highly potent and selective fXa inhibitors with significantly improved hydrophilicity and in vitro a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf6e59bdd393461f089032d7d0bc858
https://doi.org/10.1016/j.bmcl.2003.12.054
https://doi.org/10.1016/j.bmcl.2003.12.054
Autor:
John Malinowski, John Woolfrey, Uma Sinha, Katherine Tran, Penglie Zhang, Paul W. Wong, Brian Huang, Gary Park, Jingmei Zuckett, Andrea Reed, Robert M. Scarborough, Stan Hollenbach, Bing-Yan Zhu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1657-1661
Monoamidine FXa inhibitors 3 were designed and synthesized. SAR studies and molecular modeling led to the design of conformationally constrained diaryl ethers 4 and 5, as well as benzopyrrolidinone 7 as potent FXa inhibitors. The monoamidines show hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fbaeed0975d6f76345655f58bb50df
https://doi.org/10.1016/s0960-894x(02)00234-2
https://doi.org/10.1016/s0960-894x(02)00234-2
Autor:
Robert M. Scarborough, Ting Su, John Woolfrey, Gary Park, Yanhong Wu, Zhaozhong J. Jia, Uma Sinha, Bing-Yan Zhu, Paul W. Wong, Brandon Doughan, Brian Huang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2947-2950
A series of potent and selective factor Xa inhibitors was synthesized using various readily available amino acids as central templates. The most potent compound displays IC50 of 3 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d2ade8f4f800dfebf030efeed3ba6a
https://doi.org/10.1016/s0960-894x(01)00585-6
https://doi.org/10.1016/s0960-894x(01)00585-6
Autor:
Matthew Sangyup Lee, Robin Tammie Noguchi, John M. Nuss, Peiwen Zu, Jeff Chen, Brian Kane, Naing Aay, Jia Li, Xian Shi, Brian Hugh Ridgway, Craig Stacy Takeuchi, Elena S. Koltun, Lisa E. Meyr, Henry Johnson, Timothy Patrick Forsyth, Sergey Epshteyn, Brown S David, Byung Gyu Kim, Stefan Engst, Adam A. Galan, Arlyn Arcalas, Gary L. Lewis, Jean-Francois Martini, Vicky Chan, Thomas J. Stout, Robert Kassees, Shwu-Hwa Lin, James W. Leahy, Wentao Zhang, Grace Mann, Philip Tong, Ron Aoyama, Patrick Kearney, Michael Pack, Peiwen Yu, Steven Brian Gendreau, Tai P. Huynh, John Woolfrey, Hongwang Du, Mohamed Abdulkader Ibrahim
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
We report the discovery of a series of 4-aryl-2-aminoalkylpyrimidine derivatives as potent and selective JAK2 inhibitors. High throughput screening of our in-house compound library led to the identification of hit 1, from which optimization resulted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fee7a24cc4076c5e7fbdacc64bdc9f
https://pubmed.ncbi.nlm.nih.gov/23127890
https://pubmed.ncbi.nlm.nih.gov/23127890
Autor:
Hongyan Yan, Vinod V. Panikkath, Tony Chang, John Woolfrey, Jose Cabanillas, Li Liu, Prasad S. Gudem, Kamal Sahota
Publikováno v:
2010 10th IEEE International Conference on Solid-State and Integrated Circuit Technology.
In this paper, the recent advances of CDMA receiver IC design are reviewed. Architecture choices for high linearity low noise CDMA receiver are compared in terms of cost, performance and complexity. The design of tri-band (450M/CELL/PCS) SAW-less CDM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cacc16d7b80624b519ad333bc393c3d7
https://doi.org/10.1109/icsict.2010.5667302
https://doi.org/10.1109/icsict.2010.5667302
Autor:
Lane A. Clizbe, Anjali Pandey, Robert M. Scarborough, Athiwat Hutchaleelaha, Zhaozhong J. Jia, Gary Park, Erick A. Goldman, James Kanter, Lingyan Wang, Yanhong Wu, Ting Su, Gary Probst, Wenhao Li, Susan Edwards, Jingmei Fan, Paul W. Wong, Stanley J. Hollenbach, Uma Sinha, Wenrong Huang, Bauer Shawn M, Joseph L. Lambing, Ann E. Arfsten, Yonghong Song, Penglie Zhang, Bing-Yan Zhu, Bao Liang, John Woolfrey
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(8)
Systematic SAR studies of in vitro factor Xa inhibitory activity around compound 1 were performed by modifying each of the three phenyl rings. A class of highly potent, selective, efficacious and orally bioavailable direct factor Xa inhibitors was di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba738128f7dcbed3dfee77b521674390
https://pubmed.ncbi.nlm.nih.gov/19297154
https://pubmed.ncbi.nlm.nih.gov/19297154
Autor:
Jing Ping Yang, Torsten Trowe, Roel Funke, Peter Lamb, Ryan Fong, David J. Matthews, Sotiria Boukouvala, Timothy S. Heuer, Yong D. Kim, Keith Calkins, Richard E. Cutler, John Woolfrey, Valentina Vysotskaia, Nicole Miller, Steven Brian Gendreau, Mary E. Gerritsen
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(8)
Purpose: Mutations associated with resistance to kinase inhibition are an important mechanism of intrinsic or acquired loss of clinical efficacy for kinase-targeted therapeutics. We report the prospective discovery of ErbB2 mutations that confer resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968484d89e2590d2b3b31c09aa6308b5
https://pubmed.ncbi.nlm.nih.gov/18413839
https://pubmed.ncbi.nlm.nih.gov/18413839
Autor:
Uma Sinha, Penglie Zhang, Erick A. Goldman, John Woolfrey, Yanhong Wu, Ting Su, Jingmei Zuckett, Bauer Shawn M, Lane A. Clizbe, Wenhao Li, Athiwat Hutchaleelaha, Stanley J. Hollenbach, Wenrong Huang, Zhaozhong J. Jia, Robert M. Scarborough, Joseph L. Lambing, Ann E. Arfsten, Yonghong Song, Bing-Yan Zhu
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(9)
A class of N,N-dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines has been discovered as potent factor Xa inhibitors with desirable in vitro and in vivo anticoagulant acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93edd01d3a7a183fca96d5ab759e6ea0
https://pubmed.ncbi.nlm.nih.gov/15080981
https://pubmed.ncbi.nlm.nih.gov/15080981