Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth

Autor: Renate Burger, Andreas Günther, Katja Klausz, Matthias Staudinger, Matthias Peipp, Eva Maria Murga Penas, Stefan Rose-John, John Wijdenes, Martin Gramatzki

Publikováno v: Haematologica, Vol 102, Iss 2 (2017)

Interleukin-6 has an important role in the pathophysiology of multiple myeloma where it supports the growth and survival of the malignant plasma cells in the bone marrow. It belongs to a family of cytokines which use the glycoprotein 130 chain for si

Externí odkaz: https://doaj.org/article/25cfb90bc325498fbf61fd8803006adb

IL-21–Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor–Dependent Manner

Autor: Christophe Ferrand, Olivier Adotevi, Emilie Picard, Olivier Mauvais, Jean-René Pallandre, Yann Godet, Nathalie Chaput, John Wijdenes, Guillaume Kellerman, Virginie Mougey, Jeanne Galaine, Christophe Borg, Pedro Romero, Lise Queiroz, Romain Loyon, Patricia Mercier-Letondal

Publikováno v: The Journal of Immunology. 197:85-96

NK cells are critical for innate immunity–mediated protection. The main roles of NK cells rely on their cytotoxic functions or depend on the tuning of Th1 adaptive immunity by IFN-γ. However, the precise influence of inflammatory cytokines on NK c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9119be64e73c6a1f1eff493719614df
https://doi.org/10.4049/jimmunol.1501147

Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics

Autor: Nico Ongenae, Anna Hultberg, Christian Cambillau, Christophe Blanchetot, Torsten Dreier, Silvia Spinelli, Wieger Hemrika, John Wijdenes, Ava Sadi, Rob C. Roovers, Alex Klarenbeek, Anke Kretz-Rommel, Hans de Haard, Georg Schragel, Aline Desmyter

Publikováno v: Protein Engineering, Design and Selection
Protein Engineering, Design and Selection, Oxford University Press (OUP), 2016, 29 (4), pp.123-133. ⟨10.1093/protein/gzw003⟩
Protein Engineering, Design and Selection, 2016, 29 (4), pp.123-133. ⟨10.1093/protein/gzw003⟩

Highly potent human antibodies are required to therapeutically neutralize cytokines such as interleukin-6 (IL-6) that is involved in many inflammatory diseases and malignancies. Although a number of mutagenesis approaches exist to perform antibody af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49a6a706c7c5b3a85e8c888687bc7cd
https://hal.archives-ouvertes.fr/hal-01439062

CD4-mediated functional activation of human CD4+CD25+ regulatory T cells

Autor: Jürgen Knop, Christian Becker, Jan Kubach, John Wijdenes, Helmut Jonuleit

Publikováno v: European Journal of Immunology. 37:1217-1223

Naturally occurring CD4(+)CD25(+)FoxP3(+) regulatory T cells (CD25(+) Tregs) constitute a specialized population of T cells that is essential for the maintenance of peripheral self-tolerance. The immune regulatory function of CD25(+) Tregs depends up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f42086e9949cd24369f8de39afd298
https://doi.org/10.1002/eji.200636480

Monoclonal antibodies specific for the IL-18 receptor

Autor: Elise Sergent, Brigitte Bonnin, Olivier Frédéric Subiger, Florence Guenot, John Wijdenes, Claudine Vermot-Desroches

Publikováno v: Cellular Immunology. 236:101-104

Interleukin-18, a pleiotropic cytokine is a member of the IL-1 family and has multiple immunoregulatory functions. IL-18 action leads to IFNgamma production by NK or T cells, induces Th1 differentiation and suppresses IgE synthesis by B cells when ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c29a9d1ab25513ac9b1c6d7fc7fb5ac
https://doi.org/10.1016/j.cellimm.2005.08.014